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01-07-2009 | Review

The hedgehog pathway as a therapeutic target for treatment of breast cancer

Authors: M. F. Barginear, M. Leung, D. R. Budman

Published in: Breast Cancer Research and Treatment | Issue 2/2009

Abstract

The Hedgehog (Hh) signaling pathway plays a key role in a variety of processes, such as embryogenesis and maintenance of adult tissue homeostasis. It is also becoming increasingly clear that this pathway can have a crucial role in tumorigenesis. Most recently, the Hh signaling pathway has been implicated in the development and maintenance of breast cancer. Here we review Hh signaling, advances in small molecule and antibody-based inhibitors targeting the Hh pathway, and dysregulation of the Hh signaling pathway in breast cancer.

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Title: The hedgehog pathway as a therapeutic target for treatment of breast cancer
Authors: M. F. Barginear
M. Leung
D. R. Budman
Publication date: 01-07-2009
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 2/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-009-0423-0

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