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01-09-2021 | Magnetic Resonance Imaging | Methods Paper

The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students

Authors: Ami Tsuchida, Alexandre Laurent, Fabrice Crivello, Laurent Petit, Marc Joliot, Antonietta Pepe, Naka Beguedou, Marie-Fateye Gueye, Violaine Verrecchia, Victor Nozais, Laure Zago, Emmanuel Mellet, Stéphanie Debette, Christophe Tzourio, Bernard Mazoyer

Published in: Brain Structure and Function | Issue 7/2021

Abstract

We report on MRi-Share, a multi-modal brain MRI database acquired in a unique sample of 1870 young healthy adults, aged 18–35 years, while undergoing university-level education. MRi-Share contains structural (T1 and FLAIR), diffusion (multispectral), susceptibility-weighted (SWI), and resting-state functional imaging modalities. Here, we described the contents of these different neuroimaging datasets and the processing pipelines used to derive brain phenotypes, as well as how quality control was assessed. In addition, we present preliminary results on associations of some of these brain image-derived phenotypes at the whole brain level with both age and sex, in the subsample of 1722 individuals aged less than 26 years. We demonstrate that the post-adolescence period is characterized by changes in both structural and microstructural brain phenotypes. Grey matter cortical thickness, surface area and volume were found to decrease with age, while white matter volume shows increase. Diffusivity, either radial or axial, was found to robustly decrease with age whereas fractional anisotropy only slightly increased. As for the neurite orientation dispersion and densities, both were found to increase with age. The isotropic volume fraction also showed a slight increase with age. These preliminary findings emphasize the complexity of changes in brain structure and function occurring in this critical period at the interface of late maturation and early ageing.

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Title: The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students
Authors: Ami Tsuchida
Alexandre Laurent
Fabrice Crivello
Laurent Petit
Marc Joliot
Antonietta Pepe
Naka Beguedou
Marie-Fateye Gueye
Violaine Verrecchia
Victor Nozais
Laure Zago
Emmanuel Mellet
Stéphanie Debette
Christophe Tzourio
Bernard Mazoyer
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Brain Structure and Function / Issue 7/2021
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02334-4

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The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students

Abstract

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Abstract

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