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European Radiology
Published in: European Radiology 3/2015

01-03-2015 | Neuro

Time of flight MR angiography assessment casts doubt on the association between transient global amnesia and intracranial jugular venous reflux

Authors: Yeonah Kang, Eunhee Kim, Jae Hyoung Kim, Byung Se Choi, Cheolkyu Jung, Yun Jung Bae, Kyung Mi Lee, Dong Hoon Lee

Published in: European Radiology | Issue 3/2015

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Abstract

Purpose

Evidence of intracranial venous reflux flow due to jugular venous reflux (JVR) on time of flight (TOF) MR angiography (MRA) is thought to be highly associated with transient global amnesia (TGA)—evidence that supports the venous congestion theory of TGA pathophysiology. However, recent studies indicate that intracranial JVR on TOF MRA is occasionally observed in normal elderly. Therefore, the purpose of this study was to compare the prevalence of intracranial JVR on TOF MRA in patients with TGA and two control groups.

Methods

Three age- and sex-matched groups of subjects that received MRI and MRA were enrolled. The groups comprised 167 patients with TGA, 167 visitors to the emergency room (ER) and 167 visitors to a health promotion centre (HPC). Intracranial JVR was defined as abnormal venous signals in the inferior petrosal, sigmoid and/or transverse sinuses on TOF MRA. The prevalence of intracranial JVR was assessed across the three groups.

Results

Intracranial JVR was seen in seven (4.2 %) TGA patients, eight (4.8 %) ER visitors and three (1.8 %) HPC visitors, respectively. No statistically significant differences were observed among the three groups.

Conclusion

TGA patients showed a low prevalence of intracranial JVR on TOF MRA, and no statistical differences were found in comparison with control groups.

Key Points

• Intracranial jugular venous reflux was observed by TOF MRA.
• TGA patients showed a low prevalence of intracranial JVR on MRA.
• TGA patients showed no difference in prevalence of JVR compared with controls.
Literature
1.
Bartsch T, Deuschl G (2010) Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 9:205–214CrossRefPubMed
2.
3.
4.
Sander D, Winbeck K, Etgen T, Knapp R, Klingelhofer J, Conrad B (2000) Disturbance of venous flow patterns in patients with transient global amnesia. Lancet 356:1982–1984CrossRefPubMed
5.
Nedelmann M, Eicke BM, Dieterich M (2005) Increased incidence of jugular valve insufficiency in patients with transient global amnesia. J Neurol 252:1482–1486CrossRefPubMed
6.
Chung CP, Hsu HY, Chao AC, Chang FC, Sheng WY, Hu HH (2006) Detection of intracranial venous reflux in patients of transient global amnesia. Neurology 66:1873–1877CrossRefPubMed
7.
Agosti C, Borroni B, Akkawi NM, Padovani A (2010) Cerebrovascular risk factors and triggers in transient global amnesia patients with and without jugular valve incompetence: results from a sample of 243 patients. Eur Neurol 63:291–294CrossRefPubMed
8.
Maalikjy Akkawi N, Agosti C, Anzola GP et al (2003) Transient global amnesia: a clinical and sonographic study. Eur Neurol 49:67–71CrossRefPubMed
9.
Akkawi NM, Agosti C, Rozzini L, Anzola GP, Padovani A (2001) Transient global amnesia and disturbance of venous flow patterns. Lancet 357:957CrossRefPubMed
10.
Akkawi NM, Agosti C, Rozzini L, Anzola GP, Padovani A (2001) Transient global amnesia and venous flow patterns. Lancet 357:639CrossRefPubMed
11.
Cejas C, Cisneros LF, Lagos R, Zuk C, Ameriso SF (2010) Internal jugular vein valve incompetence is highly prevalent in transient global amnesia. Stroke 41:67–71CrossRefPubMed
12.
Chung CP, Hsu HY, Chao AC, Sheng WY, Soong BW, Hu HH (2007) Transient global amnesia: cerebral venous outflow impairment-insight from the abnormal flow patterns of the internal jugular vein. Ultrasound Med Biol 33:1727–1735CrossRefPubMed
13.
Schreiber SJ, Doepp F, Klingebiel R, Valdueza JM (2005) Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. J Neurol Neurosurg Psychiatry 76:509–513CrossRefPubMedCentralPubMed
14.
Kim E, Kim JH, Choi BS, Jung C, Lee DH (2014) MRI and MR angiography findings to differentiate jugular venous reflux from cavernous dural arteriovenous fistula. AJR Am J Roentgenol 202:839–846CrossRefPubMed
15.
Uchino A, Nomiyama K, Takase Y et al (2007) Retrograde flow in the dural sinuses detected by three-dimensional time-of-flight MR angiography. Neuroradiology 49:211–215CrossRefPubMed
16.
Inano S, Itoh D, Takao H et al (2010) High signal intensity in the dural sinuses on 3D-TOF MR angiography at 3.0 T. Clin Imaging 34:332–336CrossRefPubMed
17.
Kudo K, Terae S, Ishii A et al (2004) Physiologic change in flow velocity and direction of dural venous sinuses with respiration: MR venography and flow analysis. AJNR Am J Neuroradiol 25:551–557PubMed
18.
Weon YC, Kim JH, Lee JS, Kim SY (2008) Optimal diffusion-weighted imaging protocol for lesion detection in transient global amnesia. AJNR Am J Neuroradiol 29:1324–1328CrossRefPubMed
19.
Lee HY, Kim JH, Weon YC et al (2007) Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. Neuroradiology 49:481–487CrossRefPubMed
20.
Choi BS, Kim JH, Jung C, Kim SY (2012) High-resolution diffusion-weighted imaging increases lesion detectability in patients with transient global amnesia. AJNR Am J Neuroradiol 33:1771–1774CrossRefPubMed
21.
Watanabe K, Kakeda S, Watanabe R, Ohnari N, Korogi Y (2013) Normal flow signal of the pterygoid plexus on 3 T MRA in patients without DAVF of the cavernous sinus. AJNR Am J Neuroradiol 34:1232–1236CrossRefPubMed
22.
Baracchini C, Tonello S, Farina F et al (2012) Jugular veins in transient global amnesia: innocent bystanders. Stroke 43:2289–2292CrossRefPubMed
23.
Lochner P, Nedelmann M, Kaps M, Stolz E (2013) Jugular valve incompetence in transient global amnesia. A problem revisited. J Neuroimaging. doi:10.​1111/​jon.​12042
Metadata
Title
Time of flight MR angiography assessment casts doubt on the association between transient global amnesia and intracranial jugular venous reflux
Authors
Yeonah Kang
Eunhee Kim
Jae Hyoung Kim
Byung Se Choi
Cheolkyu Jung
Yun Jung Bae
Kyung Mi Lee
Dong Hoon Lee
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3448-7

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