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Supportive Care in Cancer
Published in: Supportive Care in Cancer 3/2021

01-03-2021 | Graft-Versus-Host Disease | Original Article

Chronic oral graft-versus-host disease: induction and maintenance therapy with photobiomodulation therapy

Authors: Joel B. Epstein, Judith E. Raber-Durlacher, Geena L. Epstein, Mette D. Hazenberg, Dimitrios Tzachanis, Ricardo T. Spielberger

Published in: Supportive Care in Cancer | Issue 3/2021

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Abstract

Abstract

This study presents follow-up of a prior study of patients with chronic symptomatic oral chronic graft-versus-host-disease (cGVHD) managed with photobiomodulation therapy (PBM therapy for 1 month. Here, we report long-term follow-up of a series of patients where PBM therapy in patients with oral cGVHD for maintenance follows the initial period of PBM therapy for continuing management.

Patients and methods

We report continuing follow-up of 7 cases of oral cGVHD that were treated with PBM therapy. PBM therapy was continued in these patients with the goal of determining the best management schedule of PBM to maintain or improve control of each patient’s symptoms and signs of oral cGVHD.

Results

Oral sensitivity and mucosal changes of cGVHD were controlled with a continuing schedule of PBM therapy of up to 6–8-week treatment intervals in patients with continuing GVHD. These findings suggest that PBM therapy represents an additional approach for continuing management of oral cGVHD and that the frequency of treatment should be individualized for each patient to provide best control of oral findings. In one case weekly PBM treatment was continued, while in others, management on a monthly or bimonthly basis was associated with control of the oral condition. PBM may be individualized and provided based upon best control of the symptoms and signs of oral GVHD.
Literature
1.
Meier JK, Wolff D, Pavletic S, Greinix H, Gosau M, Bertz H, Lee SJ, Lawitschka A, Elad S, International Consensus Conference on Clinical Practice in cGVHD (2011) Oral chronic graft-versus-host disease: report from the international consensus conference on clinical practice in cGVHD. Clin Oral Invest 15(2):127–139CrossRef
2.
Epstein JB, Raber-Durlacher JE, Lill M, Linhares YP et al (2017) Photobiomodulation therapy in management of chronic oral graft-versus-host-disease. Support Care Cancer 25(2):357–364CrossRef
3.
Imanguli MM, Atkinson JC, Harvey KE, Hoehn GT, Ryu OH, Wu T, Kingman A, Barrett AJ, Bishop MR, Childs RW, Fowler DH, Pavletic SZ, Hart TC (2007) Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp Hematol 35(2):184–192CrossRef
4.
Oberoi S, Zamperlini-Netto G, Beyene J, Treister NS, Sung L (2014) Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLoS One 9(9):e107418CrossRef
5.
Stoopler ET (2013) Management of oral chronic graft-versus-host disease. Journal 79:d37
6.
Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD (2011) Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review. Photomed Laser Surg 29(6):365–381CrossRef
7.
Migliorati C, Hewson I, Lalla RV, Antunes HS, Estilo CL, Hodgson B et al (2013) Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Support Care Cancer 21(1):333–341CrossRef
8.
Woodruff LD, Bounkeo JM, Brannon WM, Dawes KS, Barham CD, Waddell DL, Enwemeka CS (2001) The efficacy of laser therapy in wound repair: a meta-analysis of the literature. Photomed Laser Surg 22(3):241–247CrossRef
9.
Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Sonis ST, Elad S et al (2016) Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations. Support Care Cancer 24(6):2781–2792CrossRef
10.
Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR et al (2016) Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Support Care Cancer 24(6):2793–2805CrossRef
11.
Fillipin LI, Mauriz JL, Vedovelli K, Moreira AJ, Zettler CG, Lech O, Marroni NP, González-Gallego J (2005) Low-level laser therapy (LLLT) prevents oxidative stress and reduces fibrosis in rat traumatized Achilles tendon. Lasers SurgMed 37(4):293–300CrossRef
12.
Dillenburg CS, Martins MA, Munerato MC et al (2014) Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. J Biomed Opt 19:068002CrossRef
13.
Othman NA, Shaker OG, Elshenawy HM et al (2016) The effect of diode laser and topical steroid on serum level of TNF alpha in oral lichen planus patients. J Clin Exp Dent 8:e566–e570PubMedPubMedCentral
14.
Akram Z, Adbduljabbar T, Vohra F et al (2018) Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: A systematic review. J Oral Pathol Med 47:11–17CrossRef
15.
Al-Maweri SA, Asjraf S, Kalakonda B et al (2018) Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: a systematic review. J Oral Pathol Med 47:326–332CrossRef
16.
Lee SJ (2017) Classification systems for chronic graft-versus-host disease. Blood 129(1):30–37CrossRef
17.
Elad S, Arany P, Bensadoun RJ, Epstein JB et al (2018) Photobiomodulation therapy in the management of oral mucositis: Search for the optimal clinical treatment parameters. Support Care Cancer 26:3319–3321CrossRef
18.
Zadik Y, Arany PR, Fregnani ER, Bossi P, Antunes HS, Bensadoun R-J et al (2019 Oct) Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 27(10):3969–3983CrossRef
19.
Cafaro A, Arduino PG, Massolini G, Romagnoli E, Broccoletti R (2014) Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers Med Sci 29(1):185–190CrossRef
20.
Barros de Ameida E, Da Mota Vasconcelos Brasil C, Serpa M, Correia A, Da Rosa M, De Castro J (2014) Low-level laser therapy in oral graft-versus-host disease. Oral Surg Oral Med Oral Pathol Oral Radiol 117:e214–e215CrossRef
21.
Cafaro A, Cambino A, Conrotto D, Broccoletti R, Arduino P (2014) Low level laser therapy in oral graft versus host disease; a case report. Ann Stomatol 2014(suppl 3):2 14
22.
Chor A, de Azevedo AM, Maiolino A, Nucci M (2004) Successful treatment of oral lesions of chronic lichenoid graft-vs.-host disease by the addition of low-level laser therapy to systemic immunosuppression. Europ J Haematol 72(3):222–224CrossRef
23.
Chor A, Sotero Caio AB, de Azevedo AM (2001) The irreplaceable image: amelioration of oral mucosal lesions of acute graft-versus-host disease by low-level laser therapy. Haematologica 86(12):1321PubMed
24.
Epstein JB, Raber-Durlacher JE, Huysmans MC, Schoordijk MCE, Cheng JE, Bensadoun RJ, Arany PR (2018) Photobiomodulation therapy alleviates tissue fibroses associated with chronic graft-versus-host disease: two case reports and putative anti-fibrotic roles of TGF-B. Photomed Laser Surg 36(2):92–99CrossRef
25.
Loncar B, Stipetic MM, Baricevic M, Risovic D (2011) The effect of low-level laser therapy on salivary glands in patients with xerostomia. Photomed Laser Surg 29(3):171–175CrossRef
26.
Vidovic Juras D, Lukac J, Cekic-Arambasin A, Vidovic A, Canjuga I, Sikora M et al (2010) Effects of low-level laser treatment on mouth dryness. Collegium Antropologicum 34(3):1039–1043PubMed
27.
Plavnik LM, De Crosa ME, Malberti AI (2003) Effect of low-power radiation (helium/neon) upon submandibulary glands. J Clin Laser Med Surg 21(4):219–225CrossRef
28.
Takeda Y (1988) Irradiation effect of low-energy laser on rat submandibular salivary gland. J O Pathol 17(2):91–94CrossRef
29.
Cowen D, Tardieu C, Schubert M, Peterson D, Resbeut M, Faucher C, Franquin JC (1997) Low energy helium-neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: results of a double blind randomized trial. Int J Radiat Oncol Biol Phys 38(4):697–703CrossRef
30.
Arbabi-Kalati F, Arbabi-Kalati F, Moridi T (2013) Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis. Acta Medica Iranica 51(3):157–162PubMed
31.
Oton-Leite AF, Elias LS, Morais MO, Pinezi JC, Leles CR, Silva MA, Mendonca EF (2013) Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. Spec CareDent 33(6):294–300
32.
Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, Haddad R, Antin JH, Soiffer R, Treister N (2011) Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant 46(6):884–891CrossRef
Metadata
Title
Chronic oral graft-versus-host disease: induction and maintenance therapy with photobiomodulation therapy
Authors
Joel B. Epstein
Judith E. Raber-Durlacher
Geena L. Epstein
Mette D. Hazenberg
Dimitrios Tzachanis
Ricardo T. Spielberger
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 3/2021
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-020-05626-3

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