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Osteoporosis International
Published in: Osteoporosis International 5/2003

01-09-2003 | Original Article

Bone microarchitecture and strength

Author: David W. Dempster

Published in: Osteoporosis International | Special Issue 5/2003

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Excerpt

It has been recognized for many years that aging is accompanied by changes in bone microarchitecture and that this affects bone strength. In the second half of the 17th century, the eminent Scottish pathologist Alexander Munro observed that "there is a perpetual waste and renewal of the particles which compose the solid fibres of bone; addition from the fluids exceeding the waste during the growth of the bones; the renewal and waste keeping pretty near par in adult middle age; and the waste exceeding the supply from the liquors in old age; as is demonstrable from their weight, the bones of old people are thinner and firmer in their sides; and have larger cavities than those of young persons [1]. …
Literature
1.
Monro A (1776) The anatomy of the human bones, nerves and lacteal sac and duct. Dublin
2.
Arnold JS (1980) Trabecular patterns and shapes in aging and osteoporosis. Metab Bone Dis Rel Res 2S:297–308
3.
Mosekilde L (1988) Age-related changes in vertebral trabecular bone architecture assessed by a new method. Bone 9:247–250PubMed
4.
Thomsen JS, Ebbesen EN, Mosekilde LI (2002) Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method. Bone 31:136–142CrossRefPubMed
5.
Bell GH, Dunbar O, Beck JS, Gibb A (1967) Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tissue Res 1:75–86PubMed
6.
Ciarelli TE, Fyhrie DP, Schaffler MB, Goldstein SA (2000) Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J Bone Miner Res 15:32–40PubMed
7.
Homminga J, McCreadie BR, Ciarelli TE, et al (2002) Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. Bone 30:759–764CrossRefPubMed
8.
Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM (1985) The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tissue Int 37:594–597PubMed
9.
Legrand E, Chappard D, Pascaretti C, et al (2000) Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis. J Bone Miner Res 15:13–19PubMed
10.
Aaron JE, Shore PA, Shore RC, Beneton M, Kanis JA (2000) Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: II. Three-dimensional histology. Bone 27:277–282CrossRefPubMed
11.
Oleksik A, Ott SM, Vedi S, et al (2000) Bone structure in patients with low bone mineral density with or without vertebral fractures. J Bone Miner Res 15:1368–1375PubMed
12.
Bousson V, Meunier A, Bergot C, et al (2001) Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res 16:1308–1317PubMed
13.
Jordan GR, Loveridge N, Bell KL, et al (2000) Spatial clustering of remodeling osteons in the femoral neck cortex: a cause of weakness in hip fracture? Bone 26:305–313
14.
Crabtree N, Loveridge N, Parker M, et al (2001) Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res 16:1318–1328PubMed
15.
Duan Y, Seeman E, Turner CH (2001) The biomechanical basis of vertebral body fragility in men and women. J Bone Miner Res 16:2276–2283PubMed
16.
Duan Y, Turner CH, Kim BT, Seeman E (2001) Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res 16:2267–2275PubMed
17.
Borah B, Dufresne TE, Chmielewski PA, et al (2002) Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography. J Bone Miner Res 17:1139–1147PubMed
18.
Dufresne TE, Borah B, Chmielewski PA, et al (2002) The preservation of bone architecture by risedronate and its relationship to strength: analysis with 3-D micro-CT and mechanical testing (abstract). J Bone Miner Res 17:950
19.
Dufresne TE, Chmielewski PA, Borah B, Prenger MC (2002) One-year treatment with risedronate preserves trabecular architecture (abstract). J Bone Miner Res 17(Suppl 1):S368
20.
Hyldstrup L, Jorgensen JT, Sorensen TK, Baeksgaard L (2001) Response of cortical bone to antiresorptive treatment. Calcif Tissue Int 68:135–139PubMed
21.
Roschger P, Rinnerthaler S, Yates J, et al (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29:185–191CrossRefPubMed
22.
Cummings SR, Karpf DB, Harris F, et al (2002) Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112:281–289CrossRefPubMed
23.
Hochberg MC, Greenspan S, Wasnich RD, et al (2002) Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab 87:1586–1592
24.
Dempster DW, Cosman F, Kurland ES, et al (2001) Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J Bone Miner Res 16:1846–1853PubMed
25.
Jiang XY, Zhao J, Eriksen EF, et al (2002) Improved 3-dimensional microstructure of cancellous and cortical bone in a multicenter, double-blind, randomized, and placebo controlled study (abstract). J Bone Miner Res 17 (Suppl 1):S135
26.
Prestwood K, Gunnes M, Muchmore D, et al (2000) A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women. J Clin Endocrin Metab 85:2197–2202
27.
van Rietbergen B, Majumdar S, Newitt D, MacDonald BR (2002) High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after 1 year of idoxifene treatment. Clin Biomech (Bristol, Avon) 17:81–88
28.
Pistoia W, van Rietbergen B, Lochmuller E, et al (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842–848CrossRefPubMed
Metadata
Title
Bone microarchitecture and strength
Author
David W. Dempster
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue Special Issue 5/2003
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1474-4

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