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European Archives of Psychiatry and Clinical Neuroscience

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28-05-2022 | SARS-CoV-2 | Original Paper

Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study

Authors: Rodolfo Furlan Damiano, Deusdedit Brandão Neto, João Vitor Ribeiro Oliveira, Jonatas Magalhães Santos, Julia Vallin Rodrigues Alves, Bruno F. Guedes, Ricardo Nitrini, Adriana Ladeira de Araújo, Melaine Oliveira, André R. Brunoni, Richard Louis Voegels, Ricardo Ferreira Bento, Geraldo Busatto, Euripedes Constantino Miguel, Orestes V. Forlenza, Fabio de Rezende Pinna, HCFMUSP COVID-19 study group

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 2/2023

Abstract

Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study assessing adult patients hospitalized due to moderate or severe forms of COVID-19 between March and August 2020. Baseline information includes several clinical and hospitalization data. Further evaluations were made using several different reliable instruments designed to assess taste and smell functions, parosmia, and neuropsychiatric disorders (using standardized psychiatric and cognitive measures). Out of 1800 eligible individuals, 701 volunteers were assessed on this study. After multivariate analysis, patients reporting parosmia had a worse perception of memory performance (p < 0.001). Moderate/severe hypogeusia was significantly associated with a worse performance on the word list memory task (p = 0.012); Concomitant moderate/severe olfactory and gustatory loss during the acute phase of COVID-19 was also significantly associated with episodic memory impairment (p = 0.006). We found a positive association between reported chemosensory (taste and olfaction) abnormalities and cognition dysfunction in post-COVID-19 patients. These findings may help us identify potential mechanisms linking these two neurobiological functions, and also support the speculation on a possible route through which SARS-CoV-2 may reach the central nervous system.

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Title: Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study
Authors: Rodolfo Furlan Damiano
Deusdedit Brandão Neto
João Vitor Ribeiro Oliveira
Jonatas Magalhães Santos
Julia Vallin Rodrigues Alves
Bruno F. Guedes
Ricardo Nitrini
Adriana Ladeira de Araújo
Melaine Oliveira
André R. Brunoni
Richard Louis Voegels
Ricardo Ferreira Bento
Geraldo Busatto
Euripedes Constantino Miguel
Orestes V. Forlenza
Fabio de Rezende Pinna
HCFMUSP COVID-19 study group
Publication date: 28-05-2022
Publisher: Springer Berlin Heidelberg
Keywords: SARS-CoV-2
COVID-19
Post-COVID Syndrome
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 2/2023
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-022-01427-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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