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Archives of Gynecology and Obstetrics

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01-05-2015 | General Gynecology

RETRACTED ARTICLE: Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome

Authors: Xiao-Hong Wang, Jun-Qing Wang, Yan Xu, Li-Ping Huang

Published in: Archives of Gynecology and Obstetrics | Issue 5/2015

Abstract

Objective

To compare the therapeutic effects of metformin (Met) and laparoscopic ovarian drilling (LOD) in clomiphene and insulin-resistant patients with polycystic ovary syndrome (CIRPCOS).

Methods

A total of 110 patients were randomly divided into two groups. One group was administered Met (n = 55), while the other group underwent LOD (n = 55). Rates of ovulation, pregnancy, and abortion were compared between both groups.

Results

Rates of normal menstruation, ovulation, and pregnancy in the LOD group were higher than in the Met group: 76.4 % (42/55) vs. 58.2 % (32/55), P < 0.04; 50.8 % (11/258) vs. 33.5 % (94/281), P < 0.001; 38.2 % (21/55) vs. 20.0 % (11/55), P < 0.03. The difference in the early abortion rate between both groups was not statistically significant.

Conclusions

Although Met can significantly improve a patient’s insulin resistance, we found that in patients diagnosed with CIRCPOS, LOD can be much more effective in improving rates of normal menstruation, ovulation, and pregnancy.

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Title: RETRACTED ARTICLE: Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome
Authors: Xiao-Hong Wang
Jun-Qing Wang
Yan Xu
Li-Ping Huang
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3486-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

RETRACTED ARTICLE: Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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