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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2013

01-07-2013 | Review

Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity

Authors: Marko Radic, Tony N. Marion

Published in: Seminars in Immunopathology | Issue 4/2013

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Abstract

Autoantibodies to DNA and histones (chromatin) are the defining antigen specificity in systemic lupus erythematosus (SLE) and related musculoskeletal disorders but the mechanisms responsible for their induction remain mysterious. That situation rapidly changed once neutrophil extracellular chromatin traps (NETs) were discovered and observed to play a conserved role in innate immune responses to a broad variety of microbial pathogens. At the center of an infectious process, neutrophils exert various antimicrobial defenses, including the release of nuclear chromatin into the extracellular space. The externalized NETs, a complex meshwork of nuclear chromatin and antimicrobial proteins, serve to immobilize and degrade microbial pathogens. Here, we critically evaluate the evidence supporting NETs versus apoptotic bodies as a source for nuclear antigens in autoimmunity. We also discuss the possibility that NET chromatin forms an essential component of immune deposits in the pathogenesis of glomerulonephritis in SLE and other autoimmune immune complex diseases.
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Metadata
Title
Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity
Authors
Marko Radic
Tony N. Marion
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2013
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-013-0376-6

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