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01-10-2019 | Breast Cancer | Preclinical study

Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer

Authors: Jasmin Zeindler, Fiorenzo Angehrn, Raoul Droeser, Silvio Däster, Salvatore Piscuoglio, Charlotte K. Y. Ng, Ergin Kilic, Robert Mechera, Samuel Meili, Andrej Isaak, Walter P. Weber, Simone Muenst, Savas Deniz Soysal

Published in: Breast Cancer Research and Treatment | Issue 3/2019

Abstract

Purpose

Myeloperoxidase (MPO) is an enzyme secreted by neutrophil granulocytes as a result of phagocytosis during inflammation. In colorectal cancer, tumour infiltration by MPO expressing cells has been shown to be independently associated with a favourable prognosis. In this study, we explored the role of MPO-positive cell infiltration and its prognostic significance in invasive breast cancer.

Methods

We performed immunohistochemical staining for MPO on multiple tissue microarrays comprising a total of 928 human breast cancer samples with detailed clinical-pathological annotation and outcome data.

Results

MPO-positive cell infiltration (≥ 5 cells/tissue punch) was found in 150 (16%) of the 928 evaluable breast cancer cases. In univariate survival analyses, infiltration by MPO-positive cells was associated with a significantly better overall survival (p < 0.001). In subset univariate analyses, the infiltration by MPO-positive cells was associated with significantly better overall survival in the Luminal B/HER2-negative subtype (p = 0.005), the HER2 enriched subtype (p = 0.011), and the Triple Negative subtype (p < 0.001). In multivariate analysis, MPO expression proved to be an independent prognostic factor for improved overall survival (p < 0.001).

Conclusions

This is the first study to show that infiltration of MPO-positive cells is an independent prognostic biomarker for improved overall survival in human breast cancer.

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Title: Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer
Authors: Jasmin Zeindler
Fiorenzo Angehrn
Raoul Droeser
Silvio Däster
Salvatore Piscuoglio
Charlotte K. Y. Ng
Ergin Kilic
Robert Mechera
Samuel Meili
Andrej Isaak
Walter P. Weber
Simone Muenst
Savas Deniz Soysal
Publication date: 01-10-2019
Publisher: Springer US
Keywords: Breast Cancer
Breast Cancer
Published in: Breast Cancer Research and Treatment / Issue 3/2019
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-019-05336-3

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