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European Radiology
Published in: European Radiology 5/2015

01-05-2015 | Head and Neck

Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: a multicentre, prospective accuracy study with histopathological correlation

Authors: Hervé J. Brisse, Pim de Graaf, Paolo Galluzzi, Kristel Cosker, Philippe Maeder, Sophia Göricke, Firazia Rodjan, Marcus C. de Jong, Alexia Savignoni, Isabelle Aerts, Laurence Desjardins, Annette C. Moll, Theodora Hadjistilianou, Paolo Toti, Paul van der Valk, Jonas A. Castelijns, Xavier Sastre-Garau, on behalf of the European Retinoblastoma Imaging Collaboration (ERIC)

Published in: European Radiology | Issue 5/2015

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Abstract

Objectives

To assess the accuracy of high-resolution (HR) magnetic resonance imaging (MRI) in diagnosing early-stage optic nerve (ON) invasion in a retinoblastoma cohort.

Methods

This IRB-approved, prospective multicenter study included 95 patients (55 boys, 40 girls; mean age, 29 months). 1.5-T MRI was performed using surface coils before enucleation, including spin-echo unenhanced and contrast-enhanced (CE) T1-weighted sequences (slice thickness, 2 mm; pixel size <0.3 × 0.3 mm2). Images were read by five neuroradiologists blinded to histopathologic findings. ROC curves were constructed with AUC assessment using a bootstrap method.

Results

Histopathology identified 41 eyes without ON invasion and 25 with prelaminar, 18 with intralaminar and 12 with postlaminar invasion. All but one were postoperatively classified as stage I by the International Retinoblastoma Staging System. The accuracy of CE-T1 sequences in identifying ON invasion was limited (AUC = 0.64; 95 % CI, 0.55 – 0.72) and not confirmed for postlaminar invasion diagnosis (AUC = 0.64; 95 % CI, 0.47 – 0.82); high specificities (range, 0.64 – 1) and negative predictive values (range, 0.81 – 0.97) were confirmed.

Conclusion

HR-MRI with surface coils is recommended to appropriately select retinoblastoma patients eligible for primary enucleation without the risk of IRSS stage II but cannot substitute for pathology in differentiating the first degrees of ON invasion.

Key Points

• HR-MRI excludes advanced optic nerve invasion with high negative predictive value.
• HR-MRI accurately selects patients eligible for primary enucleation.
• Diagnosis of early stages of optic nerve invasion still relies on pathology.
• Several physiological MR patterns may mimic optic nerve invasion.
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Metadata
Title
Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: a multicentre, prospective accuracy study with histopathological correlation
Authors
Hervé J. Brisse
Pim de Graaf
Paolo Galluzzi
Kristel Cosker
Philippe Maeder
Sophia Göricke
Firazia Rodjan
Marcus C. de Jong
Alexia Savignoni
Isabelle Aerts
Laurence Desjardins
Annette C. Moll
Theodora Hadjistilianou
Paolo Toti
Paul van der Valk
Jonas A. Castelijns
Xavier Sastre-Garau
on behalf of the European Retinoblastoma Imaging Collaboration (ERIC)
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3514-1

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