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European Radiology
Published in: European Radiology 3/2015

01-03-2015 | Breast

Dixon imaging-based partial volume correction improves quantification of choline detected by breast 3D-MRSI

Authors: Lenka Minarikova, Stephan Gruber, Wolfgang Bogner, Katja Pinker-Domenig, Pascal A. T. Baltzer, Thomas H. Helbich, Siegfried Trattnig, Marek Chmelik

Published in: European Radiology | Issue 3/2015

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Abstract

Objectives

Our aim was to develop a partial volume (PV) correction method of choline (Cho) signals detected by breast 3D-magnetic resonance spectroscopic imaging (3D-MRSI), using information from water/fat-Dixon MRI.

Methods

Following institutional review board approval, five breast cancer patients were measured at 3 T. 3D-MRSI (1 cm3 resolution, duration ~11 min) and Dixon MRI (1 mm3, ~2 min) were measured in vivo and in phantoms. Glandular/lesion tissue was segmented from water/fat-Dixon MRI and transformed to match the resolution of 3D-MRSI. The resulting PV values were used to correct Cho signals. Our method was validated on a two-compartment phantom (choline/water and oil). PV values were correlated with the spectroscopic water signal. Cho signal variability, caused by partial-water/fat content, was tested in 3D-MRSI voxels located in/near malignant lesions.

Results

Phantom measurements showed good correlation (r = 0.99) with quantified 3D-MRSI water signals, and better homogeneity after correction. The dependence of the quantified Cho signal on the water/fat voxel composition was significantly (p < 0.05) reduced using Dixon MRI-based PV correction, compared to the original uncorrected data (1.60-fold to 3.12-fold) in patients.

Conclusions

The proposed method allows quantification of the Cho signal in glandular/lesion tissue independent of water/fat composition in breast 3D-MRSI. This can improve the reproducibility of breast 3D-MRSI, particularly important for therapy monitoring.

Key Points

• Choline signal in breast spectroscopic imaging can be corrected using Dixon MRI.
• Partial volume-matched MRI provides comparable information with quantified 3D-MRSI water signal.
• Corrected breast 3D-MRSI could improve reproducibility for follow-up studies and inter-subject comparison.
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Metadata
Title
Dixon imaging-based partial volume correction improves quantification of choline detected by breast 3D-MRSI
Authors
Lenka Minarikova
Stephan Gruber
Wolfgang Bogner
Katja Pinker-Domenig
Pascal A. T. Baltzer
Thomas H. Helbich
Siegfried Trattnig
Marek Chmelik
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3425-1

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