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01-05-2015 | Maternal-Fetal Medicine

Is there an association between liver type fatty acid binding protein and severity of preeclampsia?

Authors: Ozlem Uzunlar, Yaprak Engin-Ustun, Sebnem Ozyer, Nuri Danısman, Tuba Candar, Senem M. Keskin, Leyla Mollamahmutoglu

Published in: Archives of Gynecology and Obstetrics | Issue 5/2015

Abstract

Objective

The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia.

Method

A case–control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild–moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood samples were obtained during an antenatal clinic visit in normal pregnant women, and at the time of diagnosis in women with preeclampsia. Serum LFABP levels were measured by the quantitative sandwich enzyme immunoassay technique.

Results

Serum LFABP level was significantly higher in severe and mild–moderate preeclampsia groups than normal pregnancy group (1,709.90 ± 94.82, 1,614.93 ± 118.22, and 1,532.36 ± 140.98 pg/ml, respectively; p < 0.001). In multivariate analysis, the severity of preeclampsia was correlated with LFABP level [unadjusted odds ratio (95 % confidence interval), 1.008 (1.003–1.012), p < 0.001 and LDH 1.063 (1.029–1.099), p < 0.001].

Conclusion

Maternal serum LFABP level appears to be correlated with the severity of the preeclampsia and can be used to confirm the diagnosis.

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Title: Is there an association between liver type fatty acid binding protein and severity of preeclampsia?
Authors: Ozlem Uzunlar
Yaprak Engin-Ustun
Sebnem Ozyer
Nuri Danısman
Tuba Candar
Senem M. Keskin
Leyla Mollamahmutoglu
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3540-x

At a glance: The STEP trials

Springer Medicine

Is there an association between liver type fatty acid binding protein and severity of preeclampsia?

Abstract

Objective

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

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