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Archives of Virology
Published in: Archives of Virology 2/2013

01-02-2013 | Brief Report

H5N1 highly pathogenic avian influenza virus isolated from conjunctiva of a whooper swan with neurological signs

Authors: Vuong N. Bui, Haruko Ogawa, Lai H. Ngo, Tugsbaatar Baatartsogt, Lary N. B. Abao, Shio Tamaki, Keisuke Saito, Yukiko Watanabe, Jonathan Runstadler, Kunitoshi Imai

Published in: Archives of Virology | Issue 2/2013

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Abstract

An H5N1 highly pathogenic avian influenza virus was isolated from conjunctiva of a whooper swan with neurological signs, which was captured during the latest H5N1 HPAI outbreak in Japan. The conjunctival swab contained a larger amount of the virus in comparison with the tracheal swab. This is the first report on H5N1 virus isolation from the conjunctiva of a wild bird, and the result may suggest the conjunctival swab to be a critical sample for H5N1 HPAIV detection in waterfowl. Phylogenetic analysis of the HA gene indicated that the virus falls into H5N1 clade 2.3.2.1.
Literature
1.
Brown JD, Stallknecht DE, Beck JR, Suarez DL, Swayne DE (2006) Susceptibility of North American ducks and gulls to H5N1 highly pathogenic avian influenza viruses. Emerg Infect Dis 12:1663–1670PubMedCrossRef
2.
Brown JD, Stallknecht DE, Swayne DE (2008) Experimental infection of swans and geese with highly pathogenic avian influenza virus (H5N1) of Asian lineage. Emerg Infect Dis 14:136–142PubMedCrossRef
3.
Bui VN, Ogawa H, Xininigen Karibe K, Matsuo K, Awad SS, Minoungou GL, Yoden S, Haneda H, Ngo LH, Tamaki S, Yamamoto Y, Nakamura K, Saito K, Watanabe Y, Runstadler J, Huettmann F, Happ GM, Imai K (2012) H4N8 subtype avian influenza virus isolated from shorebirds contains a unique PB1 gene and causes severe respiratory disease in mice. Virology 423:77–88PubMedCrossRef
4.
Chan PK (2002) Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clin Infect Dis 34(Suppl 2):S58–S64PubMedCrossRef
5.
Chen H, Smith GJ, Zhang SY, Qin K, Wang J, Li KS, Webster RG, Peiris JS, Guan Y (2005) Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436:191–192PubMedCrossRef
6.
Ellström P, Latorre-Margalef N, Griekspoor P, Waldenström J, Olofsson J, Wahlgren J, Olsen B (2008) Sampling for low-pathogenic avian influenza A virus in wild Mallard ducks: oropharyngeal versus cloacal swabbing. Vaccine 26:4414–4416PubMedCrossRef
7.
Keawcharoen J, van Riel D, van Amerongen G, Bestebroer T, Beyer WE, van Lavieren R, Osterhaus AD, Fouchier RA, Kuiken T (2008) Wild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis 14:600–607PubMedCrossRef
8.
Lee MS, Chang PC, Shien JH, Cheng MC, Shieh HK (2001) Identification and subtyping of avian influenza viruses by reverse transcription-PCR. J Virol Methods 97:13–22PubMedCrossRef
9.
Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang XW, Zhang XL, Zhao D, Wang G, Feng Y, Ma J, Liu W, Wang J, Gao GF (2005) Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309:1206PubMedCrossRef
10.
Long JX, Peng DX, Liu YL, Wu YT, Liu XF (2008) Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene. Virus Genes 36:471–478PubMedCrossRef
11.
Nakamura K, Imada T, Imai K, Yamamoto Y, Tanimura N, Yamada M, Mase M, Tsukamoto K, Yamaguchi S (2008) Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004. Avian Dis 52:8–13PubMedCrossRef
12.
Olsen B, Munster VJ, Wallensten A, Waldenstrom J, Osterhaus AD, Fouchier RA (2006) Global patterns of influenza a virus in wild birds. Science 312:384–388PubMedCrossRef
13.
Qiu BF, Liu WJ, Peng DX, Hu SL, Tang YH, Liu XF (2009) A reverse transcription-PCR for subtyping of the neuraminidase of avian influenza viruses. J Virol Methods 155:193–198PubMedCrossRef
14.
Saito K (2011) Outbreak of HPAI on wild birds in Hokkaido Japan, and information sharing of infectious diseases. In: The 27th International Symposium in Regional Research Institute of Agricultural Production, Fujisawa, Japan, (Abstract available upon requests)
15.
Sakai-Tagawa Y, Ozawa M, Tamura D, Le MQ, Nidom CA, Sugaya N, Kawaoka Y (2010) Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses. J Clin Microbiol 48:2872–2877PubMedCrossRef
16.
Sakoda Y, Ito H, Uchida Y, Okamatsu M, Yamamoto N, Soda K, Nomura N, Kuribayashi S, Shichinohe S, Sunden Y, Umemura T, Usui T, Ozaki H, Yamaguchi T, Murase T, Ito T, Saito T, Takada A, Kida H (2012) Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010–2011 winter season in Japan. J Gen Virol 93:541–550PubMedCrossRef
17.
Sturm-Ramirez KM, Ellis T, Bousfield B, Bissett L, Dyrting K, Rehg JE, Poon L, Guan Y, Peiris M, Webster RG (2004) Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol 78:4892–4901PubMedCrossRef
18.
Sturm-Ramirez KM, Hulse-Post DJ, Govorkova EA, Humberd J, Seiler P, Puthavathana P, Buranathai C, Nguyen TD, Chaisingh A, Long HT, Naipospos TS, Chen H, Ellis TM, Guan Y, Peiris JS, Webster RG (2005) Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? J Virol 79:11269–11279PubMedCrossRef
19.
20.
Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56:152–179PubMed
Metadata
Title
H5N1 highly pathogenic avian influenza virus isolated from conjunctiva of a whooper swan with neurological signs
Authors
Vuong N. Bui
Haruko Ogawa
Lai H. Ngo
Tugsbaatar Baatartsogt
Lary N. B. Abao
Shio Tamaki
Keisuke Saito
Yukiko Watanabe
Jonathan Runstadler
Kunitoshi Imai
Publication date
01-02-2013
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 2/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1502-9

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