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Open Access 01-07-2012 | Review

Emerging beneficial roles of sirtuins in heart failure

Authors: Masaya Tanno, Atsushi Kuno, Yoshiyuki Horio, Tetsuji Miura

Published in: Basic Research in Cardiology | Issue 4/2012

Abstract

Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, seven sirtuins (SIRT1–7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and mitochondria, respectively. They participate in biological functions related to development of heart failure, including regulation of energy production, oxidative stress, intracellular signaling, angiogenesis, autophagy and cell death/survival. Emerging evidence indicates that the two sirtuins play protective roles in failing hearts. Here, we summarize current knowledge of sirtuin functions in the heart and discuss its translation into therapy for heart failure.

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Title: Emerging beneficial roles of sirtuins in heart failure
Authors: Masaya Tanno
Atsushi Kuno
Yoshiyuki Horio
Tetsuji Miura
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Basic Research in Cardiology / Issue 4/2012
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-012-0273-5

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Emerging beneficial roles of sirtuins in heart failure

Abstract

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Abstract

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