Published in:
01-06-2017 | Interventional
Ethanolgel sclerotherapy of venous malformations improves health-related quality-of-life in adults and children – results of a prospective study
Authors:
Walter A. Wohlgemuth, Rene Müller-Wille, Veronika Teusch, Simone Hammer, Moritz Wildgruber, Wibke Uller
Published in:
European Radiology
|
Issue 6/2017
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Abstract
Objectives
To assess the treatment-induced changes of health-related quality-of-life (HRQoL) in patients with venous malformations (VM) who underwent ethanol gel sclerotherapy.
Methods
The prospective study in children and adults was approved by the local ethics committee. 31 patients (mean age 23.42 years, range 6.6 – 46.5; 26 female, 5 male) with VM were included. Patients’ self-assessed HRQoL was measured before and after treatment using psychometrically validated questionnaires for adults and children. Differences were analysed with a paired t test.
Results
58 sclerotherapy sessions were performed. The Physical Component Summary (PCS) at baseline was 43.69 and increased significantly (p = 0.01122) to 48.95 after treatment. The bodily pain (BP) scale increased significantly from 37.94 to 48.56 (p = 0.00002), the general health (GH) scale increased significantly from 46.69 to 52.17 (p = 0.00609). Baseline Physical Summary Score (PHS) in children increased significantly after treatment (p < 0.00001) from 25.25 to 45.89. The baseline Psychosocial Summary Score (PSS) in children was 51.08 and increased significantly (p = 0.00031) after treatment to 58.84.
Conclusion
Paediatric and adult patients with VM suffer from bodily pain with overall reduced physical functioning. After sclerotherapy, these restrictions are successfully returning to normal levels with a positive effect on mental and psychosocial domains.
Key points
• Sclerotherapy in venous malformation patients has an unknown effect on health-related quality-of-life
• Prospective study showed improvements in bodily pain and general health in adults
• Children and adults improved from treatment with ethanol gel
• Sclerotherapy is an appropriate therapy