Published in:
01-10-2011 | Original Paper
Once Daily Dosing Improves Adherence to Antiretroviral Therapy
Authors:
Janet Raboud, Maggie Li, Sharon Walmsley, Curtis Cooper, Sandra Blitz, Ahmed M. Bayoumi, Sean Rourke, Sergio Rueda, Anita Rachlis, Nicole Mittmann, Marek Smieja, Evan Collins, Mona R. Loutfy
Published in:
AIDS and Behavior
|
Issue 7/2011
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Abstract
We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42–54), median years of ART 9 (IQR 5–13) and median CD4 count 463 cells/mm3 (IQR 320–638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.