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Seminars in Immunopathology
Published in: Seminars in Immunopathology 6/2022

Open Access 11-04-2022 | Kidney Cancer | Review

Tissue-resident memory T cells in the kidney

Authors: Nariaki Asada, Pauline Ginsberg, Nicola Gagliani, Hans-Willi Mittrücker, Ulf Panzer

Published in: Seminars in Immunopathology | Issue 6/2022

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Abstract

The identification of tissue-resident memory T cells (TRM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that TRM cells are induced after an acute T-cell response, remain in peripheral organs for several years, and contribute to both an efficient host defense and autoimmune disease. TRM cells are found in the kidneys of healthy individuals and patients with various kidney diseases. A better understanding of these cells and their therapeutic targeting might provide new treatment options for infections, autoimmune diseases, graft rejection, and cancer. In this review, we address the definition, phenotype, and developmental mechanisms of TRM cells. Then, we further discuss the current understanding of TRM cells in kidney diseases, such as infection, autoimmune disease, cancer, and graft rejection after transplantation.
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Metadata
Title
Tissue-resident memory T cells in the kidney
Authors
Nariaki Asada
Pauline Ginsberg
Nicola Gagliani
Hans-Willi Mittrücker
Ulf Panzer
Publication date
11-04-2022
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 6/2022
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-022-00927-7

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