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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-09-2007

Hedgehog Signaling in Mammary Gland Development and Breast Cancer

Authors: Sarah Hatsell, Andra R. Frost

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2-3/2007

Abstract

The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary gland. Activation of Hedgehog signaling either by mutation or misexpression of pathway members can lead to the development and/or progression of cancers in multiple organs. This review addresses the current understanding and controversies of Hedgehog signaling in mammary gland development and its potential role in promoting breast carcinogenesis and cancer progression.

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Title: Hedgehog Signaling in Mammary Gland Development and Breast Cancer
Authors: Sarah Hatsell
Andra R. Frost
Publication date: 01-09-2007
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2-3/2007
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-007-9048-2

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