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European Radiology
Published in: European Radiology 4/2014

01-04-2014 | Magnetic Resonance

Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function

Authors: Tomohide Yoneyama, Yoshihiko Fukukura, Kiyohisa Kamimura, Koji Takumi, Aya Umanodan, Shinichi Ueno, Masayuki Nakajo

Published in: European Radiology | Issue 4/2014

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Abstract

Objective

We aimed to develop and assess the efficacy of a liver function index that combines liver enhancement and liver volume to standard liver volume (LV/SLV) ratio on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI.

Methods

In all, 111 patients underwent a Gd-EOB-DTPA-enhanced MRI, including T1 mapping, before and 20 min after Gd-EOB-DTPA administration. We calculated the following Gd-EOB-DTPA-enhanced MRI-based liver function indices: relative enhancement of the liver, corrected enhancement of the liver-to-spleen ratio, LSC_N20, increase rate of the liver-to-muscle ratio, reduction rate of T1 relaxation time of the liver, ΔR1 of the liver and K Hep; the indices were multiplied by the LV/SLV ratio. We calculated the correlations between an indocyanine green (ICG) clearance and the Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio, by using Pearson correlation analysis.

Results

There were significant correlations between all Gd-EOB-DTPA-enhanced MRI-based liver function indices and ICG clearance (r = −0.354 to −0.574, P < 0.001). All Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio (r = −0.394 to −0.700, P < 0.001) were more strongly correlated with the ICG clearance than those without multiplication by the LV/SLV ratio.

Conclusions

Gd-EOB-DTPA-enhanced MRI-based liver function indices that combine liver enhancement and the LV/SLV ratio may more reliably estimate liver function.

Key points

• Gd-EOB-DTPA-enhanced MRI is useful for assessing liver function.
• Liver enhancement on Gd-EOB-DTPA-enhanced MRI correlates with indocyanine green (ICG) clearance.
• Liver volume to standard liver volume (LV/SLV) ratio correlates with ICG clearance.
• Liver enhancement and LV/SLV ratio help to estimate liver function.
Literature
1.
Seyama Y, Kokudo N (2009) Assessment of liver function for safe hepatic resection. Hepatol Res 39:107–116PubMedCrossRef
2.
3.
Roskams T, Desmet V, Verslype C (2006) Development, structure and function of the liver. Churchill Livingstone, Philadelphia, pp 56–61
4.
Matsumata T, Kanematsu T, Yoshida Y, Furuta T, Yanaga K, Sugimachi K (1987) The indocyanine green test enables prediction of postoperative complications after hepatic resection. World J Surg 11:678–681PubMedCrossRef
5.
Lau H, Man K, Fan ST, Yu WC, Lo CM, Wong J (1997) Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg 84:1255–1259PubMedCrossRef
6.
Ishikawa M, Yogita S, Miyake H et al (2002) Clarification of risk factors for hepatectomy in patients with hepatocellular carcinoma. Hepatogastroenterology 49:1625–1631PubMed
7.
Weinmann HJ, Schuhmann-Giampieri G, Schmitt-Willich H, Vogler H, Frenzel T, Gries H (1991) A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI. Magn Reson Med 22:233–237PubMedCrossRef
8.
Schuhmann-Giampieri G, Schmitt-Willich H, Press WR, Negishi C, Weinmann HJ, Speck U (1992) Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system. Radiology 183:59–64PubMed
9.
Hamm B, Staks T, Mühler A et al (1995) Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 195:785–792PubMed
10.
Reimer P, Rummeny EJ, Shamsi K et al (1996) Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 199:177–183PubMed
11.
Bluemke DA, Sahani D, Amendola M et al (2005) Efficacy and safety of MR imaging with liver-specific contrast agent: US multicenter phase III study. Radiology 237:89–98PubMedCrossRef
12.
Ba-Sslamah A, Uffmann M, Saini S et al (2009) Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions. Eur Radiol 19:342–357CrossRef
13.
Motosugi U, Ichikawa T, Tominaga L et al (2009) Delay before the hepatocyte phase of Gd-EOB-DTPA-enhanced MR imaging: is it possible to shorten the examination time? Eur Radiol 19:2623–2629PubMedCrossRef
14.
Kogita S, Imai Y, Okada M et al (2010) Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol 20:2405–2413PubMedCrossRef
15.
Ichikawa T, Saito K, Yoshioka N et al (2012) Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular carcinoma and chronic liver disease. Invest Radiol 45:133–141CrossRef
16.
Motosugi U, Ichikawa T, Sou H et al (2012) Distinguishing hypervascular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging. Radiology 256:151–158CrossRef
17.
Kim YK, Kim CS, Han YM, Park G (2010) Detection of small hepatocellular carcinoma: can gadoxetic acid-enhanced magnetic resonance imaging replace combining gadopentetate dimeglumine-enhanced and superparamagnetic iron oxide-enhanced magnetic resonance imaging? Invest Radiol 45:740–746PubMedCrossRef
18.
Tamada T, Ito K, Higaki A et al (2011) Gd-EOB-DTPA-enhanced MR imaging: evaluation of hepatic enhancement effects in normal and cirrhotic livers. Eur J Radiol 80:311–316CrossRef
19.
Katsube T, Okada M, Kumano S et al (2011) Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Invest Radiol 46:277–283PubMedCrossRef
20.
Saito K, Ledsam J, Sourbron S et al (2013) Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. J Magn Reson Imaging 37:1109–1114PubMedCrossRef
21.
Motosugi U, Ichikawa T, Sou H et al (2009) Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging 30:1042–1046PubMedCrossRef
22.
Utsunomiya T, Shimada M, Hanaoka J et al (2012) Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve. J Gastroenterol 47:470–476PubMedCrossRef
23.
Yamada A, Hara T, Li F et al (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 260:727–733PubMedCrossRef
24.
Motosugi U, Ichikawa T, Oguri M et al (2011) Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging: comparison with aspartate aminotransferase-to-platelet ratio index. Magn Reson Imaging 29:1047–1052PubMedCrossRef
25.
Watanabe H, Kanematsu M, Goshima S et al (2011) Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging-preliminary observations. Radiology 259:142–150PubMedCrossRef
26.
Goshima S, Kanematsu M, Watanabe H et al (2012) Gd-EOB-DTPA-enhanced MR imaging: prediction of hepatic fibrosis stages using liver contrast enhancement index and liver-to-spleen volumetric ratio. J Magn Reson Imaging 36:1148–1153PubMedCrossRef
27.
Chen BB, Hsu CY, Yu CW et al (2012) Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients. Eur Radiol 22:171–180PubMedCrossRef
28.
Kubota K, Tamura T, Aoyama N et al (2012) Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncol Lett 3:990–994PubMedCentralPubMed
29.
Norén B, Forsgren MF, Dahlqvist Leinhard O et al (2013) Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA. Eur Radiol 23:174–181PubMedCrossRef
30.
Dahlqvist Leinhard O, Dahlström N, Kihlberg J (2012) Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study. Eur Radiol 22:642–653PubMedCrossRef
31.
Nishie A, Ushijima Y, Tajima T et al (2012) Quantitative analysis of liver function using superparamagnetic iron oxide- and Gd-EOB-DTPA-enhanced MRI: comparison with technetium-99m galactosyl serum albumin scintigraphy. Eur J Radiol 81:1100–1104PubMedCrossRef
32.
Geisel D, Lüdemann L, Keuchel T (2013) Increase in left liver lobe function after preoperative right portal vein embolisation assessed with gadolinium-EOB-DTPA MRI. Eur Radiol 23:2555–2560PubMedCrossRef
33.
Zhou XP, Lu T, Wei YG et al (2007) Liver volume variation in patients with virus-induced cirrhosis: findings on MDCT. AJR Am J Roentgenol 189:W153–W159PubMedCrossRef
34.
Tong C, Xu X, Liu C, Zhang T, Qu K (2012) Assessment of liver volume variation to evaluate liver function. Front Med 6:421–427PubMedCrossRef
35.
Wang HZ, Riederer SJ, Lee JN (1987) Optimizing the precision in T1 relaxation estimation using limited flip angles. Magn Reson Med 5:399–416PubMedCrossRef
36.
Deoni SC (2007) High-resolution T1 mapping of the brain at 3 T with driven equilibrium single pulse observation of T1 with high-speed incorporation of RF field inhomogeneities (DESPOT1-HIFI). J Magn Reson Imaging 26:1106–1111PubMedCrossRef
37.
Kim KA, Park MS, Kim IS et al (2012) Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 Tesla MRI before and after oxygen inhalation. J Magn Reson Imaging 36:405–410PubMedCrossRef
38.
Yoshizumi T, Taketomi A, Kayashima H et al (2008) Estimation of standard liver volume for Japanese adults. Transplant Proc 40:1456–1460PubMedCrossRef
39.
Ozaki K, Matsui O, Kobayashi S et al (2010) Selective atrophy of the middle hepatic venous drainage area in hepatitis C-related cirrhotic liver: morphometric study by using multidetector CT. Radiology 257:705–714PubMedCrossRef
40.
Li WX, Zhao XT, Chai WM et al (2010) Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography. J Dig Dis 11:215–223PubMed
41.
42.
43.
44.
Treier R, Steingoetter A, Fried M et al (2007) Optimized and combined T1 and B1 mapping technique for fast and accurate T1 quantification in contrast-enhanced abdominal MRI. Magn Reson Med 57:568–576PubMedCrossRef
Metadata
Title
Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function
Authors
Tomohide Yoneyama
Yoshihiko Fukukura
Kiyohisa Kamimura
Koji Takumi
Aya Umanodan
Shinichi Ueno
Masayuki Nakajo
Publication date
01-04-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 4/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-3086-5

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