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Cancer Causes & Control
Published in: Cancer Causes & Control 5/2011

01-05-2011 | Original paper

Oropharyngeal cancer incidence trends: diminishing racial disparities

Authors: Linda Morris Brown, David P. Check, Susan S. Devesa

Published in: Cancer Causes & Control | Issue 5/2011

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Abstract

Objective

The aim of this article is to evaluate oral cavity/pharyngeal cancer (OCPC) trends that may reflect changes in cigarette smoking, alcohol consumption, and human papillomavirus (HPV) infection.

Methods

We used Surveillance, Epidemiology, and End Results program data for 58,204 cases diagnosed during 1977–2007 to classify if squamous cell carcinomas of the OCP by anatomic site are potentially HPV-related.

Results

OCPC rates among men peaked during 1982–1986 before declining, most rapidly (46%) among blacks. Rates decreased least rapidly among white males while declining at intermediate paces among other ethnic groups (Asian/Pacific Islanders and Hispanics) and females. Among the men during the recent 16-year time period, the annual percent change for HPV-unrelated sites was much steeper [−6.0% (95% CI = −7.2 to −4.9)] among blacks than whites [−2.5% (95% CI = −2.9 to −2.1)]; for HPV-related sites, it was −1.7% (95% CI = −2.6 to −0.7) among blacks, in striking contrast to +3.3% (95% CI = 2.5–4.0) among whites. HPV-related rates rose rapidly among the white men born since the mid-1940s, tripling among those aged 25–44 and recently surpassing the black male rate. Relative survival rates rose over the study period due to improvements among HPV-related cases.

Conclusions

The OCPC decreases found among all the race/sex groups reflect reductions in smoking prevalence and alcohol consumption. Rising HPV-related cancers among white men may reflect changes in sexual practices since the mid-1960s.
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Metadata
Title
Oropharyngeal cancer incidence trends: diminishing racial disparities
Authors
Linda Morris Brown
David P. Check
Susan S. Devesa
Publication date
01-05-2011
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 5/2011
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-011-9748-1

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