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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 3-4/2012

01-12-2012 | NON-THEMATIC REVIEW

Transcription factor PROX1: its role in development and cancer

Authors: Tamador Elsir, Anja Smits, Mikael S. Lindström, Monica Nistér

Published in: Cancer and Metastasis Reviews | Issue 3-4/2012

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Abstract

The homeobox gene PROX1 is critical for organ development during embryogenesis. The Drosophila homologue, known as prospero has been shown to act as a tumor suppressor by controlling asymmetric cell division of neuroblasts. Likewise, alterations in PROX1 expression and function are associated with a number of human cancers including hematological malignancies, carcinomas of the pancreas, liver and the biliary system, sporadic breast cancer, Kaposiform hemangioendothelioma, colon cancer, and brain tumors. PROX1 is involved in cancer development and progression and has been ascribed both tumor suppressive and oncogenic properties in a variety of different cancer types. However, the exact mechanisms through which PROX1 regulates proliferation, migration, and invasion of cancer cells are by large unknown. This review provides an update on the role of PROX1 in organ development and on its emerging functions in cancer, with special emphasis on the central nervous system and glial brain tumors.
Literature
1.
Abate-Shen, C. (2002). Deregulated homeobox gene expression in cancer: cause or consequence? Nature Reviews. Cancer, 2(10), 777–785.PubMedCrossRef
2.
Oliver, G., Sosa-Pineda, B., Geisendorf, S., Spana, E. P., Doe, C. Q., & Gruss, P. (1993). Prox1, a prospero-related homeobox gene expressed during mouse development. Mechanisms of Development, 44(1), 3–16.PubMedCrossRef
3.
Zinovieva, R. D., Duncan, M. K., Johnson, T. R., Torres, R., Polymeropoulos, M. H., & Tomarev, S. I. (1996). Structure and chromosomal localization of the human homeobox gene Prox1. Genomics, 35(3), 517–522.PubMedCrossRef
4.
Banerjee-Basu, S., Landsman, D., & Baxevanis, A. D. (1999). Threading analysis of prospero-type homeodomains. In Silico Biology, 1(3), 163–173.PubMed
5.
Ryter, J. M., Doe, C. Q., & Matthews, B. W. (2002). Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain. Structure, 10(11), 1541–1549.PubMedCrossRef
6.
Yousef, M. S., & Matthews, B. W. (2005). Structural basis of prospero-DNA interaction: implications for transcription regulation in developing cells. Structure, 13(4), 601–607.PubMedCrossRef
7.
Song, K. H., Li, T., & Chiang, J. Y. (2006). A prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. Journal of Biological Chemistry, 281(15), 10081–10088.PubMedCrossRef
8.
Steffensen, K. R., Holter, E., Bavner, A., Nilsson, M., Pelto-Huikko, M., Tomarev, S., et al. (2004). Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Reports, 5(6), 613–619.PubMedCrossRef
9.
Chen, X., Patel, T. P., Simirskii, V. I., & Duncan, M. K. (2008). PCNA interacts with Prox1 and represses its transcriptional activity. Molecular Vision, 14, 2076–2086.PubMed
10.
Pan, M. R., Chang, T. M., Chang, H. C., Su, J. L., Wang, H. W., & Hung, W. C. (2009). Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells. Journal of Cell Science, 122(Pt 18), 3358–3364.PubMedCrossRef
11.
Shan, S. F., Wang, L. F., Zhai, J. W., Qin, Y., Ouyang, H. F., Kong, Y. Y., et al. (2008). Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification. FEBS Letters, 582(27), 3723–3728.PubMedCrossRef
12.
Doe, C. Q., Chu-LaGraff, Q., Wright, D. M., & Scott, M. P. (1991). The prospero gene specifies cell fates in the Drosophila central nervous system. Cell, 65(3), 451–464.PubMedCrossRef
13.
Betschinger, J., & Knoblich, J. A. (2004). Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Current Biology, 14(16), R674–R685.PubMedCrossRef
14.
15.
Myster, D. L., & Duronio, R. J. (2000). To differentiate or not to differentiate? Current Biology, 10(8), R302–R304.PubMedCrossRef
16.
Betschinger, J., Mechtler, K., & Knoblich, J. A. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell, 124(6), 1241–1253.PubMedCrossRef
17.
18.
Choksi, S. P., Southall, T. D., Bossing, T., Edoff, K., de Wit, E., Fischer, B. E., et al. (2006). Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Developmental Cell, 11(6), 775–789.PubMedCrossRef
19.
Hirata, J., Nakagoshi, H., Nabeshima, Y., & Matsuzaki, F. (1995). Asymmetric segregation of the homeodomain protein prospero during Drosophila development. Nature, 377(6550), 627–630.PubMedCrossRef
20.
Southall, T. D., & Brand, A. H. (2009). Neural stem cell transcriptional networks highlight genes essential for nervous system development. EMBO Journal, 28(24), 3799–3807.PubMedCrossRef
21.
Griffiths, R. L., & Hidalgo, A. (2004). Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO Journal, 23(12), 2440–2450.PubMedCrossRef
22.
Raff, M. C., Durand, B., & Gao, F. B. (1998). Cell number control and timing in animal development: the oligodendrocyte cell lineage. International Journal of Developmental Biology, 42(3), 263–267.PubMed
23.
Stacey, S. M., Thomas, G. B., Labbe, A., & Van Meyel, D. J. (2007). Longitudinal glia in the fly CNS: pushing the envelope on glial diversity and neuron-glial interactions. Neuron Glia Biology, 3(1), 27–33.PubMedCrossRef
24.
Hidalgo, A., & Griffiths, R. (2004). Coupling glial numbers and axonal patterns. Cell Cycle, 3(9), 1118–1120.PubMedCrossRef
25.
Freeman, M. R., Delrow, J., Kim, J., Johnson, E., & Doe, C. Q. (2003). Unwrapping glial biology: gcm target genes regulating glial development, diversification, and function. Neuron, 38(4), 567–580.PubMedCrossRef
26.
Freeman, M. R., & Doe, C. Q. (2001). Asymmetric prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development, 128(20), 4103–4112.PubMed
27.
Hong, Y. K., & Detmar, M. (2003). Prox1, master regulator of the lymphatic vasculature phenotype. Cell and Tissue Research, 314(1), 85–92.PubMedCrossRef
28.
Weller, M., & Tautz, D. (2003). Prospero and Snail expression during spider neurogenesis. Development Genes and Evolution, 213(11), 554–566.PubMedCrossRef
29.
Wigle, J. T., Chowdhury, K., Gruss, P., & Oliver, G. (1999). Prox1 function is crucial for mouse lens-fibre elongation. Nature Genetics, 21(3), 318–322.PubMedCrossRef
30.
Wigle, J. T., & Oliver, G. (1999). Prox1 function is required for the development of the murine lymphatic system. Cell, 98(6), 769–778.PubMedCrossRef
31.
Galeeva, A., Treuter, E., Tomarev, S., & Pelto-Huikko, M. (2007). A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Neuroscience, 146(2), 604–616.PubMedCrossRef
32.
Lavado, A., & Oliver, G. (2007). Prox1 expression patterns in the developing and adult murine brain. Developmental Dynamics, 236(2), 518–524.PubMedCrossRef
33.
Kaltezioti, V., Kouroupi, G., Oikonomaki, M., Mantouvalou, E., Stergiopoulos, A., Charonis, A., et al. (2010). Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biology, 8(12), e1000565.PubMedCrossRef
34.
Karalay, O., Doberauer, K., Vadodaria, K. C., Knobloch, M., Berti, L., Miquelajauregui, A., et al. (2011). Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences of the United States of America, 108(14), 5807–5812.PubMedCrossRef
35.
Misra, K., Gui, H., & Matise, M. P. (2008). Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord. Developmental Dynamics, 237(2), 393–402.PubMedCrossRef
36.
Torii, M., Matsuzaki, F., Osumi, N., Kaibuchi, K., Nakamura, S., Casarosa, S., et al. (1999). Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development, 126(3), 443–456.PubMed
37.
Elkouris, M., Balaskas, N., Poulou, M., Politis, P. K., Panayiotou, E., Malas, S., et al. (2011). Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis. Stem Cells. doi:10.​1002/​stem.​554.
38.
Deng, W., Aimone, J. B., & Gage, F. H. (2010). New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nature Reviews Neuroscience, 11(5), 339–350.PubMedCrossRef
39.
Lavado, A., Lagutin, O. V., Chow, L. M., Baker, S. J., & Oliver, G. (2010). Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biology. doi:10.​1371/​1000460.
40.
Duncan, M. K., Cui, W., Oh, D. J., & Tomarev, S. I. (2002). Prox1 is differentially localized during lens development. Mechanisms of Development, 112(1–2), 195–198.PubMedCrossRef
41.
Tomarev, S. I., Sundin, O., Banerjee-Basu, S., Duncan, M. K., Yang, J. M., & Piatigorsky, J. (1996). Chicken homeobox gene Prox 1 related to Drosophila prospero is expressed in the developing lens and retina. Developmental Dynamics, 206(4), 354–367.PubMedCrossRef
42.
Dyer, M. A., Livesey, F. J., Cepko, C. L., & Oliver, G. (2003). Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nature Genetics, 34(1), 53–58.PubMedCrossRef
43.
Burke, Z., & Oliver, G. (2002). Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mechanisms of Development, 118(1–2), 147–155.PubMedCrossRef
44.
Sosa-Pineda, B., Wigle, J. T., & Oliver, G. (2000). Hepatocyte migration during liver development requires Prox1. Nature Genetics, 25(3), 254–255.PubMedCrossRef
45.
Dufour, C. R., Levasseur, M. P., Pham, N. H., Eichner, L. J., Wilson, B. J., Charest-Marcotte, A., et al. (2011). Genomic convergence among ERRalpha, PROX1, and BMAL1 in the control of metabolic clock outputs. PLoS Genetics, 7(6), e1002143.PubMedCrossRef
46.
Charest-Marcotte, A., Dufour, C. R., Wilson, B. J., Tremblay, A. M., Eichner, L. J., Arlow, D. H., et al. (2010). The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions. Genes & Development, 24(6), 537–542.CrossRef
47.
Wang, J., Kilic, G., Aydin, M., Burke, Z., Oliver, G., & Sosa-Pineda, B. (2005). Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells. Developmental Biology, 286(1), 182–194.PubMedCrossRef
48.
Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I., Grosveld, G., Gunn, M. D., et al. (2002). An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO Journal, 21(7), 1505–1513.PubMedCrossRef
49.
Tammela, T., & Alitalo, K. (2010). Lymphangiogenesis: molecular mechanisms and future promise. Cell, 140(4), 460–476.PubMedCrossRef
50.
Johnson, N. C., Dillard, M. E., Baluk, P., McDonald, D. M., Harvey, N. L., Frase, S. L., et al. (2008). Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes & Development, 22(23), 3282–3291.CrossRef
51.
Makinen, T., Norrmen, C., & Petrova, T. V. (2007). Molecular mechanisms of lymphatic vascular development. Cellular and Molecular Life Sciences, 64(15), 1915–1929.PubMedCrossRef
52.
Petrova, T. V., Makinen, T., Makela, T. P., Saarela, J., Virtanen, I., Ferrell, R. E., et al. (2002). Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO Journal, 21(17), 4593–4599.PubMedCrossRef
53.
Rodriguez-Niedenfuhr, M., Papoutsi, M., Christ, B., Nicolaides, K. H., von Kaisenberg, C. S., Tomarev, S. I., et al. (2001). Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts. Anat Embryol (Berl), 204(5), 399–406.CrossRef
54.
Risebro, C. A., Searles, R. G., Melville, A. A., Ehler, E., Jina, N., Shah, S., et al. (2009). Prox1 maintains muscle structure and growth in the developing heart. Development, 136(3), 495–505.PubMedCrossRef
55.
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., et al. (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathologica, 114(2), 97–109.PubMedCrossRef
56.
Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., et al. (2007). Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & Development, 21(21), 2683–2710.CrossRef
57.
Elsir, T., Eriksson, A., Orrego, A., Lindstrom, M. S., & Nister, M. (2010). Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas. Journal of Neuropathology and Experimental Neurology, 69(2), 129–138.PubMedCrossRef
58.
Elsir, T., Qu, M., Berntsson, S. G., Orrego, A., Olofsson, T., Lindstrom, M. S., et al. (2011). PROX1 is a predictor of survival for gliomas WHO grade II. British Journal of Cancer, 104(11), 1747–1754.PubMedCrossRef
59.
Holmberg, J., He, X., Peredo, I., Orrego, A., Hesselager, G., Ericsson, C., et al. (2011). Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PLoS One. doi:10.​1371/​journal.​pone.​0018454.
60.
Grau, S. J., Trillsch, F., von Luttichau, I., Nelson, P. J., Herms, J., Tonn, J. C., et al. (2008). Lymphatic phenotype of tumour vessels in malignant gliomas. Neuropathology and Applied Neurobiology, 34(6), 675–679.PubMedCrossRef
61.
Jenny, B., Harrison, J. A., Baetens, D., Tille, J. C., Burkhardt, K., Mottaz, H., et al. (2006). Expression and localization of VEGF-C and VEGFR-3 in glioblastomas and haemangioblastomas. The Journal of Pathology, 209(1), 34–43.PubMedCrossRef
62.
Mueller, S., & Matthay, K. K. (2009). Neuroblastoma: biology and staging. Current Oncology Reports, 11(6), 431–438.PubMedCrossRef
63.
Becker, J., Wang, B., Pavlakovic, H., Buttler, K., & Wilting, J. (2010). Homeobox transcription factor Prox1 in sympathetic ganglia of vertebrate embryos: correlation with human stage 4 s neuroblastoma. Pediatric Research, 68(2), 112–117.PubMedCrossRef
64.
Kinzler, K. W., & Vogelstein, B. (1996). Lessons from hereditary colorectal cancer. Cell, 87(2), 159–170.PubMedCrossRef
65.
Petrova, T. V., Nykanen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., et al. (2008). Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell, 13(5), 407–419.PubMedCrossRef
66.
Edvardsson, K., Strom, A., Jonsson, P., Gustafsson, J. A., & Williams, C. (2011). Estrogen receptor beta induces antiinflammatory and antitumorigenic networks in colon cancer cells. Molecular Endocrinology, 25(6), 969–979.PubMedCrossRef
67.
Skog, M., Bono, P., Lundin, M., Lundin, J., Louhimo, J., Linder, N., et al. (2011). Expression and prognostic value of transcription factor PROX1 in colorectal cancer. British Journal of Cancer, 2011(4), 297.
68.
Shimoda, M., Takahashi, M., Yoshimoto, T., Kono, T., Ikai, I., & Kubo, H. (2006). A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clinical Cancer Research, 12(20 Pt 1), 6005–6011.PubMedCrossRef
69.
Akagami, M., Kawada, K., Kubo, H., Kawada, M., Takahashi, M., Kaganoi, J., et al. (2011). Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-gamma in esophageal cancer cells. Annals of Surgical Oncology, 18(13), 3868–3877.PubMedCrossRef
70.
Kaganoi, J., Watanabe, G., Okabe, M., Nagatani, S., Kawabe, A., Shimada, Y., et al. (2007). STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo. Annals of Surgical Oncology, 14(4), 1405–1415.PubMedCrossRef
71.
Schneider, M., Buchler, P., Giese, N., Giese, T., Wilting, J., Buchler, M. W., et al. (2006). Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. International Journal of Oncology, 28(4), 883–890.PubMed
72.
Laerm, A., Helmbold, P., Goldberg, M., Dammann, R., Holzhausen, H. J., & Ballhausen, W. G. (2007). Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. Journal of Hepatology, 46(1), 89–97.PubMedCrossRef
73.
Nagai, H., Li, Y., Hatano, S., Toshihito, O., Yuge, M., Ito, E., et al. (2003). Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. Genes, Chromosomes & Cancer, 38(1), 13–21.CrossRef
74.
Versmold, B., Felsberg, J., Mikeska, T., Ehrentraut, D., Kohler, J., Hampl, J. A., et al. (2007). Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. International Journal of Cancer, 121(3), 547–554.CrossRef
75.
Uldrick, T. S., & Whitby, D. (2011). Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma. Cancer Letters, 305(2), 150–162.PubMedCrossRef
76.
Jussila, L., Valtola, R., Partanen, T. A., Salven, P., Heikkila, P., Matikainen, M. T., et al. (1998). Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. Cancer Research, 58(8), 1599–1604.PubMed
77.
Hong, Y. K., Foreman, K., Shin, J. W., Hirakawa, S., Curry, C. L., Sage, D. R., et al. (2004). Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics, 36(7), 683–685.PubMedCrossRef
78.
Yoo, J., Kang, J., Lee, H. N., Aguilar, B., Kafka, D., Lee, S., et al. (2010). Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathogens, 6(8), e1001046.PubMedCrossRef
79.
Elyada, E., Pribluda, A., Goldstein, R. E., Morgenstern, Y., Brachya, G., Cojocaru, G., et al. (2011). CKIalpha ablation highlights a critical role for p53 in invasiveness control. Nature, 470(7334), 409–413.PubMedCrossRef
80.
Dadras, S. S., Skrzypek, A., Nguyen, L., Shin, J. W., Schulz, M. M., Arbiser, J., et al. (2008). Prox-1 promotes invasion of kaposiform hemangioendotheliomas. The Journal of Investigative Dermatology, 128(12), 2798–2806.PubMedCrossRef
81.
Cao, Y. (2005). Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nature Reviews. Cancer, 5(9), 735–743.PubMedCrossRef
82.
83.
Hope, K. J., Cellot, S., Ting, S. B., MacRae, T., Mayotte, N., Iscove, N. N., et al. (2010). An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell, 7(1), 101–113.PubMedCrossRef
84.
Monzani, E., Facchetti, F., Galmozzi, E., Corsini, E., Benetti, A., Cavazzin, C., et al. (2007). Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. European Journal of Cancer, 43(5), 935–946.PubMedCrossRef
85.
Balla, M. M., Vemuganti, G. K., Kannabiran, C., Honavar, S. G., & Murthy, R. (2009). Phenotypic characterization of retinoblastoma for the presence of putative cancer stem-like cell markers by flow cytometry. Investigative Ophthalmology & Visual Science, 50(4), 1506–1514.CrossRef
86.
Steiner, B., Zurborg, S., Horster, H., Fabel, K., & Kempermann, G. (2008). Differential 24 h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures. Neuroscience, 154(2), 521–529.PubMedCrossRef
87.
Zheng, H., Ying, H., Yan, H., Kimmelman, A. C., Hiller, D. J., Chen, A. J., et al. (2008). Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harbor Symposia on Quantitative Biology, 73, 427–437.PubMedCrossRef
88.
Srinivasan, R. S., Geng, X., Yang, Y., Wang, Y., Mukatira, S., Studer, M., et al. (2010). The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes & Development, 24(7), 696–707.CrossRef
89.
Yoshimatsu, Y., Yamazaki, T., Mihira, H., Itoh, T., Suehiro, J., Yuki, K., et al. (2011). Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. Journal of Cell Science, 124(Pt 16), 2753–2762.PubMedCrossRef
90.
Azuma, K., Urano, T., Watabe, T., Ouchi, Y., & Inoue, S. (2011). PROX1 suppresses vitamin K-induced transcriptional activity of steroid and xenobiotic receptor. Genes to Cells, 16(11), 1063–1070.PubMedCrossRef
91.
Takahashi, M., Yoshimoto, T., Shimoda, M., Kono, T., Koizumi, M., Yazumi, S., et al. (2006). Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells. Neoplasia, 8(12), 1003–1010.PubMedCrossRef
92.
Dudas, J., Mansuroglu, T., Moriconi, F., Haller, F., Wilting, J., Lorf, T., et al. (2008). Altered regulation of Prox1-gene-expression in liver tumors. BMC Cancer, 8(92), 92.PubMedCrossRef
93.
Yoshimoto, T., Takahashi, M., Nagayama, S., Watanabe, G., Shimada, Y., Sakasi, Y., et al. (2007). RNA mutations of prox1 detected in human esophageal cancer cells by the shifted termination assay. Biochemical and Biophysical Research Communications, 359(2), 258–262.PubMedCrossRef
Metadata
Title
Transcription factor PROX1: its role in development and cancer
Authors
Tamador Elsir
Anja Smits
Mikael S. Lindström
Monica Nistér
Publication date
01-12-2012
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 3-4/2012
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-012-9390-8

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