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01-04-2005 | Original Article

Prevalence of vitamin D insufficiency in postmenopausal south Indian women

Author: C. V. Harinarayan

Published in: Osteoporosis International | Issue 4/2005

Abstract

Aim: To evaluate the dietary calcium and vitamin D status in south Indian postmenopausal women. Methods: Postmenopausal women (n=164) were evaluated for their daily dietary calcium intake, phytate to calcium ratio, and bone mineral parameters. Their serum leutinizing hormone (LH), follicle-stimulating hormone (FSH), 25-hydroxyvitamin D (25[OH]D), and parathyroid hormone levels (PTH) were measured. Results: Their age and BMI were 59.5 ± 8 years and 27 ± 5 kg/m², respectively. Their daily dietary intake of calcium was 323 ± 66 mg/day; phytate to calcium ratio, 0.56±0.1; LH, 26 ± 13.5 µIU/l; and FSH, 62.6 ± 30 µIU/l. Their dietary intake of calcium was low compared with the recommended daily/dietary allowance (RDA) of the Indian Council of Medical Research (ICMR) for the Indian population. Of the 164 patients studied, based on population-based reference values, 126 (77%) had normal 25(OH)D levels (9–37.6 ng/ml), and 38 (23%) had 25(OH)D deficiency. Using functional health-based reference values, 30 (18%) patients had normal 25(OH)D levels (>20 ng/ml), 85 (52%) had 25(OH)D insufficiency (10–20 ng/ml), and 49(30%) had 25(OH)D deficiency (<10 ng/ml). PTH and serum alkaline phosphatase (SAP) was significantly high in patients with 25(OH)D deficiency (p<0.05) compared with those with normal 25(OH)D levels. There was a negative correlation between 25(OH)D and PTH (r=−0.2; p<0.007) and SAP (r=−0.2; p<0.001). Dietary calcium correlated positively with dietary phosphates (r=0.8; p<0.001) and phytate to calcium ratio (r=0.75; p<0.001). Conclusions: Population-based reference values underdiagnosed vitamin D insufficiency and overdiagnosed normal vitamin D status. The diet was insufficient in calcium and high in phytate. About 82% of the study group had varying degrees of low 25-hydroxyvitamin D levels. The quality of diet has to be improved with enrichment/supplementation of calcium and vitamin D to suppress secondary hyperparathyroidism-induced bone loss and risk of fractures.

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Title: Prevalence of vitamin D insufficiency in postmenopausal south Indian women
Author: C. V. Harinarayan
Publication date: 01-04-2005
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 4/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-004-1703-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence of vitamin D insufficiency in postmenopausal south Indian women

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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