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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2010

Open Access 01-12-2010 | Research

Low prevalence of Human Papillomavirus in oral cavity carcinomas

Authors: Jerry Machado, Patricia P Reis, Tong Zhang, Colleen Simpson, Wei Xu, Bayardo Perez-Ordonez, David P Goldstein, Dale H Brown, Ralph W Gilbert, Patrick J Gullane, Jonathan C Irish, Suzanne Kamel-Reid

Published in: Head & Neck Oncology | Issue 1/2010

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Abstract

Background

Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported.

Methods

We assessed HPV involvement in HNSCC using the Roche Linear Array HPV Genotyping Test, which can detect 37 different HPV types. We examined the prevalence of HPV infection in 92 HNSCCs (oropharynx, oral cavity, and other HNSCC sites).

Results

HPV was frequently detected in oropharyngeal cancers (OPCs) (16/22, 73%), but was uncommon in oral cavity cancers (2/53, 4%), and in other HNSCC subsites (1/17, 6%). HPV positive tumors were associated with patients that were 40-60 years old (p = 0.02), and node positive (p = < 0.0001). HPV 16 was the most prevalent type, but other types detected included 6, 18, 33, 35, 45, and 52/58.

Conclusion

Our results show that in contrast to oropharyngeal cancers, oral cancers and other HNSCCs infrequently harbor HPV.
Appendix
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Metadata
Title
Low prevalence of Human Papillomavirus in oral cavity carcinomas
Authors
Jerry Machado
Patricia P Reis
Tong Zhang
Colleen Simpson
Wei Xu
Bayardo Perez-Ordonez
David P Goldstein
Dale H Brown
Ralph W Gilbert
Patrick J Gullane
Jonathan C Irish
Suzanne Kamel-Reid
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2010
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-2-6

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