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Archives of Virology
Published in: Archives of Virology 9/2012

01-09-2012 | Rapid Communication

Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia

Authors: Awatef El Moussi, Juan Ledesma, Mohamed Ali Ben Hadj Kacem, Francisco Pozo, Maria Teresa Cuevas, Moncef Hamdoun, Inmaculada Casas, Pilar Perez-Breña, Amine Slim

Published in: Archives of Virology | Issue 9/2012

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Abstract

Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.
Literature
1.
Kilander A, Rykkvin R, Dudman SG , Hungnes O (2010) Observed association between HA1 mutation D222G in the 2009 pandemic influenza A (H1N1) virus and severe clinical outcome, Norway 2009–2010. Euro Surveill 15. pii: 19498
2.
3.
4.
Puzelli S, Facchini M, Spagnolo D, De Marco MA, Calzoletti L, Zanetti A et al (2010) Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus. Emerg Infec Dis 16:863–865CrossRef
5.
Stevens J, Blixt O, Glaser L, Taubenberger JK, Palese P, Paulson JC et al (2006) Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Mol Biol 355:1143–1155PubMedCrossRef
6.
Chutinimitkul S, Herfst S, Steel J, Lowen AC, Ye J et al (2010) Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding. J Virol 84:11802–11813PubMedCrossRef
7.
Liu Y, Childs RA, Matrosovich T, Wharton S, Palma AS et al (2010) Altered receptor specificity and cell tropism of D222G hemagglutinin mutants isolated from fatal cases of pandemic A(H1N1) 2009 influenza virus. J Virol 84:12069–12074PubMedCrossRef
8.
Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T et al (2012) Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010. PLoSOne 7:e30946
9.
Ruiz-Carrascoso G, Casas I, Pozo F, Perez-Gonzalez C, Reina J, Perez-Brena P (2010) Development and implementation of influenza A virus subtyping and detection of genotypic resistance to neuraminidase inhibitors. J Med Virol 82:843–853PubMedCrossRef
10.
11.
Melidou A, Gioula G, Exindari M, Chatzidimitriou D, Diza E, Malisiovas N (2010) Molecular and phylogenetic analysis of the haemagglutinin gene of pandemic influenza H1N1 2009 viruses associated with severe and fatal infections. Virus Res 151:192–199PubMedCrossRef
12.
Potdar VA, Chadha MS, Jadhav SM, Mullick J, Cherian SS, Mishra AC (2010) Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India. PlosOne 5:e9693
Metadata
Title
Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia
Authors
Awatef El Moussi
Juan Ledesma
Mohamed Ali Ben Hadj Kacem
Francisco Pozo
Maria Teresa Cuevas
Moncef Hamdoun
Inmaculada Casas
Pilar Perez-Breña
Amine Slim
Publication date
01-09-2012
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 9/2012
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1349-0

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