Skip to main content
Top
Published in: Acta Diabetologica 2/2010

Open Access 01-06-2010 | Original Article

Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil

Authors: Ana Beatriz Valverde Mendes, João Antônio Saraiva Fittipaldi, Raimundo Celestino Silva Neves, Antônio Roberto Chacra, Edson Duarte Moreira Jr

Published in: Acta Diabetologica | Issue 2/2010

Login to get access

Abstract

Diabetes is a significant public health burden on the basis of its increased incidence, morbidity, and mortality. This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA1c) was measured by high-performance liquid chromatography in a central laboratory. Patients with HbA1c ≥ 7 were considered to have inadequate glycaemic control. Overall 6,701 patients were surveyed, 979 (15%) with type 1 and 5,692 (85%) with type 2 diabetes. The prevalence of inadequate glycaemic control was 76%. Poor glycaemic control was more common in patients with type 1 diabetes (90%) than in those with type 2 (73%), P < 0.001. Characteristics significantly associated with improved glycaemic control included: fewer years of diabetes duration, multi professional care, participation in a diabetes health education program, and satisfaction with current diabetes treatment. Despite increased awareness of the benefits of tight glycaemic control, we found that few diabetic patients in Brazil met recommended glycaemic control targets. This may contribute to increased rates of diabetic complications, which may impact health care costs. Our data support the public health message of implementation of early, aggressive management of diabetes.
Appendix
Available only for authorised users
Literature
1.
go back to reference Narayan KM, Gregg EW, Fagot-Campagna A, Engelgau MM, Vinicor F (2000) Diabetes—a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract 50(Suppl 2):S77–S84CrossRefPubMed Narayan KM, Gregg EW, Fagot-Campagna A, Engelgau MM, Vinicor F (2000) Diabetes—a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract 50(Suppl 2):S77–S84CrossRefPubMed
2.
go back to reference Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053CrossRefPubMed Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053CrossRefPubMed
3.
go back to reference Yach D, Stuckler D, Brownell KD (2006) Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 12:62–66CrossRefPubMed Yach D, Stuckler D, Brownell KD (2006) Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 12:62–66CrossRefPubMed
4.
go back to reference Park JS, Cho MH, Nam JS, Ahn CW, Cha BS, Lee EJ et al (2009) Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. Acta Diabetol. doi:10.1007/s00592-009-0125-4 Park JS, Cho MH, Nam JS, Ahn CW, Cha BS, Lee EJ et al (2009) Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. Acta Diabetol. doi:10.​1007/​s00592-009-0125-4
5.
go back to reference Deepa R, Pradeepa R, Shanthirani CS, Mohan V (2004) Association of hypertension with cluster of insulin resistance syndrome factors: the Chennai Urban Population Study (CUPS-12). Acta Diabetol 41:49–55CrossRefPubMed Deepa R, Pradeepa R, Shanthirani CS, Mohan V (2004) Association of hypertension with cluster of insulin resistance syndrome factors: the Chennai Urban Population Study (CUPS-12). Acta Diabetol 41:49–55CrossRefPubMed
6.
go back to reference Raman R, Rani PK, Gnanamoorthy P, Sudhir RR, Kumaramanikavel G, Sharma T (2009) Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8). Acta Diabetol. doi:10.1007/s00592-009-0113-8 Raman R, Rani PK, Gnanamoorthy P, Sudhir RR, Kumaramanikavel G, Sharma T (2009) Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8). Acta Diabetol. doi:10.​1007/​s00592-009-0113-8
7.
go back to reference No Authors (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977–86 No Authors (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977–86
8.
go back to reference No Authors (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837–53 No Authors (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837–53
9.
go back to reference American Association of Clinical Endocrinologists (2002) American College of Endocrinology consensus statement on guidelines for glycemic control. Endocr Pract 8:5–11 American Association of Clinical Endocrinologists (2002) American College of Endocrinology consensus statement on guidelines for glycemic control. Endocr Pract 8:5–11
10.
go back to reference Ahmad Khan H (2007) Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients. Acta Diabetol 44:193–200CrossRefPubMed Ahmad Khan H (2007) Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients. Acta Diabetol 44:193–200CrossRefPubMed
11.
go back to reference Ben Abdelaziz A, Soltane I, Gaha K, Thabet H, Tlili H, Ghannem H (2006) Predictive factors of glycemic control in patients with type 2 diabetes mellitus in primary health care. Rev Epidemiol Sante Publique 54:443–452CrossRefPubMed Ben Abdelaziz A, Soltane I, Gaha K, Thabet H, Tlili H, Ghannem H (2006) Predictive factors of glycemic control in patients with type 2 diabetes mellitus in primary health care. Rev Epidemiol Sante Publique 54:443–452CrossRefPubMed
12.
go back to reference Fox KM, Gerber Pharmd RA, Bolinder B, Chen J, Kumar S (2006) Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: a series of retrospective analyses of data from 1998 through 2002. Clin Ther 28:388–395CrossRefPubMed Fox KM, Gerber Pharmd RA, Bolinder B, Chen J, Kumar S (2006) Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: a series of retrospective analyses of data from 1998 through 2002. Clin Ther 28:388–395CrossRefPubMed
13.
go back to reference Harris SB, Ekoe JM, Zdanowicz Y, Webster-Bogaert S (2005) Glycemic control and morbidity in the Canadian primary care setting (results of the diabetes in Canada evaluation study). Diabetes Res Clin Pract 70:90–97CrossRefPubMed Harris SB, Ekoe JM, Zdanowicz Y, Webster-Bogaert S (2005) Glycemic control and morbidity in the Canadian primary care setting (results of the diabetes in Canada evaluation study). Diabetes Res Clin Pract 70:90–97CrossRefPubMed
14.
go back to reference Jorgensen LG, Petersen PH, Heickendorff L, Moller HJ, Hendel J, Christensen C et al (2005) Glycemic control in diabetes in three Danish counties. Clin Chem Lab Med 43:1366–1372CrossRefPubMed Jorgensen LG, Petersen PH, Heickendorff L, Moller HJ, Hendel J, Christensen C et al (2005) Glycemic control in diabetes in three Danish counties. Clin Chem Lab Med 43:1366–1372CrossRefPubMed
15.
go back to reference Koro CE, Bowlin SJ, Bourgeois N, Fedder DO (2004) Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report. Diabetes Care 27:17–20CrossRefPubMed Koro CE, Bowlin SJ, Bourgeois N, Fedder DO (2004) Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report. Diabetes Care 27:17–20CrossRefPubMed
16.
go back to reference Leinung MC, Gianoukakis AG, Lee DW, Jeronis SL, Desemone J (2000) Comparison of diabetes care provided by an endocrinology clinic and a primary-care clinic. Endocr Pract 6:361–366PubMed Leinung MC, Gianoukakis AG, Lee DW, Jeronis SL, Desemone J (2000) Comparison of diabetes care provided by an endocrinology clinic and a primary-care clinic. Endocr Pract 6:361–366PubMed
17.
go back to reference Otieno CF, Kariuki M, Ng’ang’a L (2003) Quality of glycaemic control in ambulatory diabetics at the out-patient clinic of Kenyatta National Hospital, Nairobi. East Afr Med J 80:406–410PubMed Otieno CF, Kariuki M, Ng’ang’a L (2003) Quality of glycaemic control in ambulatory diabetics at the out-patient clinic of Kenyatta National Hospital, Nairobi. East Afr Med J 80:406–410PubMed
18.
go back to reference Pittrow D, Stalla GK, Zeiher AM, Silber S, Marz W, Pieper L et al (2006) Prevalence, drug treatment and metabolic control of diabetes mellitus in primary care. Med Klin (Munich) 101:635–644CrossRef Pittrow D, Stalla GK, Zeiher AM, Silber S, Marz W, Pieper L et al (2006) Prevalence, drug treatment and metabolic control of diabetes mellitus in primary care. Med Klin (Munich) 101:635–644CrossRef
19.
go back to reference Saydah SH, Fradkin J, Cowie CC (2004) Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291:335–342CrossRefPubMed Saydah SH, Fradkin J, Cowie CC (2004) Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291:335–342CrossRefPubMed
20.
go back to reference Shah BR, Hux JE, Laupacis A, Mdcm BZ, Austin PC, van Walraven C (2005) Diabetic patients with prior specialist care have better glycaemic control than those with prior primary care. J Eval Clin Pract 11:568–575CrossRefPubMed Shah BR, Hux JE, Laupacis A, Mdcm BZ, Austin PC, van Walraven C (2005) Diabetic patients with prior specialist care have better glycaemic control than those with prior primary care. J Eval Clin Pract 11:568–575CrossRefPubMed
21.
go back to reference Tutuncuoglu P, Sarac F, Saygili F, Ozgen AG, Yilmaz C, Tuzun M (2008) Diabetes and impaired glucose tolerance prevalences in Turkish patients with impaired fasting glucose. Acta Diabetol 45:151–156CrossRefPubMed Tutuncuoglu P, Sarac F, Saygili F, Ozgen AG, Yilmaz C, Tuzun M (2008) Diabetes and impaired glucose tolerance prevalences in Turkish patients with impaired fasting glucose. Acta Diabetol 45:151–156CrossRefPubMed
22.
go back to reference Malerbi DA, Franco LJ (1992) Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30–69 yr. The Brazilian Cooperative Group on the Study of Diabetes Prevalence. Diabetes Care 15:1509–1516CrossRefPubMed Malerbi DA, Franco LJ (1992) Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30–69 yr. The Brazilian Cooperative Group on the Study of Diabetes Prevalence. Diabetes Care 15:1509–1516CrossRefPubMed
23.
go back to reference von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457CrossRef von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457CrossRef
24.
go back to reference American Diabetes Association (2003) Standards of medical care for patients with diabetes mellitus. Diabetes Care 26(Suppl 1):S33–50 American Diabetes Association (2003) Standards of medical care for patients with diabetes mellitus. Diabetes Care 26(Suppl 1):S33–50
25.
go back to reference Hoerger TJ, Segel JE, Gregg EW, Saaddine JB (2008) Is glycemic control improving in U.S. adults? Diabetes Care 31:81–86CrossRefPubMed Hoerger TJ, Segel JE, Gregg EW, Saaddine JB (2008) Is glycemic control improving in U.S. adults? Diabetes Care 31:81–86CrossRefPubMed
26.
go back to reference Goudswaard AN, Stolk RP, Zuithoff P, Rutten GE (2004) Patient characteristics do not predict poor glycaemic control in type 2 diabetes patients treated in primary care. Eur J Epidemiol 19:541–545CrossRefPubMed Goudswaard AN, Stolk RP, Zuithoff P, Rutten GE (2004) Patient characteristics do not predict poor glycaemic control in type 2 diabetes patients treated in primary care. Eur J Epidemiol 19:541–545CrossRefPubMed
27.
go back to reference Hawthorne K, Tomlinson S (1999) Pakistani moslems with Type 2 diabetes mellitus: effect of sex, literacy skills, known diabetic complications and place of care on diabetic knowledge, reported self-monitoring management and glycaemic control. Diabet Med 16:591–597CrossRefPubMed Hawthorne K, Tomlinson S (1999) Pakistani moslems with Type 2 diabetes mellitus: effect of sex, literacy skills, known diabetic complications and place of care on diabetic knowledge, reported self-monitoring management and glycaemic control. Diabet Med 16:591–597CrossRefPubMed
28.
go back to reference Salcedo-Rocha AL, Garcia de Alba-Garcia JE, Frayre-Torres MJ, Lopez-Coutino B (2008) Gender and metabolic control of type 2 diabetes among primary care patients. Rev Med Inst Mex Seguro Soc 46:73–81PubMed Salcedo-Rocha AL, Garcia de Alba-Garcia JE, Frayre-Torres MJ, Lopez-Coutino B (2008) Gender and metabolic control of type 2 diabetes among primary care patients. Rev Med Inst Mex Seguro Soc 46:73–81PubMed
29.
go back to reference Tabak AG, Tamas G, Zgibor J, Wilson R, Becker D, Kerenyi Z et al (2000) Targets and reality: a comparison of health care indicators in the U.S. (Pittsburgh Epidemiology of Diabetes Complications Study) and Hungary (DiabCare Hungary). Diabetes Care 23:1284–1289CrossRefPubMed Tabak AG, Tamas G, Zgibor J, Wilson R, Becker D, Kerenyi Z et al (2000) Targets and reality: a comparison of health care indicators in the U.S. (Pittsburgh Epidemiology of Diabetes Complications Study) and Hungary (DiabCare Hungary). Diabetes Care 23:1284–1289CrossRefPubMed
30.
go back to reference Zgibor JC, Songer TJ, Kelsey SF, Weissfeld J, Drash AL, Becker D et al (2000) The association of diabetes specialist care with health care practices and glycemic control in patients with type 1 diabetes: a cross-sectional analysis from the Pittsburgh epidemiology of diabetes complications study. Diabetes Care 23:472–476CrossRefPubMed Zgibor JC, Songer TJ, Kelsey SF, Weissfeld J, Drash AL, Becker D et al (2000) The association of diabetes specialist care with health care practices and glycemic control in patients with type 1 diabetes: a cross-sectional analysis from the Pittsburgh epidemiology of diabetes complications study. Diabetes Care 23:472–476CrossRefPubMed
31.
go back to reference Cavanaugh K, Huizinga MM, Wallston KA, Gebretsadik T, Shintani A, Davis D et al (2008) Association of numeracy and diabetes control. Ann Intern Med 148:737–746PubMed Cavanaugh K, Huizinga MM, Wallston KA, Gebretsadik T, Shintani A, Davis D et al (2008) Association of numeracy and diabetes control. Ann Intern Med 148:737–746PubMed
32.
go back to reference Roblin DW, Ntekop E, Becker ER (2007) Improved intermediate clinical outcomes from participation in a diabetes health education program. J Ambul Care Manag 30:64–73 Roblin DW, Ntekop E, Becker ER (2007) Improved intermediate clinical outcomes from participation in a diabetes health education program. J Ambul Care Manag 30:64–73
33.
go back to reference Ishii H, Anderson JH Jr, Yamamura A, Takeuchi M, Ikeda I (2008) Improvement of glycemic control and quality-of-life by insulin lispro therapy: assessing benefits by ITR-QOL questionnaires. Diabetes Res Clin Pract 81:169–178CrossRefPubMed Ishii H, Anderson JH Jr, Yamamura A, Takeuchi M, Ikeda I (2008) Improvement of glycemic control and quality-of-life by insulin lispro therapy: assessing benefits by ITR-QOL questionnaires. Diabetes Res Clin Pract 81:169–178CrossRefPubMed
34.
go back to reference Chisalita SI, Lindstrom T, Eson Jennersjo P, Paulsson JF, Westermark GT, Olsson AG et al (2009) Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control. Acta Diabetol 46:35–42CrossRefPubMed Chisalita SI, Lindstrom T, Eson Jennersjo P, Paulsson JF, Westermark GT, Olsson AG et al (2009) Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control. Acta Diabetol 46:35–42CrossRefPubMed
35.
go back to reference Rosenstock J, Cappelleri JC, Bolinder B, Gerber RA (2004) Patient satisfaction and glycemic control after 1 year with inhaled insulin (Exubera) in patients with type 1 or type 2 diabetes. Diabetes Care 27:1318–1323CrossRefPubMed Rosenstock J, Cappelleri JC, Bolinder B, Gerber RA (2004) Patient satisfaction and glycemic control after 1 year with inhaled insulin (Exubera) in patients with type 1 or type 2 diabetes. Diabetes Care 27:1318–1323CrossRefPubMed
36.
go back to reference De Mattia G, Laurenti O, Moretti A (2009) Comparison of glycaemic control in patients with type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study. Acta Diabetol 46:67–73CrossRefPubMed De Mattia G, Laurenti O, Moretti A (2009) Comparison of glycaemic control in patients with type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study. Acta Diabetol 46:67–73CrossRefPubMed
Metadata
Title
Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil
Authors
Ana Beatriz Valverde Mendes
João Antônio Saraiva Fittipaldi
Raimundo Celestino Silva Neves
Antônio Roberto Chacra
Edson Duarte Moreira Jr
Publication date
01-06-2010
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 2/2010
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-009-0138-z

Other articles of this Issue 2/2010

Acta Diabetologica 2/2010 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.