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Journal of Bone and Mineral Metabolism
Published in: Journal of Bone and Mineral Metabolism 3/2023

30-08-2022 | osteosarcoma | Invited Review

Wnt signaling: a double-edged sword in protecting bone from cancer

Authors: Xun Sun, Kexin Li, Bai-Yan Li, Hiroki Yokota

Published in: Journal of Bone and Mineral Metabolism | Issue 3/2023

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Abstract

Wnt signaling plays a critical role in loading-driven bone formation and bone homeostasis, whereas its activation in cancer cells promotes their progression. Currently, major research efforts in cancer treatment have been directed to the development of Wnt inhibitors. Recent studies on tumor–bone interactions, however, presented multiple lines of evidence that support a tumor-suppressive role of Lrp5, a Wnt co-receptor, and β-catenin, in Wnt signaling. This review describes the action of Wnt signaling as a double-edged sword in the bone microenvironment and suggests the possibility of a novel option for protecting bone from cancer.
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Metadata
Title
Wnt signaling: a double-edged sword in protecting bone from cancer
Authors
Xun Sun
Kexin Li
Bai-Yan Li
Hiroki Yokota
Publication date
30-08-2022
Publisher
Springer Nature Singapore
Published in
Journal of Bone and Mineral Metabolism / Issue 3/2023
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-022-01363-1

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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