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01-04-2012 | Preclinical Study

Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes

Authors: Jord H. A. Nagel, Justine K. Peeters, Marcel Smid, Anieta M. Sieuwerts, Marijke Wasielewski, Vanja de Weerd, Anita M. A. C. Trapman-Jansen, Ans van den Ouweland, Hennie Brüggenwirth, Wilfred F. J. van IJcken, Jan G. M. Klijn, Peter J. van der Spek, John A. Foekens, John W. M. Martens, Mieke Schutte, Hanne Meijers-Heijboer

Published in: Breast Cancer Research and Treatment | Issue 2/2012

Abstract

CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with previous work, all CHEK2 1100delC mutant tumors clustered among the hormone receptor-positive breast cancers. In the hormone receptor-positive subset, a 40-gene CHEK2 signature was subsequently defined that significantly associated with CHEK2 1100delC breast cancers. The identification of a CHEK2 gene signature implies an unexpected biological homogeneity among the CHEK2 1100delC breast cancers. In addition, all 26 CHEK2 1100delC tumors classified as luminal intrinsic subtype breast cancers, with 8 luminal A and 18 luminal B tumors. This biological make-up of CHEK2 1100delC breast cancers suggests that a relatively limited number of additional susceptibility alleles are involved in the polygenic CHEK2 model. Identification of these as-yet-unknown susceptibility alleles should be aided by clues from the 40-gene CHEK2 signature.

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Title: Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes
Authors: Jord H. A. Nagel
Justine K. Peeters
Marcel Smid
Anieta M. Sieuwerts
Marijke Wasielewski
Vanja de Weerd
Anita M. A. C. Trapman-Jansen
Ans van den Ouweland
Hennie Brüggenwirth
Wilfred F. J. van IJcken
Jan G. M. Klijn
Peter J. van der Spek
John A. Foekens
John W. M. Martens
Mieke Schutte
Hanne Meijers-Heijboer
Publication date: 01-04-2012
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 2/2012
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-011-1588-x

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