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European Radiology

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01-06-2017 | Magnetic Resonance

Prognostic significance of focal lesions and diffuse infiltration on MRI for multiple myeloma: a meta-analysis

Authors: So-Yeon Lee, Hyun-Jung Kim, Yu Ri Shin, Hee-Jin Park, Yun-Gyoo Lee, Suk Joong Oh

Published in: European Radiology | Issue 6/2017

Abstract

Objectives

MRI of bone marrow of the axial skeleton is recommended for evaluation of multiple myeloma. The impact of bone marrow involvement pattern on MRI for determining progression-free survival (PFS) and overall survival (OS) is not yet clear.

Methods

We performed a meta-analysis of research on the prognostic significance of MRI patterns for OS and PFS using a random effects model. Databases searched without language restriction were MEDLINE, EMBASE, and the Cochrane Library (January 1976 to April 2014). Manual searches were also conducted.

Results

Of 10,953 citations identified in the original search, 10 cohort studies for a total of 2015 patients met the inclusion criteria. Nine of the 10 included studies are from three research groups. Pooled hazard ratios were 1.80 (95 % confidence interval [CI] 1.32–2.46; P < 0.001) for OS and 2.30 (95 % CI 1.65–3.20; P < 0.001) for PFS for focal lesions on MRI; and 1.70 (95 % CI 1.30–2.21; P < 0.001) for OS and 1.74 (95 % CI 1.07–2.85; P = 0.03) for PFS for diffuse infiltration on MRI. No significant heterogeneity was observed among studies.

Conclusions

This meta-analysis demonstrated an association between focal lesions and diffuse infiltration and poor prognosis in this population.

Key Points

• MRI findings of multiple myeloma include normal, focal, variegated and diffuse infiltration

• Focal lesions and diffuse infiltration on MRI were poor prognostic factors

• Bone marrow involvement pattern on MRI can help physicians assess prognosis

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Title: Prognostic significance of focal lesions and diffuse infiltration on MRI for multiple myeloma: a meta-analysis
Authors: So-Yeon Lee
Hyun-Jung Kim
Yu Ri Shin
Hee-Jin Park
Yun-Gyoo Lee
Suk Joong Oh
Publication date: 01-06-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4543-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic significance of focal lesions and diffuse infiltration on MRI for multiple myeloma: a meta-analysis

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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