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01-09-2003 | Original Article

Regulation of skeletal remodeling by biomechanical input

Author: Janet Rubin

Published in: Osteoporosis International | Special Issue 5/2003

Excerpt

Biophysical input generated during normal physiological loading is a major determinant of bone mass and morphology. Imposing load, such as in the dominant radius of tennis players, increases bone strength and size [1]. In states where skeletal loading is decreased, such as in prolonged bed rest or in paraplegics, bone resorption is initiated. In microgravity, astronauts lose bone mineral in the lower skeleton at a rate approaching 1.6% per month [2], a remarkable loss comparable to the yearly bone loss in postmenopausal women! The mechanisms by which functional loading regulates cellular activity in bone should be of great interest to bone biologists, and might be able to be mimicked by clinical manipulations aimed at maintaining bone health. …

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Title: Regulation of skeletal remodeling by biomechanical input
Author: Janet Rubin
Publication date: 01-09-2003
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue Special Issue 5/2003
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-003-1472-6

2024 ASCO Annual Meeting

Springer Medicine

Regulation of skeletal remodeling by biomechanical input

Excerpt

2024 ASCO Annual Meeting

Springer Medicine

Excerpt

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