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Seminars in Immunopathology
Published in: Seminars in Immunopathology 3/2005

01-01-2005 | Original Article

Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9

Authors: Tomoki Ito, Yui-Hsi Wang, Yong-Jun Liu

Published in: Seminars in Immunopathology | Issue 3/2005

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Abstract

Plasmacytoid dendritic cell (pDC) precursors, also called type I IFN (α/β/ω)-producing cells (IPCs), are the key effectors in the innate immune system because of their extraordinary capacity to produce type I IFNs against microbial infection, particularly viral infection. In contrast to myeloid DCs, human pDC/IPCs selectively express Toll-like receptor (TLR) 7 and TLR9 within the endosomal compartment. These receptors are specifically designed to recognize the nucleoside-based products derived from RNA viruses and DNA viruses. Therefore, this expression profile potentially enables pDC/IPCs to sense a variety of viruses. Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system.
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Metadata
Title
Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9
Authors
Tomoki Ito
Yui-Hsi Wang
Yong-Jun Liu
Publication date
01-01-2005
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 3/2005
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-004-0180-4

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