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Published in: European Radiology 4/2016

Open Access 01-04-2016 | Contrast Media

ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents

Authors: E. Neri, M. A. Bali, A. Ba-Ssalamah, P. Boraschi, G. Brancatelli, F. Caseiro Alves, L. Grazioli, T. Helmberger, J. M. Lee, R. Manfredi, L. Martì-Bonmatì, C. Matos, E. M. Merkle, B. Op De Beeck, W. Schima, S. Skehan, V. Vilgrain, C. Zech, C. Bartolozzi

Published in: European Radiology | Issue 4/2016

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Abstract

Objectives

To develop a consensus and provide updated recommendations on liver MR imaging and the clinical use of liver-specific contrast agents.

Methods

The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) formed a multinational European panel of experts, selected on the basis of a literature review and their leadership in the field of liver MR imaging. A modified Delphi process was adopted to draft a list of statements. Descriptive and Cronbach’s statistics were used to rate levels of agreement and internal reliability of the consensus.

Results

Three Delphi rounds were conducted and 76 statements composed on MR technique (n = 17), clinical application of liver-specific contrast agents in benign, focal liver lesions (n = 7), malignant liver lesions in non-cirrhotic (n = 9) and in cirrhotic patients (n = 18), diffuse and vascular liver diseases (n = 12), and bile ducts (n = 13). The overall mean score of agreement was 4.84 (SD ±0.17). Full consensus was reached in 22 % of all statements in all working groups, with no full consensus reached on diffuse and vascular diseases.

Conclusions

The consensus provided updated recommendations on the methodology, and clinical indications, of MRI with liver specific contrast agents in the study of liver diseases.

Key points

Liver-specific contrast agents are recommended in MRI of the liver.
The hepatobiliary phase improves the detection and characterization of hepatocellular lesions.
Liver-specific contrast agents can improve the detection of HCC.
Footnotes
1
X.X. refers to a panelist who left the panel after the third round.
 
Literature
1.
go back to reference Bellin MF, Vasile M, Morel-Precetti S (2003) Currently used non-specific extracellular MR contrast media. Eur Radiol 13:2688–2698CrossRefPubMed Bellin MF, Vasile M, Morel-Precetti S (2003) Currently used non-specific extracellular MR contrast media. Eur Radiol 13:2688–2698CrossRefPubMed
2.
go back to reference Balci NC, Semelka RC (2005) Contrast agents for MR imaging of the liver. Radiol Clin N Am 43:887–898CrossRefPubMed Balci NC, Semelka RC (2005) Contrast agents for MR imaging of the liver. Radiol Clin N Am 43:887–898CrossRefPubMed
3.
go back to reference Erturk SM, Alberich-Bayarri A, Herrmann KA, Marti-Bonmati L, Ros PR (2009) Use of 3.0-T MR imaging for evaluation of the abdomen. Radiographics 29:1547–1563CrossRefPubMed Erturk SM, Alberich-Bayarri A, Herrmann KA, Marti-Bonmati L, Ros PR (2009) Use of 3.0-T MR imaging for evaluation of the abdomen. Radiographics 29:1547–1563CrossRefPubMed
4.
5.
go back to reference Zech CJ, Bartolozzi C, Bioulac-Sage P et al (2013) Consensus report of the fifth international forum for liver MRI. AJR Am J Roentgenol 201:97–107CrossRefPubMed Zech CJ, Bartolozzi C, Bioulac-Sage P et al (2013) Consensus report of the fifth international forum for liver MRI. AJR Am J Roentgenol 201:97–107CrossRefPubMed
6.
go back to reference Choi JY, Lee JM, Sirlin CB (2014) CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects. Radiology 272:635–654, reviewer 2, comment 24CrossRefPubMedPubMedCentral Choi JY, Lee JM, Sirlin CB (2014) CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects. Radiology 272:635–654, reviewer 2, comment 24CrossRefPubMedPubMedCentral
7.
go back to reference van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE (1999) Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther 290:153–157PubMed van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE (1999) Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther 290:153–157PubMed
8.
go back to reference Seale MK, Catalano OA, Saini S, Hahn PF, Sahani DV (2009) Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics 29:1725–1748CrossRefPubMed Seale MK, Catalano OA, Saini S, Hahn PF, Sahani DV (2009) Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics 29:1725–1748CrossRefPubMed
9.
go back to reference Semelka RC, Helmberger TK (2001) Contrast agents for MR imaging of the liver. Radiology 218:27–38CrossRefPubMed Semelka RC, Helmberger TK (2001) Contrast agents for MR imaging of the liver. Radiology 218:27–38CrossRefPubMed
10.
go back to reference Ringe KI, Husarik DB, Sirlin CB, Merkle EM (2010) Gadoxetate disodium–enhanced MRI of the liver: Part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR 195:13–28CrossRefPubMed Ringe KI, Husarik DB, Sirlin CB, Merkle EM (2010) Gadoxetate disodium–enhanced MRI of the liver: Part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR 195:13–28CrossRefPubMed
11.
go back to reference Goodwin MD, Dobson JE, Sirlin CB, Lim BG, Stella DL (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents. RadioGraphics 31:1547–1568CrossRefPubMed Goodwin MD, Dobson JE, Sirlin CB, Lim BG, Stella DL (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents. RadioGraphics 31:1547–1568CrossRefPubMed
12.
go back to reference Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421–429CrossRefPubMed Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421–429CrossRefPubMed
13.
go back to reference Guglielmo FF, Mitchell DG, Gupta S (2014) Gadolinium contrast agent selection and optimal use for body MR imaging. Radiol Clin N Am 52:637–656CrossRefPubMed Guglielmo FF, Mitchell DG, Gupta S (2014) Gadolinium contrast agent selection and optimal use for body MR imaging. Radiol Clin N Am 52:637–656CrossRefPubMed
14.
go back to reference Ronot M, Vilgrain V (2014) Hepatocellular carcinoma: diagnostic criteria by imaging techniques. Best Pract Res Clin Gastroenterol 28:795–812CrossRefPubMed Ronot M, Vilgrain V (2014) Hepatocellular carcinoma: diagnostic criteria by imaging techniques. Best Pract Res Clin Gastroenterol 28:795–812CrossRefPubMed
15.
go back to reference Cogley JR, Miller FH (2014) MR imaging of benign focal liver lesions. Radiol Clin N Am 52:657–682CrossRefPubMed Cogley JR, Miller FH (2014) MR imaging of benign focal liver lesions. Radiol Clin N Am 52:657–682CrossRefPubMed
16.
go back to reference Hope TA, Ohliger MA, Qayyum A (2014) MR imaging of diffuse liver disease: from technique to diagnosis. Radiol Clin N Am 52:709–724CrossRefPubMed Hope TA, Ohliger MA, Qayyum A (2014) MR imaging of diffuse liver disease: from technique to diagnosis. Radiol Clin N Am 52:709–724CrossRefPubMed
17.
go back to reference Graham B, Regehr G, Wright JG (2003) Delphi as a method to establish consensus for diagnostic criteria. J Clin Epidemiol 56:1150–1156CrossRefPubMed Graham B, Regehr G, Wright JG (2003) Delphi as a method to establish consensus for diagnostic criteria. J Clin Epidemiol 56:1150–1156CrossRefPubMed
18.
go back to reference Guyatt G, Oxman AD, Akl EA et al (2011) GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64:383–394CrossRefPubMed Guyatt G, Oxman AD, Akl EA et al (2011) GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64:383–394CrossRefPubMed
19.
go back to reference Bravo G, Potvin L (1991) Estimating the reliability of continuous measures with Cronbach's alpha or the intraclass correlation coefficient: toward the integration of two traditions. J Clin Epidemiol 44:381–390CrossRefPubMed Bravo G, Potvin L (1991) Estimating the reliability of continuous measures with Cronbach's alpha or the intraclass correlation coefficient: toward the integration of two traditions. J Clin Epidemiol 44:381–390CrossRefPubMed
20.
go back to reference Cronbach L (1951) Coefficient alpha and the internal structure of tests. Psychometrika 16:3CrossRef Cronbach L (1951) Coefficient alpha and the internal structure of tests. Psychometrika 16:3CrossRef
21.
go back to reference Ramalho M, Altun E, Herédia V, Zapparoli M, Semelka R (2007) Liver MR imaging: 1.5T versus 3T. Magn Reson Imaging Clin N Am 15:321–347CrossRefPubMed Ramalho M, Altun E, Herédia V, Zapparoli M, Semelka R (2007) Liver MR imaging: 1.5T versus 3T. Magn Reson Imaging Clin N Am 15:321–347CrossRefPubMed
22.
go back to reference Merkle EM, Dale BM, Paulson EK (2006) Abdominal MR imaging at 3T. Magn Reson Imaging Clin N Am 14:17–26CrossRefPubMed Merkle EM, Dale BM, Paulson EK (2006) Abdominal MR imaging at 3T. Magn Reson Imaging Clin N Am 14:17–26CrossRefPubMed
23.
go back to reference von Falkenhausen MM, Lutterbey G, Morakkabati-Spitz N et al (2006) High-field-strength MR imaging of the liver at 3.0 T: intraindividual comparative study with MR imaging at 1.5 T. Radiology 241:156–166 (reviewer 2, comment 15)CrossRef von Falkenhausen MM, Lutterbey G, Morakkabati-Spitz N et al (2006) High-field-strength MR imaging of the liver at 3.0 T: intraindividual comparative study with MR imaging at 1.5 T. Radiology 241:156–166 (reviewer 2, comment 15)CrossRef
24.
go back to reference Chang JM, Lee JM, Lee MW et al (2006) Superparamagnetic iron oxide-enhanced liver magnetic resonance imaging: comparison of 1.5 T and 3.0 T imaging for detection of focal malignant liver lesions. Investig Radiol 41:168–174 (reviewer 2, comment 15)CrossRef Chang JM, Lee JM, Lee MW et al (2006) Superparamagnetic iron oxide-enhanced liver magnetic resonance imaging: comparison of 1.5 T and 3.0 T imaging for detection of focal malignant liver lesions. Investig Radiol 41:168–174 (reviewer 2, comment 15)CrossRef
25.
go back to reference Gupta RT, Iseman CM, Leyendecker JR, Shyknevsky I, Merkle EM, Taouli B (2012) Diagnosis of focal nodular hyperplasia with MRI: multicenter retrospective study comparing gadobenate dimeglumine to gadoxetate disodium. AJR Am J Roentgenol 199:35–43 (reviewer 4, comment 2)CrossRefPubMed Gupta RT, Iseman CM, Leyendecker JR, Shyknevsky I, Merkle EM, Taouli B (2012) Diagnosis of focal nodular hyperplasia with MRI: multicenter retrospective study comparing gadobenate dimeglumine to gadoxetate disodium. AJR Am J Roentgenol 199:35–43 (reviewer 4, comment 2)CrossRefPubMed
26.
go back to reference Karam AR, Shankar S, Surapaneni P, Kim YH, Hussain S (2010) Focal nodular hyperplasia: central scar enhancement pattern using gadoxetate disodium. J Magn Reson Imaging 32:341–344 (reviewer 4, comment 2)CrossRefPubMed Karam AR, Shankar S, Surapaneni P, Kim YH, Hussain S (2010) Focal nodular hyperplasia: central scar enhancement pattern using gadoxetate disodium. J Magn Reson Imaging 32:341–344 (reviewer 4, comment 2)CrossRefPubMed
27.
go back to reference Park Y, Kim SH, Kim SH et al (2010) Gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI versus gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI for preoperatively detecting hepatocellular carcinoma: an initial experience. Korean J Radiol 11:433–440 (reviewer 4, comment 2)CrossRefPubMedPubMedCentral Park Y, Kim SH, Kim SH et al (2010) Gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI versus gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI for preoperatively detecting hepatocellular carcinoma: an initial experience. Korean J Radiol 11:433–440 (reviewer 4, comment 2)CrossRefPubMedPubMedCentral
28.
go back to reference Jeong WK, Kim YK, Song KD, Choi D, Lim HK (2013) The MR imaging diagnosis of liver diseases using gadoxetic acid: emphasis on hepatobiliary phase. Clin Mol Hepatol 19:360–366 (reviewer 2, comment 24)CrossRefPubMedPubMedCentral Jeong WK, Kim YK, Song KD, Choi D, Lim HK (2013) The MR imaging diagnosis of liver diseases using gadoxetic acid: emphasis on hepatobiliary phase. Clin Mol Hepatol 19:360–366 (reviewer 2, comment 24)CrossRefPubMedPubMedCentral
29.
go back to reference Kim HJ, Kim BS, Kim MJ et al (2013) Enhancement of the liver and pancreas in the hepatic arterial dominant phase: comparison of hepatocyte-specific MRI contrast agents, gadoxetic acid and gadobenate. Reson Imaging 37:903–938 (reviewer 2, comment 24)CrossRef Kim HJ, Kim BS, Kim MJ et al (2013) Enhancement of the liver and pancreas in the hepatic arterial dominant phase: comparison of hepatocyte-specific MRI contrast agents, gadoxetic acid and gadobenate. Reson Imaging 37:903–938 (reviewer 2, comment 24)CrossRef
30.
go back to reference Ba-Ssalamah A, Qayyum A, Bastati N, Fakhrai N, Herold CJ, Caseiro Alves F (2014) P4 radiology of hepatobiliary diseases with gadoxetic acid-enhanced MRI as a biomarker. Expert Rev Gastroenterol Hepatol 8:147–160CrossRefPubMed Ba-Ssalamah A, Qayyum A, Bastati N, Fakhrai N, Herold CJ, Caseiro Alves F (2014) P4 radiology of hepatobiliary diseases with gadoxetic acid-enhanced MRI as a biomarker. Expert Rev Gastroenterol Hepatol 8:147–160CrossRefPubMed
31.
go back to reference Grazioli L, Bondioni MP, Haradome H et al (2012) Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 262:520–529CrossRefPubMed Grazioli L, Bondioni MP, Haradome H et al (2012) Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 262:520–529CrossRefPubMed
32.
go back to reference Grazioli L, Morana G, Kirchin MA, Schneider G (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenatedimeglumine-enhanced MR imaging: prospective study. Radiology 236:166–177 (reviewer 4, comment 4)CrossRefPubMed Grazioli L, Morana G, Kirchin MA, Schneider G (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenatedimeglumine-enhanced MR imaging: prospective study. Radiology 236:166–177 (reviewer 4, comment 4)CrossRefPubMed
33.
go back to reference Haimerl M, Wächtler M, Platzek I et al (2013) Added value of Gd-EOB-DTPA-enhanced Hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions. BMC Med Imaging 13:41 (reviewer 2, comment 24)CrossRefPubMedPubMedCentral Haimerl M, Wächtler M, Platzek I et al (2013) Added value of Gd-EOB-DTPA-enhanced Hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions. BMC Med Imaging 13:41 (reviewer 2, comment 24)CrossRefPubMedPubMedCentral
34.
go back to reference Morana G, Grazioli L, Kirchin MA et al (2011) Solid hypervascular liver lesions: accurate identification of true benign lesions on enhanced dynamic and hepatobiliary phase magnetic resonance imaging after gadobenatedimeglumine administration. Investig Radiol 46:225–239 (reviewer 4, comment 5)CrossRef Morana G, Grazioli L, Kirchin MA et al (2011) Solid hypervascular liver lesions: accurate identification of true benign lesions on enhanced dynamic and hepatobiliary phase magnetic resonance imaging after gadobenatedimeglumine administration. Investig Radiol 46:225–239 (reviewer 4, comment 5)CrossRef
35.
go back to reference Scharitzer M, Ba-Ssalamah A, Ringl H, Kölblinger C, Grünberger T, Weber M, Schima W (2013) Preoperative evaluation of colorectal liver metastases: comparison between gadoxetic acid-enhanced 3.0-T MRI and contrast-enhanced MDCT with histopathological correlation. Eur Radiol 23:2187–2196CrossRefPubMed Scharitzer M, Ba-Ssalamah A, Ringl H, Kölblinger C, Grünberger T, Weber M, Schima W (2013) Preoperative evaluation of colorectal liver metastases: comparison between gadoxetic acid-enhanced 3.0-T MRI and contrast-enhanced MDCT with histopathological correlation. Eur Radiol 23:2187–2196CrossRefPubMed
36.
go back to reference Kim YK, Park G, Kim CS, Yu HC, Han YM (2012) Diagnostic efficacy of gadoxetic acid-enhanced MRI for the detection and characterisation of liver metastases: comparison with multidetector-row CT. Br J Radiol 85:539–547CrossRefPubMedPubMedCentral Kim YK, Park G, Kim CS, Yu HC, Han YM (2012) Diagnostic efficacy of gadoxetic acid-enhanced MRI for the detection and characterisation of liver metastases: comparison with multidetector-row CT. Br J Radiol 85:539–547CrossRefPubMedPubMedCentral
37.
go back to reference Han NY, Park BJ, Sung DJ et al (2014) Chemotherapy-induced focal hepatopathy in patients with gastrointestinal malignancy: gadoxetic acid–enhanced and diffusion-weighted MR Imaging with clinical-pathologic correlation. Radiology 271:416–425CrossRefPubMed Han NY, Park BJ, Sung DJ et al (2014) Chemotherapy-induced focal hepatopathy in patients with gastrointestinal malignancy: gadoxetic acid–enhanced and diffusion-weighted MR Imaging with clinical-pathologic correlation. Radiology 271:416–425CrossRefPubMed
38.
go back to reference Péporté AR, Sommer WH, Nikolaou K, Reiser MF, Zech CJ (2013) Imaging features of intrahepatic cholangiocarcinoma in Gd-EOB-DTPA-enhanced MRI. Eur J Radiol 82:101–106CrossRef Péporté AR, Sommer WH, Nikolaou K, Reiser MF, Zech CJ (2013) Imaging features of intrahepatic cholangiocarcinoma in Gd-EOB-DTPA-enhanced MRI. Eur J Radiol 82:101–106CrossRef
39.
go back to reference Park HJ, Kim YK, Park MJ, Lee WJ (2013) Small intrahepatic mass-forming cholangiocarcinoma: target sign on diffusion-weighted imaging for differentiation from hepatocellular carcinoma. Abdom Imaging 38:793–801CrossRefPubMed Park HJ, Kim YK, Park MJ, Lee WJ (2013) Small intrahepatic mass-forming cholangiocarcinoma: target sign on diffusion-weighted imaging for differentiation from hepatocellular carcinoma. Abdom Imaging 38:793–801CrossRefPubMed
40.
go back to reference Verloh N, Haimerl M, Rennert J et al (2013) Impact of liver cirrhosis on liver enhancement at Gd-EOB-DTPA enhanced MRI at 3 Tesla. Eur J Radiol 82:1710–1715CrossRefPubMed Verloh N, Haimerl M, Rennert J et al (2013) Impact of liver cirrhosis on liver enhancement at Gd-EOB-DTPA enhanced MRI at 3 Tesla. Eur J Radiol 82:1710–1715CrossRefPubMed
41.
go back to reference Phongkitkarun S, Limsamutpetch K, Tannaphai P, Jatchavala J (2013) Added value of hepatobiliary phase gadoxetic acid-enhanced MRI for diagnosing hepatocellular carcinoma in high-risk patients. World J Gastroenterol 19:8357–8365CrossRefPubMedPubMedCentral Phongkitkarun S, Limsamutpetch K, Tannaphai P, Jatchavala J (2013) Added value of hepatobiliary phase gadoxetic acid-enhanced MRI for diagnosing hepatocellular carcinoma in high-risk patients. World J Gastroenterol 19:8357–8365CrossRefPubMedPubMedCentral
42.
go back to reference Haimerl M, Verloh N, Fellner C et al (2014) MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score. Sci Rep 4:5621CrossRefPubMedPubMedCentral Haimerl M, Verloh N, Fellner C et al (2014) MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score. Sci Rep 4:5621CrossRefPubMedPubMedCentral
43.
go back to reference Verloh N, Haimerl M, Zeman F et al (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. Eur Radiol 24:1013–1019CrossRefPubMed Verloh N, Haimerl M, Zeman F et al (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. Eur Radiol 24:1013–1019CrossRefPubMed
44.
go back to reference Cereser L, Furlan A, Bagatto D et al (2010) Comparison of portal venous and delayed phases of gadolinium-enhanced magnetic resonance imaging study of cirrhotic liver for the detection of contrast washout of hypervascular hepatocellular carcinoma. J Comput Assist Tomogr 34:706–711 (reviewer 4, comment 3)CrossRefPubMed Cereser L, Furlan A, Bagatto D et al (2010) Comparison of portal venous and delayed phases of gadolinium-enhanced magnetic resonance imaging study of cirrhotic liver for the detection of contrast washout of hypervascular hepatocellular carcinoma. J Comput Assist Tomogr 34:706–711 (reviewer 4, comment 3)CrossRefPubMed
45.
go back to reference Bartolozzi C, Battaglia V, Bargellini I et al (2013) Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers. Abdom Imaging 38:290–296CrossRefPubMed Bartolozzi C, Battaglia V, Bargellini I et al (2013) Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers. Abdom Imaging 38:290–296CrossRefPubMed
46.
go back to reference Yu MH, Kim JH, Yoon JH et al (2014) Small (≤1-cm) hepatocellular carcinoma: diagnostic performance and imaging features at gadoxetic acid-enhanced MR imaging. Radiology 271:748–760CrossRefPubMed Yu MH, Kim JH, Yoon JH et al (2014) Small (≤1-cm) hepatocellular carcinoma: diagnostic performance and imaging features at gadoxetic acid-enhanced MR imaging. Radiology 271:748–760CrossRefPubMed
47.
go back to reference Granito A, Galassi M, Piscaglia F et al (2013) Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study. Aliment Pharmacol Ther 37:355–363 (reviewer 3, comment 5)CrossRefPubMed Granito A, Galassi M, Piscaglia F et al (2013) Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study. Aliment Pharmacol Ther 37:355–363 (reviewer 3, comment 5)CrossRefPubMed
48.
go back to reference Kitajima K, Yoshikawa T, Seo Y et al (2011) A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings. Magn Reson Imaging 29:579–583CrossRefPubMed Kitajima K, Yoshikawa T, Seo Y et al (2011) A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings. Magn Reson Imaging 29:579–583CrossRefPubMed
49.
go back to reference Shin NY, Kim MJ, Lim JS et al (2012) Accuracy of gadoxetic acid-enhanced magnetic resonance imaging for the diagnosis of sinusoidal obstruction syndrome in patients with chemotherapy-treated colorectal liver metastases. Eur Radiol 22:864–871CrossRefPubMed Shin NY, Kim MJ, Lim JS et al (2012) Accuracy of gadoxetic acid-enhanced magnetic resonance imaging for the diagnosis of sinusoidal obstruction syndrome in patients with chemotherapy-treated colorectal liver metastases. Eur Radiol 22:864–871CrossRefPubMed
50.
go back to reference Lee NK, Kim S, Lee JW et al (2009) Biliary MR imaging with Gd-EOB-DTPA and its clinical applications. Radiographics 29:1707–1724CrossRefPubMed Lee NK, Kim S, Lee JW et al (2009) Biliary MR imaging with Gd-EOB-DTPA and its clinical applications. Radiographics 29:1707–1724CrossRefPubMed
51.
go back to reference Boraschi P, Donati F (2013) Biliary-enteric anastomoses: spectrum of findings on Gd-EOB-DTPA-enhanced MR cholangiography. Abdom Imaging 38:1351–1359CrossRefPubMed Boraschi P, Donati F (2013) Biliary-enteric anastomoses: spectrum of findings on Gd-EOB-DTPA-enhanced MR cholangiography. Abdom Imaging 38:1351–1359CrossRefPubMed
52.
go back to reference Boraschi P, Donati F (2014) Postoperative biliary adverse events following orthotopic liver transplantation: assessment with magnetic resonance cholangiography. World J Gastroenterol 20:11080–11094CrossRefPubMedPubMedCentral Boraschi P, Donati F (2014) Postoperative biliary adverse events following orthotopic liver transplantation: assessment with magnetic resonance cholangiography. World J Gastroenterol 20:11080–11094CrossRefPubMedPubMedCentral
Metadata
Title
ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents
Authors
E. Neri
M. A. Bali
A. Ba-Ssalamah
P. Boraschi
G. Brancatelli
F. Caseiro Alves
L. Grazioli
T. Helmberger
J. M. Lee
R. Manfredi
L. Martì-Bonmatì
C. Matos
E. M. Merkle
B. Op De Beeck
W. Schima
S. Skehan
V. Vilgrain
C. Zech
C. Bartolozzi
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 4/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3900-3

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