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01-10-2020 | Rheumatoid Arthritis | Review

The interplay between immunosenescence and age-related diseases

Authors: Florencia Barbé-Tuana, Giselle Funchal, Carine Raquel Richter Schmitz, Rafael Moura Maurmann, Moisés E. Bauer

Published in: Seminars in Immunopathology | Issue 5/2020

Abstract

The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28⁻), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.

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Title: The interplay between immunosenescence and age-related diseases
Authors: Florencia Barbé-Tuana
Giselle Funchal
Carine Raquel Richter Schmitz
Rafael Moura Maurmann
Moisés E. Bauer
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keywords: Rheumatoid Arthritis
Cytokines
Published in: Seminars in Immunopathology / Issue 5/2020
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-020-00806-z

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