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Osteoporosis International
Published in: Osteoporosis International 4/2005

01-04-2005 | Original Article

Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa

Authors: Kai G. Kahl, Sebastian Rudolf, Leif Dibbelt, Beate M. Stoeckelhuber, Hans-Björn Gehl, Fritz Hohagen, Ulrich Schweiger

Published in: Osteoporosis International | Issue 4/2005

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Abstract

Low bone mineral density (BMD) is a frequent, often persistent complication in patients with major depressive disorder (MDD) and anorexia nervosa (AN) that increases the risk of pathologic fractures. The pathogenetic process underlying osteopenia in MDD and AN is still unclear, although several factors, including a dysbalance of cytokines, are associated with loss of bone mass. Alterations in the serum levels of cytokines have been observed in patients with MDD, AN, and other psychiatric disorders. Therefore, we examined serum levels of cytokines, markers of bone turnover, and BMD in 13 patients with MDD and a lifetime history of AN. Bone turnover markers (osteocalcin and C-terminal degradation products of type I collagen) and tumor necrosis factor α (TNF-α) in patients were significantly increased compared with those of the control group. Osteoprotegerin (OPG) in patients was significantly decreased. Eight of 13 patients (62%) displayed osteopenia at the lumbar spine. TNF-α correlated significantly with C-terminal degradation products of type I collagen, an osteoclastic marker, but significantly negatively with OPG. Our data suggest that TNF-α and OPG may play a role in the pathogenetic process underlying osteopenia in these patients.
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Metadata
Title
Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa
Authors
Kai G. Kahl
Sebastian Rudolf
Leif Dibbelt
Beate M. Stoeckelhuber
Hans-Björn Gehl
Fritz Hohagen
Ulrich Schweiger
Publication date
01-04-2005
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 4/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-004-1711-5

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