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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2013

01-07-2013 | Review

Neutrophils in innate and adaptive immunity

Authors: Sébastien Jaillon, Maria Rosaria Galdiero, Davide Del Prete, Marco Antonio Cassatella, Cecilia Garlanda, Alberto Mantovani

Published in: Seminars in Immunopathology | Issue 4/2013

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Abstract

Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challenged by recent lines of evidence demonstrating the expression of an increasing number of cytokines and effector molecules by neutrophils. Moreover, in analogy with their “big brother” macrophages, neutrophils integrate the environmental signals and can be polarized towards an antitumoural or protumoural phenotype. Neutrophils are a major source of humoral fluid phase pattern recognition molecules and thus contribute to the humoral arm of innate immunity. Neutrophils cross talk and shape the maturation and effector functions of other leukocytes in a direct or indirect manner, through cell–cell contact or cytokine production, respectively. Therefore, neutrophils are integrated in the activation and regulation of the innate and adaptive immune system and play an important role in the resolution or exacerbation of diverse pathologies, including infections, chronic inflammation, autoimmunity and cancer.
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Metadata
Title
Neutrophils in innate and adaptive immunity
Authors
Sébastien Jaillon
Maria Rosaria Galdiero
Davide Del Prete
Marco Antonio Cassatella
Cecilia Garlanda
Alberto Mantovani
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2013
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-013-0374-8

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