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01-04-2016 | Hepatobiliary-Pancreas

Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry

Authors: Michael Haimerl, Mona Schlabeck, Niklas Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp Wiggermann

Published in: European Radiology | Issue 4/2016

Abstract

Objectives

To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) relaxometry with gadoxetic acid (Gd-EOB-DTPA).

Methods

One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDR_est).

Results

Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1_post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDR_est.

Conclusions

Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR relaxometry. Volume-assisted MR relaxometry has a stronger correlation with liver function than does MR relaxometry.

Key Points

• Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function.

• Volume-assisted Gd-EOB-DTPA–enhanced MR relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR relaxometry.

• Gd-EOB-DTPA–enhanced MR relaxometry may provide robust parameters for detecting and characterizing liver disease.

• Gd-EOB-DTPA–enhanced MR relaxometry may be useful for monitoring liver disease progression.

• Gd-EOB-DTPA–enhanced MR relaxometry has the potential to become a novel liver function index.

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Title: Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry
Authors: Michael Haimerl
Mona Schlabeck
Niklas Verloh
Florian Zeman
Claudia Fellner
Dominik Nickel
Ana Paula Barreiros
Martin Loss
Christian Stroszczynski
Philipp Wiggermann
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3919-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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