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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 2/2022

01-02-2022 | Tinnitus | Otology

Recurrent vestibulopathy: are cVEMP, oVEMP and inner ear MRI useful to distinguish patients with Menière’s disease and vestibular migraine?

Authors: Michael Eliezer, Michel Toupet, Juliette Housset, Emmanuel Houdart, Charlotte Hautefort

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2022

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Abstract

Purpose

The aim of this study was to assess the rate of endolymphatic hydrops (EH) on MRI and the rate of otolithic dysfunction with cVEMP and oVEMP, in patients with recurrent vertigo such as Menière’s disease (MD), vestibular migraine (VM) and vestibular Menière’s disease (vMD).

Methods

In this retrospective study, we performed 3D-FLAIR sequences with delayed acquisition in 20 MD, 20 VM and 20 vMD patients. Each subject was then assessed for the presence of EH on MRI. All patients underwent pure-tone audiometry, cVEMP and oVEMP.

Results

In MD patients, EH was observed in 18 (90%) out of 20 patients while EH was observed in only 1 MV (5%) and 1 vMD (5%) patients. We found significant differences between groups for the presence of EH on MRI (p = 0.001). MD patients had significant higher PTA level (p < 0.001) and oVEMP impairment than MV and vMD (p = 0.08 and p = 0.06, respectively). However, no significant differences were observed for cVEMP impairment, either asymmetric ratio (p = 0.36) and 1000/500 ratio (p = 0.20).

Conclusions

Concerning cVEMP, we observed no significant differences between VM, vMD and MD. However, we observed higher oVEMP impairment, PTA level and EH on MRI in MD patients. We believe that MRI could be used to differentiate MD from VM patients with cochlear symptoms. However, in cases of migraine associated with recurrent vertigo and without cochlear symptoms, we believe that MRI is not a useful tool to differentiate between VM and vMD.
Literature
1.
2.
Lempert T, Olesen J, Furman J et al (2012) Vestibular migraine: diagnostic criteria. J Vestib Res 22:167–172CrossRef
3.
Kayan A, Hood JD (1984) Neuro-otological manifestations of migraine. Brain 107(Pt 4):1123–1142CrossRef
4.
Battista RA (2004) Audiometric findings of patients with migraine-associated dizziness. Otol Neurotol 25:987–992CrossRef
5.
Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H (2002) Migraine and Meniere’s disease: is there a link? Neurology 59(1700–1704):10
6.
Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T (2012) Vestibular migraine: long-term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology 79:1607–1614CrossRef
7.
Neuhauser H, Leopold M, Von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo, and migrainous vertigo. Neurology 27;56(4):436–441.
8.
Nakada T, Yoshida T, Suga K, et al. Endolymphatic space size in patients with vestibular migraine and Ménière’s disease. J Neurol 2014
9.
Makowiec KF, Piker EG, Jacobson GP, Ramadan NM, Roberts RA (2018) Ocular and cervical vestibular evoked myogenic potentials in patients with vestibular migraine. Otol Neurotol 39:561–567CrossRef
10.
11.
Salviz M, yuce T, Acar H, Taylan I, Yuceant GA, Karatas A (2015) Diagnostic value of vestibular-evoked myogenic potentials in Ménière’s disease and vestibular migraine. J Vest Res 261–266
12.
Bolding MI, Ljostad U, Mygland A, Monstad P (2011) Vestibular sensitivity in vestibular migraine: VEMPs and motion sickness susceptibility. Cephalalgia 31:1211–1219CrossRef
13.
Baier B, Stieber N, Dieterich M (2009) Vestibular evoked myogenic potentials in vestibular migraine. J Neurol 256:1447–1454CrossRef
14.
Koo J, Balaban C (2006) Serotonin-induced plasma extravasation in the murine inner ear: possible mechanism of migraine-associated inner ear dysfunction. Cephalalgia 26:1310–1319CrossRef
15.
Zuniga M, Janky K, Schubert M, Carey J (2012) Can vestibular evoked myogenic potentials help differentiate Meniere disease from vestibular migraine? Oto Neurootol 146:788–796
16.
Zaleski A, Bogle J, Starling A, et al (2015) Vestibular evoked myogenic potentials in patients with vestibular migraines. Oto Neurootol 36:295–302 (15)
17.
Liao L, Young Y (2004) Vestibular evoked myogenic potentials in basilar artery migraine. Laryngoscope 114:1305–1309CrossRef
18.
Kim C, Jang M, Choi H, Sohn J (2015) Subclinical vestibular dysfunction in migraine patients: a preliminary study of ocular and rectified cervical vestibular evoked myogenic potentials. J Headache Pain 16:93CrossRef
19.
Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandala M et al (2015) Diagnostic criteria for Menière’s disease. J Vest Res 25(1):1–7CrossRef
20.
Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière’s disease (1995) American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol-Head Neck Surg 113(3):181–185
21.
Eliezer M, Poillon G, Gillibert A, Horion J, Cruypeninck Y, Gerardin E et al (2018) Comparison of enhancement of the vestibular perilymph between gadoterate meglumine and gadobutrol at 3-Tesla in Meniere’s disease. Diagn Interv Imaging 99(5):271–277CrossRef
22.
Kahn L, Hautefort C, Guichard JP, et al. Relationship between VHIT, cVEMP and oVEMP and compartemental MRI classification in Menière’s disease. Laryngoscope 2019
23.
Egami N, Ushio M, Yamasoba T, Yamaguchi T, Murofushi T, Iwasaki S (2013) The diagnostic value of vestibular evokeg myogenic potentials in patients with Meniere’s disease. J Vest Res 23:249–257CrossRef
24.
25.
26.
Rubin F, Simon F, Verillaud B, Herman P, Kania R, Hautefort C (2018) Comparison of video head impulse test and caloric reflex test in advanced unilateral definite Menière’s disease. Eur Ann Otorhinolaryngol Head Neck Dis 135(3):167–169CrossRef
27.
Dietrich M, Obermann M, Celebisoy N (2016) Vestibular migraine: the most frequent entity of episodic vertigo. J Neurol 263:82–89CrossRef
28.
Colebatch J, Halmagyi G, Skuse N (1994) Myogenic potentials generated by a click-evoked vestibulo-collic reflex. J Neurol Neurosurg Psychiatry 57:190–7 (10)
29.
Manzari L, Burgess A, Curthoys I (2010) Effect of bone-conducted vibration of the midline forehead (Fz) in unilateral vestibular loss (uVL): Evidence for a new indicator of unilateral otolithic function. Acta Otorhinolaryngol Ital 30:175PubMedPubMedCentral
30.
Taylor RL, Zagami AS, Gibson WP, Black DA, Wat-son SR, Halmagyi MG et al (2012) Vestibular evoked myogenic poten- tials to sound and vibration: Characteristics in vestibular mi- graine that enable seperation from Meniere’s disease. Cepha-lalgia 32(2012):213–225CrossRef
31.
Kandemir A, Celebisoy N, Kose T (2013) Cervical vestibular evoked myogenic potentials in primary headache disorders. Clin Neurophys 124:779–784CrossRef
32.
33.
Rauch SD, Zhou G, Kujawa SG, Guinan JJ, Her-rmann BS (2004) Vestibular evoked myogenic potentials show altered tuning in patients with Meniere’s disease. Otol Neurotol 25:333–338CrossRef
34.
Ramadan NM (2003) The link between glutamate and migraine. CNS Spectr 8:446–449CrossRef
35.
Edvinsson L (2017) The trigeminovascular pathway: role of CGRP and CGRP receptors in migraine. Headache 57:47–55CrossRef
36.
Olesen J (2008) The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther 120:157–171CrossRef
37.
Lee C, Jones TA (2017) Neuropharmacological targets for drug action in vestibular sensory pathways. Audiol Otol 21:125–32 (33)
38.
Popper P, Ishiyama A, Lopez I, Wackym PA (2002) Calcitonin gene-related Peptide and choline acetyltransferase colocalization in the human vestibular periphery. Audiol Neurootol 7(298–302):34
39.
Cutrer FM, Sorensen AG, Weisskoff RM et al (1998) Perfusion- weighted imaging defects during spontaneous migrainous aura. Ann Neurol 43:25–31CrossRef
40.
41.
Van der Lubbe MF, Vaidyanathan A, Van Rompaey V, Postma AA, Bruintjes TD, Kimenai DM et al (2020) The “hype” of hydrops in classifying vestibular disorders:a narrative review. J Neurol 267:197–211CrossRef
42.
Gürkov R, Kantner C, Strupp M, Flatz W, Krause E, Ertl-Wagner B (2014) Endolymphatic hydrops in patients with vestibular migraine and auditory symptoms. Eur Arch Otorhinolaryngol 271:2661–2667CrossRef
43.
44.
45.
Attyé A, Eliezer M, Medici M, Tropres I, Dumas G, Krainik A et al (2018) In vivo imaging of saccular hydrops in humans reflects sensorineural hearing loss rather than Meniere’s disease symptoms. Eur Radiol 28(7):2916–2922CrossRef
46.
Attyé A, Eliezer M, Boudiaf N, Tropres I, Chechin D, Schmerber S et al (2017) MRI of endolymphatic hydrops in patients with Meniere’s disease: a case-controlled study with a simplified classification based on saccular morphology. Eur Radiol 27:3138–3146CrossRef
47.
Nakashima T, Naganawa S, Pyykko I, Gibson WP, Sone M, Nakata S et al (2009) Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Oto-Laryngol Suppl 560:5–8CrossRef
48.
Obeidat FS, Bell SL (2019) Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease. Int J Audiol 58(11):738–746CrossRef
49.
Martines F, Dispenza F, Montalbano C, Priola R, Torrente A, La Gumina R et al (2020) Comparison of electrocochleography and video head impulse test findings in vestibular migraine and Ménière disease: a preliminary study. J Int Adv Otol 16(2):183–189CrossRef
Metadata
Title
Recurrent vestibulopathy: are cVEMP, oVEMP and inner ear MRI useful to distinguish patients with Menière’s disease and vestibular migraine?
Authors
Michael Eliezer
Michel Toupet
Juliette Housset
Emmanuel Houdart
Charlotte Hautefort
Publication date
01-02-2022
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 2/2022
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-021-06716-6

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