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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 1/2014

01-03-2014 | NON-THEMATIC REVIEW

Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade

Phytoblockers of metastasis cascade

Authors: B. N. Singh, Harikesh Bahadur Singh, A. Singh, Alim H. Naqvi, Braj Raj Singh

Published in: Cancer and Metastasis Reviews | Issue 1/2014

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Abstract

Cancer metastasis is a multistep process in which a cancer cell spreads from the site of the primary lesion, passes through the circulatory system, and establishes a secondary tumor at a new nonadjacent organ or part. Inhibition of cancer progression by dietary phytochemicals (DPs) offers significant promise for reducing the incidence and mortality of cancer. Consumption of DPs in the diet has been linked to a decrease in the rate of metastatic cancer in a number of preclinical animal models and human epidemiological studies. DPs have been reported to modulate the numerous biological events including epigenetic events (noncoding micro-RNAs, histone modification, and DNA methylation) and multiple signaling transduction pathways (Wnt/β-catenin, Notch, Sonic hedgehog, COX-2, EGFR, MAPK-ERK, JAK-STAT, Akt/PI3K/mTOR, NF-κB, AP-1, etc.), which can play a key role in regulation of metastasis cascade. Extensive studies have also been performed to determine the molecular mechanisms underlying antimetastatic activity of DPs, with results indicating that these DPs have significant inhibitory activity at nearly every step of the metastatic cascade. DPs have anticancer effects by inducing apoptosis and by inhibiting cell growth, migration, invasion, and angiogenesis. Growing evidence has also shown that these natural agents potentiate the efficacy of chemotherapy and radiotherapy through the regulation of multiple signaling pathways. In this review, we discuss the variety of molecular mechanisms by which DPs regulate metastatic cascade and highlight the potentials of these DPs as promising therapeutic inhibitors of cancer.
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Metadata
Title
Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade
Phytoblockers of metastasis cascade
Authors
B. N. Singh
Harikesh Bahadur Singh
A. Singh
Alim H. Naqvi
Braj Raj Singh
Publication date
01-03-2014
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1/2014
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-013-9457-1

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