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Modern Rheumatology
Published in: Modern Rheumatology 2/2008

01-04-2008 | Case Report

Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis

Authors: Yusuke Miwa, Takeo Isozaki, Kuninobu Wakabayashi, Tsuyoshi Odai, Mizuho Matsunawa, Nobuyuki Yajima, Masao Negishi, Hirotsugu Ide, Tsuyoshi Kasama, Mitsuru Adachi, Tomoyuki Hisayuki, Tamiko Takemura

Published in: Modern Rheumatology | Issue 2/2008

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Abstract

A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment was started. She presented with dyspnea. Chest X-ray and computed tomography (CT) showed ground-glass opacity and IP. Although tacrolimus was stopped, she died of respiratory failure. At autopsy, both the upper and lower lung fields showed usual IP and the organizing stage of diffuse alveolar damage. The former is common, but the latter is uncommon, suggesting tacrolimus may cause severe alveolar damage.
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Metadata
Title
Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis
Authors
Yusuke Miwa
Takeo Isozaki
Kuninobu Wakabayashi
Tsuyoshi Odai
Mizuho Matsunawa
Nobuyuki Yajima
Masao Negishi
Hirotsugu Ide
Tsuyoshi Kasama
Mitsuru Adachi
Tomoyuki Hisayuki
Tamiko Takemura
Publication date
01-04-2008
Publisher
Springer Japan
Published in
Modern Rheumatology / Issue 2/2008
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-008-0034-3

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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