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AIDS and Behavior
Published in: AIDS and Behavior 7/2020

01-07-2020 | Human Immunodeficiency Virus | Original Paper

Adherence to Antiretroviral Therapy Among HIV Patients in India: A Systematic Review and Meta-analysis

Authors: Apurba Chakraborty, Ronald C. Hershow, Dima M. Qato, Leslie Stayner, Mark S. Dworkin

Published in: AIDS and Behavior | Issue 7/2020

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Abstract

We conducted a systematic review and meta-analysis to estimate the prevalence of adherence to antiretroviral therapy (ART) in India, the third largest HIV epidemic in the world. We identified peer reviewed literature published between 2007 and 2017 to extract data on ART adherence. We estimated pooled prevalence of adherence to ART using a random-effects model. Thirty-two eligible studies (n = 11,543) were included in the meta-analysis. Studies were mostly clustered in the southern and western Indian states. Overall, 77% (95% Confidence Interval 73–82; I2 = 96.80%) of patients had optimum adherence to ART. Women had higher prevalence of optimum adherence compared to men. Depression or anxiety were significant risk factors in seven of the fifteen studies reporting determinants of nonadherence. Studies should be performed to explore the reasons for gender gap in ART adherence and HIV program in India should prioritize mental health issues among HIV patients to improve ART adherence.
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Metadata
Title
Adherence to Antiretroviral Therapy Among HIV Patients in India: A Systematic Review and Meta-analysis
Authors
Apurba Chakraborty
Ronald C. Hershow
Dima M. Qato
Leslie Stayner
Mark S. Dworkin
Publication date
01-07-2020
Publisher
Springer US
Published in
AIDS and Behavior / Issue 7/2020
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-020-02779-4

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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