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01-03-2015 | Musculoskeletal

Exact monitoring of aortic diameters in Marfan patients without gadolinium contrast: intraindividual comparison of 2D SSFP imaging with 3D CE-MRA and echocardiography

Authors: Simon Veldhoen, Cyrus Behzadi, Thorsten Derlin, Meike Rybczinsky, Yskert von Kodolitsch, Sara Sheikhzadeh, Frank Oliver Henes, Thorsten Alexander Bley, Gerhard Adam, Peter Bannas

Published in: European Radiology | Issue 3/2015

Abstract

Purpose

To assess whether ECG-gated non-contrast 2D steady-state free precession (SSFP) imaging allows for exact monitoring of aortic diameters in Marfan syndrome (MFS) patients using non-ECG-gated contrast-enhanced 3D magnetic resonance angiography (CE-MRA) and echocardiography for intraindividual comparison.

Methods

Non-ECG-gated CE-MRA and ECG-gated non-contrast SSFP at 1.5 T were prospectively performed in 50 patients. Two readers measured aortic diameters on para-sagittal images identically aligned with the aortic arch at the sinuses of Valsalva, sinotubular junction, ascending/descending aorta and aortic arch. Image quality was assessed on a three-point scale. Aortic root diameters acquired by echocardiography were used as reference.

Results

Intra- and interobserver variances were smaller for SSFP at the sinuses of Valsalva (p = 0.002; p = 0.002) and sinotubular junction (p = 0.014; p = 0.043). Image quality was better in SSFP than in CE-MRA at the sinuses of Valsalva (p < 0.0001), sinotubular junction (p < 0.0001) and ascending aorta (p = 0.02). CE-MRA yielded higher diameters than SSFP at the sinuses of Valsalva (mean bias, 2.5 mm; p < 0.0001), and comparison with echocardiography confirmed a higher bias for CE-MRA (7.2 ± 3.4 mm vs. SSFP, 4.7 ± 2.6 mm).

Conclusion

ECG-gated non-contrast 2D SSFP imaging provides superior image quality with higher validity compared to non-ECG-gated contrast-enhanced 3D imaging. Since CE-MRA requires contrast agents with potential adverse effects, non-contrast SSFP imaging is an appropriate alternative for exact and riskless aortic monitoring of MFS patients.

Key Points

• ECG-gated 2D SSFP imaging provides better image quality than non-ECG-gated contrast-enhanced 3D MRA

• ECG-gated 2D SSFP imaging provides higher reproducibility than non-ECG-gated contrast-enhanced 3D MRA

• 2D SSFP imaging provides higher validity than 3D MRA using echocardiography as reference

• ECG-gated non-contrast 2D SFFP imaging allows for riskless monitoring of Marfan patients

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Title: Exact monitoring of aortic diameters in Marfan patients without gadolinium contrast: intraindividual comparison of 2D SSFP imaging with 3D CE-MRA and echocardiography
Authors: Simon Veldhoen
Cyrus Behzadi
Thorsten Derlin
Meike Rybczinsky
Yskert von Kodolitsch
Sara Sheikhzadeh
Frank Oliver Henes
Thorsten Alexander Bley
Gerhard Adam
Peter Bannas
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 3/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3457-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Exact monitoring of aortic diameters in Marfan patients without gadolinium contrast: intraindividual comparison of 2D SSFP imaging with 3D CE-MRA and echocardiography

Abstract

Purpose

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Key Points

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