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Published in: European Journal of Pediatrics 8/2023

Open Access 30-05-2023 | Ultrasound | REVIEW

Real-time MRI: a new tool of radiologic imaging in small children

Authors: Franz Wolfgang Hirsch, Jens Frahm, Ina Sorge, Dirk Klee, Freerk Prenzel, Matthias Krause, Martin Lacher, Dirk Voit, Daniel Gräfe

Published in: European Journal of Pediatrics | Issue 8/2023

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Abstract

Real-time MRI (rt-MRI) in children is a new imaging technique that combines the advantages of US — at frame rates of up to 50 images per second — with the quality and features of MRI. Although still subject of research, it has become a standard tool in the diagnostic portfolio of two pediatric radiology departments in Germany. Based on ultrashort acquisition times, any detrimental effects of macroscopic movements of the child and the physiological movements of the organs are negligible. Especially in pediatric brain imaging, rt-MRI has already proven its value. With suitable indications, rt-MRI can reduce anesthesia and sedation examinations in children below 6 years of age by 40% due to its very short examination time and its robustness to motion. There is a high level of acceptance among parents and referrers when diagnostic possibilities and limitations are communicated correctly.
Conclusion: Completely new diagnostic possibilities arise in the imaging of the moving lung, the beating heart, joint movements, and speaking and swallowing, as demonstrated in this video-backed review.
What is known:
MRI in moving children has been burdened with severe artifacts.
Gross motion usually has to be handled by sedation and periodic motion of the heart and lungs has to be compensated with time-consuming techniques until now.
What is new:
Real-time MRI allows image acquisition with up to 50 frames per second similar to ultrasound frame rate.
Real-time MRI proofs to be very promising for imaging children, reducing examination time and sedation rate drastically.
Appendix
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Literature
1.
go back to reference Uecker M, Zhang S, Voit D, Karaus A, Merboldt KD, Frahm J (2010) Real-time MRI at a resolution of 20 ms. NMR Biomed 23:986–994CrossRefPubMed Uecker M, Zhang S, Voit D, Karaus A, Merboldt KD, Frahm J (2010) Real-time MRI at a resolution of 20 ms. NMR Biomed 23:986–994CrossRefPubMed
2.
go back to reference Zhang S, Joseph AA, Voit D, Schaetz S, Merboldt KD, Unterberg-Buchwald C, Hennemuth A, Lotz J, Frahm J (2014) Real-time magnetic resonance imaging of cardiac function and flow-recent progress. Quant Imaging Med Surg 4:313–329PubMedPubMedCentral Zhang S, Joseph AA, Voit D, Schaetz S, Merboldt KD, Unterberg-Buchwald C, Hennemuth A, Lotz J, Frahm J (2014) Real-time magnetic resonance imaging of cardiac function and flow-recent progress. Quant Imaging Med Surg 4:313–329PubMedPubMedCentral
3.
go back to reference Grafe D, Roth C, Weisser M, Krause M, Frahm J, Voit D, Hirsch FW (2020) Outpacing movement - ultrafast volume coverage in neuropediatric magnetic resonance imaging. Pediatr Radiol 50:1751–1756CrossRefPubMedPubMedCentral Grafe D, Roth C, Weisser M, Krause M, Frahm J, Voit D, Hirsch FW (2020) Outpacing movement - ultrafast volume coverage in neuropediatric magnetic resonance imaging. Pediatr Radiol 50:1751–1756CrossRefPubMedPubMedCentral
4.
go back to reference Hirsch FW, Frahm J, Sorge I, Roth C, Voit D, Grafe D (2021) Real-time magnetic resonance imaging in pediatric radiology - new approach to movement and moving children. Pediatr Radiol 51:840–846CrossRefPubMedPubMedCentral Hirsch FW, Frahm J, Sorge I, Roth C, Voit D, Grafe D (2021) Real-time magnetic resonance imaging in pediatric radiology - new approach to movement and moving children. Pediatr Radiol 51:840–846CrossRefPubMedPubMedCentral
5.
go back to reference Rower LM, Radke KL, Hussmann J, Malik H, Uelwer T, Voit D, Frahm J, Wittsack HJ, Harmeling S, Pillekamp F, Klee D (2022) Comparison of cardiac volumetry using real-time MRI during free-breathing with standard cine MRI during breath-hold in children. Pediatr Radiol 52:1462–1475CrossRefPubMedPubMedCentral Rower LM, Radke KL, Hussmann J, Malik H, Uelwer T, Voit D, Frahm J, Wittsack HJ, Harmeling S, Pillekamp F, Klee D (2022) Comparison of cardiac volumetry using real-time MRI during free-breathing with standard cine MRI during breath-hold in children. Pediatr Radiol 52:1462–1475CrossRefPubMedPubMedCentral
7.
go back to reference Dillman JR, Gee MS, Ward CG, Drum ET, States LJ (2021) Imaging sedation and anesthesia practice patterns in pediatric radiology departments - a survey of the Society of Chiefs of Radiology at Children’s Hospitals (SCORCH). Pediatr Radiol 51:1497–1502CrossRefPubMed Dillman JR, Gee MS, Ward CG, Drum ET, States LJ (2021) Imaging sedation and anesthesia practice patterns in pediatric radiology departments - a survey of the Society of Chiefs of Radiology at Children’s Hospitals (SCORCH). Pediatr Radiol 51:1497–1502CrossRefPubMed
8.
go back to reference Schaetz S, Voit D, Frahm J, Uecker M (2017) Accelerated computing in magnetic resonance imaging: real-time imaging using nonlinear inverse reconstruction. Comput Math Methods Med 2017:3527269CrossRefPubMedPubMedCentral Schaetz S, Voit D, Frahm J, Uecker M (2017) Accelerated computing in magnetic resonance imaging: real-time imaging using nonlinear inverse reconstruction. Comput Math Methods Med 2017:3527269CrossRefPubMedPubMedCentral
9.
go back to reference Frahm J, Voit D, Uecker M (2019) Real-time magnetic resonance imaging: radial gradient-echo sequences with nonlinear inverse reconstruction. Invest Radiol 54:757–766CrossRefPubMed Frahm J, Voit D, Uecker M (2019) Real-time magnetic resonance imaging: radial gradient-echo sequences with nonlinear inverse reconstruction. Invest Radiol 54:757–766CrossRefPubMed
10.
go back to reference Park J, Jang M, Heier L, Limperopoulos C, Zun Z (2022) Rapid anatomical imaging of the neonatal brain using T(2)-prepared 3D balanced steady-state free precession. Magn Reson Med Park J, Jang M, Heier L, Limperopoulos C, Zun Z (2022) Rapid anatomical imaging of the neonatal brain using T(2)-prepared 3D balanced steady-state free precession. Magn Reson Med
11.
go back to reference Gallo-Bernal S, Bedoya MA, Gee MS, Jaimes C (2022) Pediatric magnetic resonance imaging: faster is better. Pediatr Radiol Gallo-Bernal S, Bedoya MA, Gee MS, Jaimes C (2022) Pediatric magnetic resonance imaging: faster is better. Pediatr Radiol
12.
go back to reference Voit D, Kalentev O, Frahm J (2019) Body coil reference for inverse reconstructions of multi-coil data-the case for real-time MRI. Quant Imaging Med Surg 9:1815–1819CrossRefPubMedPubMedCentral Voit D, Kalentev O, Frahm J (2019) Body coil reference for inverse reconstructions of multi-coil data-the case for real-time MRI. Quant Imaging Med Surg 9:1815–1819CrossRefPubMedPubMedCentral
13.
go back to reference Voit D, Kalentev O, van Zalk M, Joseph AA, Frahm J (2020) Rapid and motion-robust volume coverage using cross-sectional real-time MRI. Magn Reson Med 83:1652–1658CrossRefPubMed Voit D, Kalentev O, van Zalk M, Joseph AA, Frahm J (2020) Rapid and motion-robust volume coverage using cross-sectional real-time MRI. Magn Reson Med 83:1652–1658CrossRefPubMed
14.
go back to reference Sorge I, Hirsch FW, Voit D, Frahm J, Krause M, Roth C, Zimmermann P, Grafe D (2022) Decreased need for anesthesia during ultra-fast cranial MRI in young children: one-year summary. Rofo 194:192–198CrossRefPubMed Sorge I, Hirsch FW, Voit D, Frahm J, Krause M, Roth C, Zimmermann P, Grafe D (2022) Decreased need for anesthesia during ultra-fast cranial MRI in young children: one-year summary. Rofo 194:192–198CrossRefPubMed
15.
go back to reference Rower LM, Uelwer T, Hussmann J, Malik H, Eichinger M, Voit D, Wielputz MO, Frahm J, Harmeling S, Klee D, Pillekamp F (2021) Spirometry-based reconstruction of real-time cardiac MRI: Motion control and quantification of heart-lung interactions. Magn Reson Med 86:2692–2702CrossRefPubMed Rower LM, Uelwer T, Hussmann J, Malik H, Eichinger M, Voit D, Wielputz MO, Frahm J, Harmeling S, Klee D, Pillekamp F (2021) Spirometry-based reconstruction of real-time cardiac MRI: Motion control and quantification of heart-lung interactions. Magn Reson Med 86:2692–2702CrossRefPubMed
16.
go back to reference Laubrock K, von Loesch T, Steinmetz M, Lotz J, Frahm J, Uecker M, Unterberg-Buchwald C (2022) Imaging of arrhythmia: real-time cardiac magnetic resonance imaging in atrial fibrillation. Eur J Radiol Open 9:100404CrossRefPubMedPubMedCentral Laubrock K, von Loesch T, Steinmetz M, Lotz J, Frahm J, Uecker M, Unterberg-Buchwald C (2022) Imaging of arrhythmia: real-time cardiac magnetic resonance imaging in atrial fibrillation. Eur J Radiol Open 9:100404CrossRefPubMedPubMedCentral
17.
go back to reference Kollmeier JM, Gurbuz-Reiss L, Sahoo P, Badura S, Ellebracht B, Keck M, Gartner J, Ludwig HC, Frahm J, Dreha-Kulaczewski S (2022) Deep breathing couples CSF and venous flow dynamics. Sci Rep 12:2568CrossRefPubMedPubMedCentral Kollmeier JM, Gurbuz-Reiss L, Sahoo P, Badura S, Ellebracht B, Keck M, Gartner J, Ludwig HC, Frahm J, Dreha-Kulaczewski S (2022) Deep breathing couples CSF and venous flow dynamics. Sci Rep 12:2568CrossRefPubMedPubMedCentral
18.
go back to reference Liszewski MC, Ciet P, Winant AJ, Lee EY (2022) Lung and large airway imaging: magnetic resonance imaging versus computed tomography. Pediatr Radiol 52:1814–1825CrossRefPubMed Liszewski MC, Ciet P, Winant AJ, Lee EY (2022) Lung and large airway imaging: magnetic resonance imaging versus computed tomography. Pediatr Radiol 52:1814–1825CrossRefPubMed
19.
go back to reference Seif Amir Hosseini A, Uhlig J, Streit U, Uhlig A, Sprenger T, Wedi E, Ellenrieder V, Ghadimi M, Uecker M, Voit D, Frahm J, Lotz J, Biggemann L (2019) Hiatal hernias in patients with GERD-like symptoms: evaluation of dynamic real-time MRI vs endoscopy. Eur Radiol 29:6653–6661CrossRefPubMed Seif Amir Hosseini A, Uhlig J, Streit U, Uhlig A, Sprenger T, Wedi E, Ellenrieder V, Ghadimi M, Uecker M, Voit D, Frahm J, Lotz J, Biggemann L (2019) Hiatal hernias in patients with GERD-like symptoms: evaluation of dynamic real-time MRI vs endoscopy. Eur Radiol 29:6653–6661CrossRefPubMed
20.
go back to reference Hirsch FW, Sorge I, Voit D, Frahm J, Prenzel F, Wachowiak R, Anders R, Roth C, Grafe D (2023) Chest examinations in children with real-time magnetic resonance imaging: first clinical experience. Pediatr Radiol 53:12–20CrossRefPubMed Hirsch FW, Sorge I, Voit D, Frahm J, Prenzel F, Wachowiak R, Anders R, Roth C, Grafe D (2023) Chest examinations in children with real-time magnetic resonance imaging: first clinical experience. Pediatr Radiol 53:12–20CrossRefPubMed
21.
go back to reference Hellwig SJ, Iltis PW, Joseph AA, Voit D, Frahm J, Schoonderwaldt E, Altenmuller E (2019) Tongue involvement in embouchure dystonia: new piloting results using real-time MRI of trumpet players. J Clin Mov Disord 6:5CrossRefPubMedPubMedCentral Hellwig SJ, Iltis PW, Joseph AA, Voit D, Frahm J, Schoonderwaldt E, Altenmuller E (2019) Tongue involvement in embouchure dystonia: new piloting results using real-time MRI of trumpet players. J Clin Mov Disord 6:5CrossRefPubMedPubMedCentral
22.
go back to reference Iltis PW, Frahm J, Voit D, Wood D, Taylor S (2022) Oral cavity movements of the tongue during large interval slurs in high-level horn players: a descriptive study. Med Probl Perform Art 37:89–97CrossRefPubMed Iltis PW, Frahm J, Voit D, Wood D, Taylor S (2022) Oral cavity movements of the tongue during large interval slurs in high-level horn players: a descriptive study. Med Probl Perform Art 37:89–97CrossRefPubMed
23.
go back to reference Biggemann L, Uhlig J, Gliem N, Al-Bourini O, Wedi E, Ellenrieder V, Ghadimi M, Uecker M, Frahm J, Lotz J, Hosseini ASA, Streit U (2020) Assessment of esophageal motility disorders by real-time MRI. Eur J Radiol 132:109265CrossRefPubMed Biggemann L, Uhlig J, Gliem N, Al-Bourini O, Wedi E, Ellenrieder V, Ghadimi M, Uecker M, Frahm J, Lotz J, Hosseini ASA, Streit U (2020) Assessment of esophageal motility disorders by real-time MRI. Eur J Radiol 132:109265CrossRefPubMed
24.
go back to reference Seif Amir Hosseini A, Uhlig J, Streit U, Gliem N, Wedi E, Ellenrieder V, Ghadimi M, Ahmed S, Uecker M, Frahm J, Lotz J, Biggemann L (2020) Real-time MRI for dynamic assessment of gastroesophageal reflux disease: comparison to pH-metry and impedance. Eur J Radiol 125:108856CrossRefPubMed Seif Amir Hosseini A, Uhlig J, Streit U, Gliem N, Wedi E, Ellenrieder V, Ghadimi M, Ahmed S, Uecker M, Frahm J, Lotz J, Biggemann L (2020) Real-time MRI for dynamic assessment of gastroesophageal reflux disease: comparison to pH-metry and impedance. Eur J Radiol 125:108856CrossRefPubMed
25.
go back to reference Seif Amir Hosseini A, Uhlig J, Streit U, Voit D, Uhlig A, Ellenrieder V, Ghadimi M, Sprenger T, Beham A, Uecker M, Frahm J, Lotz J, Biggemann L (2019) Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease. Eur Radiol 29:4691–4698CrossRefPubMed Seif Amir Hosseini A, Uhlig J, Streit U, Voit D, Uhlig A, Ellenrieder V, Ghadimi M, Sprenger T, Beham A, Uecker M, Frahm J, Lotz J, Biggemann L (2019) Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease. Eur Radiol 29:4691–4698CrossRefPubMed
26.
go back to reference Krohn S, Joseph AA, Voit D, Michaelis T, Merboldt KD, Buergers R, Frahm J (2019) Multi-slice real-time MRI of temporomandibular joint dynamics. Dentomaxillofac Radiol 48:20180162CrossRefPubMed Krohn S, Joseph AA, Voit D, Michaelis T, Merboldt KD, Buergers R, Frahm J (2019) Multi-slice real-time MRI of temporomandibular joint dynamics. Dentomaxillofac Radiol 48:20180162CrossRefPubMed
27.
go back to reference Lin CC, Zhang S, Hsu CY, Frahm J, Lu TW, Shih TF (2019) Measuring three-dimensional tibiofemoral kinematics using dual-slice real-time magnetic resonance imaging. Med Phys 46:4588–4599CrossRefPubMed Lin CC, Zhang S, Hsu CY, Frahm J, Lu TW, Shih TF (2019) Measuring three-dimensional tibiofemoral kinematics using dual-slice real-time magnetic resonance imaging. Med Phys 46:4588–4599CrossRefPubMed
28.
go back to reference Johnson MA, Gohel S, Mitchell SL, Flynn JJM, Baldwin KD (2021) Entire-spine magnetic resonance imaging findings and costs in children with presumed adolescent idiopathic scoliosis. J Pediatr Orthop 41:585–590CrossRefPubMed Johnson MA, Gohel S, Mitchell SL, Flynn JJM, Baldwin KD (2021) Entire-spine magnetic resonance imaging findings and costs in children with presumed adolescent idiopathic scoliosis. J Pediatr Orthop 41:585–590CrossRefPubMed
29.
go back to reference Grafe D, Lacher M, Martynov I, Hirsch FW, Voit D, Frahm J, Busse H, Sesia SB, Kramer S, Zimmermann P (2022) Pectus excavatum in motion: dynamic evaluation using real-time MRI. Eur Radiol Grafe D, Lacher M, Martynov I, Hirsch FW, Voit D, Frahm J, Busse H, Sesia SB, Kramer S, Zimmermann P (2022) Pectus excavatum in motion: dynamic evaluation using real-time MRI. Eur Radiol
Metadata
Title
Real-time MRI: a new tool of radiologic imaging in small children
Authors
Franz Wolfgang Hirsch
Jens Frahm
Ina Sorge
Dirk Klee
Freerk Prenzel
Matthias Krause
Martin Lacher
Dirk Voit
Daniel Gräfe
Publication date
30-05-2023
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 8/2023
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-023-04996-0

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