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Published in: CardioVascular and Interventional Radiology 9/2021

Open Access 01-09-2021 | Hepatocellular Carcinoma | Case Report

Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum

Authors: L. Luerken, M. Doppler, S. M. Brunner, H. J. Schlitt, W. Uller

Published in: CardioVascular and Interventional Radiology | Issue 9/2021

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Abstract

Electrochemotherapy (ECT) is a novel non-thermal ablative technique that combines chemotherapy and the application of electric pulses for reversible cell membrane electroporation. This method was recently performed in the treatment of deep-seated liver tumors during open surgery but experience about percutaneous ECT is rare and further developments like combination of percutaneous ECT with stereotactic navigated devices may be very promising. We report on a case of a 4.7 × 4.5 × 3.5 cm unresectable HCC at the hepatic hilum adjacent to the major vessels and the bile duct that was successfully treated using percutaneous ECT in combination with stereotactic navigation. Follow-up imaging 6 weeks and 6 months after ECT showed complete response.
Literature
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go back to reference Mir LM, Gehl J, Sersa G, Collins CG, Garbay J-R, Billard V, et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur J Cancer Suppl. 2006;4:14–25. https://doi.org/10.1016/j.ejcsup.2006.08.003.CrossRef Mir LM, Gehl J, Sersa G, Collins CG, Garbay J-R, Billard V, et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur J Cancer Suppl. 2006;4:14–25. https://​doi.​org/​10.​1016/​j.​ejcsup.​2006.​08.​003.CrossRef
Metadata
Title
Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum
Authors
L. Luerken
M. Doppler
S. M. Brunner
H. J. Schlitt
W. Uller
Publication date
01-09-2021
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 9/2021
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-021-02841-1

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