Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 8/2017

01-08-2017 | Head and Neck

MRI of endolymphatic hydrops in patients with Meniere’s disease: a case-controlled study with a simplified classification based on saccular morphology

Authors: Arnaud Attyé, Michael Eliezer, Naïla Boudiaf, Irène Tropres, David Chechin, Sébastien Schmerber, Georges Dumas, Alexandre Krainik

Published in: European Radiology | Issue 8/2017

Login to get access

Abstract

Objectives

Endolymphatic hydrops (EH) can be studied in patients by MRI. With the semi-quantitative grading system, previous imaging studies showed discrepancies in the occurrence and grading of EH in patients with Meniere’s disease (MD). Here, we compared the inversion of the saccule to utricle area ratio (SURI) with the semi-quantitative method of grading conventionally used to diagnose MD.

Methods

Imaging was carried out on a 3-T MRI scanner. We performed 3D-FLAIR sequences 4 h after a single intravenous dose of contrast agent. Two radiologists independently studied the morphology of the inner ear structures in the healthy subjects and MD patients. Each subject was then graded on the basis of the EH semi-quantitative analysis and on saccular morphology using axial and sagittal reference slices in the vestibule plane.

Results

Thirty healthy subjects and 30 MD patients had MRI scans. Using the semi-quantitative method, we found no significant difference in the number of subjects with EH between the two groups. SURI was found in 15 out of 30 MD patients and in none of the 30 healthy subjects. In three MD patients the saccule was not visible.

Conclusion

SURI is currently the most specific criterion for imaging diagnosis of MD.

Key points

• Half of MD patients presented with inversion of the saccule to utricle ratio.
• Saccular analysis is crucial when assessing patients with Meniere’s disease.
• In some patients, the saccule is not visible, suggestive of intra-labyrinthine fistulae.
Literature
1.
Salt AN, Plontke SK (2010) Endolymphatic hydrops: pathophysiology and experimental models. Otolaryngol Clin N Am 43:971–983CrossRef
2.
Pender DJ (2014) Endolymphatic hydrops and Ménière’s disease: a lesion meta-analysis. J Laryngol Otol 128:859–865CrossRefPubMed
3.
Nakashima T, Naganawa S, Pyykko I et al (2009) Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol Suppl 560:5–8CrossRef
4.
Hornibrook J, Flook E, Greig S et al (2015) MRI inner ear imaging and tone burst electrocochleography in the diagnosis of Ménière’s disease. Otol Neurotol 36:1109–1114CrossRefPubMedPubMedCentral
5.
Baráth K, Schuknecht B, Monge Naldi A et al (2014) Detection and grading of endolymphatic hydrops in Meniere disease using MR imaging. AJNR Am J Neuroradiol. doi:10.​3174/​ajnr.​A3856 PubMed
6.
7.
Naganawa S, Yamazaki M, Kawai H et al (2012) Visualization of endolymphatic hydrops in Ménière’s disease after single-dose intravenous gadolinium-based contrast medium: timing of optimal enhancement. Magn Reson Med Sci 11:43–51CrossRefPubMed
8.
Morita N, Kariya S, Farajzadeh Deroee A et al (2009) Membranous labyrinth volumes in normal ears and Ménière disease: a three-dimensional reconstruction study. Laryngoscope 119:2216–2220CrossRefPubMedPubMedCentral
9.
Attyé A, Dumas G, Troprès I et al (2015) Recurrent peripheral vestibulopathy: is MRI useful for the diagnosis of endolymphatic hydrops in clinical practice? Eur Radiol. doi:10.​1007/​s00330-015-3712-5
10.
Gürkov R, Berman A, Dietrich O et al (2015) MR volumetric assessment of endolymphatic hydrops. Eur Radiol 25:585–595CrossRefPubMed
11.
Liu F, Huang W, Wang Z et al (2011) Noninvasive evaluation of endolymphatic space in healthy volunteers using magnetic resonance imaging. Acta Otolaryngol 131:247–257CrossRefPubMed
12.
Liu F, Huang W, Meng X et al (2012) Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere’s disease and endolymphatic space in healthy volunteers using magnetic resonance imaging. Acta Otolaryngol 132:234–240CrossRefPubMed
13.
American Academy of Otolaryngology-Head and Neck Foundation (1995) Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière’s disease. Otolaryngol Head Neck Surg 113:181–185CrossRef
14.
Merchant S, Nadol J (eds) (2010) Schuknecht’s pathology of the ear, 3rd edn. McGraw-Hill Education (UK), London, ISBN 978 1 60795 030 1
15.
Lane JI, Witte RJ, Bolster B et al (2008) State of the art: 3T imaging of the membranous labyrinth. AJNR Am J Neuroradiol 29:1436–1440CrossRefPubMed
16.
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174CrossRefPubMed
17.
Hallpike CS, Cairns H (1938) Observations on the pathology of Ménière’s syndrome: (section of otology). Proc R Soc Med 31:1317–1336PubMedPubMedCentral
18.
Foster CA, Breeze RE (2013) Endolymphatic hydrops in Ménière’s disease: cause, consequence, or epiphenomenon? Otol Neurotol 34:1210–1214CrossRefPubMed
19.
Kimura RS, Schuknecht HF (1975) Effect of fistulae on endolymphatic hydrops. Ann Otol Rhinol Laryngol 84:271–286CrossRefPubMed
20.
Schuknecht HF, Rüther A (1991) Blockage of longitudinal flow in endolymphatic hydrops. Eur Arch Otorhinolaryngol 248:209–217CrossRefPubMed
21.
Rauch SD, Merchant SN, Thedinger BA (1989) Meniere’s syndrome and endolymphatic hydrops. Double-blind temporal bone study. Ann Otol Rhinol Laryngol 98:873–883CrossRefPubMed
22.
Horner KC (1993) Review: morphological changes associated with endolymphatic hydrops. Scanning Microsc 7:223–238PubMed
23.
24.
de Waele C, Tran Ba Huy P, Diard JP et al (1999) Saccular dysfunction in Ménière’s patients. A vestibular-evoked myogenic potential study. Ann N Y Acad Sci 871:392–397CrossRefPubMed
25.
26.
Lin M-Y, Timmer FCA, Oriel BS et al (2006) Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope 116:987–992CrossRefPubMedPubMedCentral
27.
Naganawa S, Yamazaki M, Kawai H et al (2012) Imaging of Ménière’s disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time. Magn Reson Med Sci 11:213–219CrossRefPubMed
28.
Bykowski J, Harris JP, Miller M et al (2015) Intratympanic contrast in the evaluation of Menière disease: understanding the limits. AJNR Am J Neuroradiol 36:1326–1332CrossRefPubMed
29.
Nakashima T, Naganawa S, Sugiura M et al (2007) Visualization of endolymphatic hydrops in patients with Meniere’s disease. Laryngoscope 117:415–420CrossRefPubMed
30.
Naganawa S, Sone M (2014) 3D real inversion recovery MR imaging for the visualization of endolymphatic hydrops. AJNR Am J Neuroradiol. doi:10.​3174/​ajnr.​A4126
31.
Sepahdari AR, Vorasubin N, Ishiyama G, Ishiyama A (2016) Endolymphatic hydrops reversal following acetazolamide therapy: demonstration with delayed intravenous contrast-enhanced 3D-FLAIR MRI. AJNR Am J Neuroradiol 37:151–154CrossRefPubMed
32.
Naganawa S, Yamazaki M, Kawai H et al (2010) Visualization of endolymphatic hydrops in Ménière’s disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR. Magn Reson Med Sci 9:237–242CrossRefPubMed
Metadata
Title
MRI of endolymphatic hydrops in patients with Meniere’s disease: a case-controlled study with a simplified classification based on saccular morphology
Authors
Arnaud Attyé
Michael Eliezer
Naïla Boudiaf
Irène Tropres
David Chechin
Sébastien Schmerber
Georges Dumas
Alexandre Krainik
Publication date
01-08-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4701-z

Other articles of this Issue 8/2017

European Radiology 8/2017 Go to the issue

Magnetic Resonance

Cyclops lesions detected by MRI are frequent findings after ACL surgical reconstruction but do not impact clinical outcome over 2 years

Chest

Comparison of the effects of model-based iterative reconstruction and filtered back projection algorithms on software measurements in pulmonary subsolid nodules

Musculoskeletal

Diagnostic accuracy of contemporary multidetector computed tomography (MDCT) for the detection of lumbar disc herniation

Oncology

Can lymphovascular invasion be predicted by preoperative multiphasic dynamic CT in patients with advanced gastric cancer?

Neuro

Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study

Breast

Can mechanical imaging increase the specificity of mammography screening?