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Open Access 01-07-2021 | Cytokines | Original Article

Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

Authors: Zerbu Yasar, Bradley T. Elliott, Yvoni Kyriakidou, Chiazor T. Nwokoma, Ruth D. Postlethwaite, Christopher J. Gaffney, Susan Dewhurst, Lawrence D. Hayes

Published in: European Journal of Applied Physiology | Issue 7/2021

Abstract

Purpose

The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men.

Methods

Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group.

Results

Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL⁻¹ and 60 (12) pg mL⁻¹, respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL⁻¹ which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07).

Conclusion

Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.

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Title: Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
Authors: Zerbu Yasar
Bradley T. Elliott
Yvoni Kyriakidou
Chiazor T. Nwokoma
Ruth D. Postlethwaite
Christopher J. Gaffney
Susan Dewhurst
Lawrence D. Hayes
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Cytokines
Growth Factors
Growth Factors
Published in: European Journal of Applied Physiology / Issue 7/2021
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04635-2

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Springer Medicine

Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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