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The International Journal of Cardiovascular Imaging

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Open Access 01-03-2016 | Original Paper

Increased native T1-values at the interventricular insertion regions in precapillary pulmonary hypertension

Authors: Onno A. Spruijt, Loek Vissers, Harm-Jan Bogaard, Mark B. M. Hofman, Anton Vonk-Noordegraaf, J. Tim Marcus

Published in: The International Journal of Cardiovascular Imaging | Issue 3/2016

Abstract

Cardiac magnetic resonance imaging of the pressure overloaded right ventricle (RV) of precapillary pulmonary hypertension (PH) patients, exhibits late gadolinium enhancement at the interventricular insertion regions, a phenomenon which has been linked to focal fibrosis. Native T1-mapping is an alternative technique to characterize myocardium and has the advantage of not requiring the use of contrast agents. The aim of this study was to characterize the myocardium of idiopathic pulmonary arterial hypertension (IPAH), systemic scleroderma related PH (PAH-Ssc) and chronic thromboembolic PH (CTEPH) patients using native T1-mapping and to see whether native T1-values were related to disease severity. Furthermore, we compared native T1-values between the different precapillary PH categories. Native T1-mapping was performed in 46 IPAH, 14 PAH-SSc and 10 CTEPH patients and 10 control subjects. Native T1-values were assessed using regions of interest at the RV and LV free wall, interventricular septum and interventricular insertion regions. In PH patients, native T1-values of the interventricular insertion regions were significantly higher than the native T1-values of the RV free wall, LV free wall and interventricular septum. Native T1-values at the insertion regions were significantly related to disease severity. Native T1-values were not different between IPAH, PAH-Ssc and CTEPH patients. Native T1-values of the interventricular insertion regions are significantly increased in precapillary PH and are related to disease severity. Native T1-mapping can be developed as an alternative technique for the characterization of the interventricular insertion regions and has the advantage of not requiring the use of contrast agents.

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Title: Increased native T1-values at the interventricular insertion regions in precapillary pulmonary hypertension
Authors: Onno A. Spruijt
Loek Vissers
Harm-Jan Bogaard
Mark B. M. Hofman
Anton Vonk-Noordegraaf
J. Tim Marcus
Publication date: 01-03-2016
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 3/2016
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-015-0787-7

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