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Archives of Virology
Published in: Archives of Virology 2/2013

01-02-2013 | Original Article

Characterization of low-pathogenic H6N6 avian influenza viruses in central China

Authors: Yanfeng Yao, Huadong Wang, Quanjiao Chen, Hongbo Zhang, Tao Zhang, Jianjun Chen, Bing Xu, Hanzhong Wang, Bing Sun, Ze Chen

Published in: Archives of Virology | Issue 2/2013

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Abstract

Three strains of H6N6 subtype avian influenza virus (AIV) were isolated from live-poultry markets of central China during 2009-2010. A phylogenetic analysis showed that these isolates originated from gene reassortment among different virus lineages of the H6 subtype. In an experimental infection of animals, the selected isolate was non-pathogenic for chickens and low-pathogenic for mice. The wild-type isolate was capable of replication in mouse lung without prior adaptation, and the virulence to mice increased rapidly during adaption in mouse lung. The genomes of viruses of passage 0 (P0), P4, and P8 were sequenced and compared, and virulence-related amino acid substitutions were found in multiple sites during mouse lung passage.
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Metadata
Title
Characterization of low-pathogenic H6N6 avian influenza viruses in central China
Authors
Yanfeng Yao
Huadong Wang
Quanjiao Chen
Hongbo Zhang
Tao Zhang
Jianjun Chen
Bing Xu
Hanzhong Wang
Bing Sun
Ze Chen
Publication date
01-02-2013
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 2/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1496-3

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