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Published in: European Radiology 10/2014

01-10-2014 | Cardiac

Meta-analysis: diagnostic accuracy of coronary CT angiography with prospective ECG gating based on step-and-shoot, Flash and volume modes for detection of coronary artery disease

Authors: Linfeng Yang, Tao Zhou, Ruijie Zhang, Lin Xu, Zhaohui Peng, Juan Ding, Sen Wang, Min Li, Gang Sun

Published in: European Radiology | Issue 10/2014

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Abstract

Objectives

To investigate the diagnostic performance of coronary computed tomographic angiography (CCTA) with prospective electrocardiograph (ECG) gating based on step-and-shoot (SAS), Flash and volume imaging modes.

Methods

We searched the electronic databases PubMed for all published studies regarding CCTA. We used an exact binomial rendition of the bivariate mixed-effects regression model developed for synthesis of diagnostic data.

Results

A total of 21,852 segments, 4,851 vessels and 1,375 patients were identified using database searches. Patient-level pooled sensitivity was 0.99 (95 % confidence interval [CI], 0.98–1.00); specificity was 0.88 (CI, 0.85–0.91). The results showed that the sensitivity and specificity for detection of significant stenosis did not differ in the three protocols (P = 0.24). No heterogeneity was found at the patient level for sensitivity (Q = 26.23; P = 0.12; I 2 = 27.56 % [CI, 0.00-67.02 %]) and specificity (Q = 19.54; P = 0.42; I 2 = 2.78 % [CI, 0.00-66.26 %]).

Conclusions

CCTA with prospective ECG gating has similar high diagnostic value to rule out CAD in all three presented modes.

Key Points

The accuracy of CCTA with different prospective ECG gating is similar
CCTA with prospective ECG gating is effective to exclude coronary artery disease
The radiation dose of volume mode increases with higher heart rate
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Metadata
Title
Meta-analysis: diagnostic accuracy of coronary CT angiography with prospective ECG gating based on step-and-shoot, Flash and volume modes for detection of coronary artery disease
Authors
Linfeng Yang
Tao Zhou
Ruijie Zhang
Lin Xu
Zhaohui Peng
Juan Ding
Sen Wang
Min Li
Gang Sun
Publication date
01-10-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3221-y

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