Skip to main content
Top
Published in: Intensive Care Medicine 7/2016

01-07-2016 | Original

Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions

Authors: Jason Phua, Gavin M. Joynt, Masaji Nishimura, Yiyun Deng, Sheila Nainan Myatra, Yiong Huak Chan, Nguyen Gia Binh, Cheng Cheng Tan, Mohammad Omar Faruq, Yaseen M. Arabi, Bambang Wahjuprajitno, Shih-Feng Liu, Seyed Mohammad Reza Hashemian, Waqar Kashif, Dusit Staworn, Jose Emmanuel Palo, Younsuck Koh, ACME Study Investigators and the Asian Critical Care Clinical Trials Group

Published in: Intensive Care Medicine | Issue 7/2016

Login to get access

Abstract

Purpose

To compare the attitudes of physicians towards withholding and withdrawing life-sustaining treatments in intensive care units (ICUs) in low-middle-income Asian countries and regions with those in high-income ones, and to explore differences in the role of families and surrogates, legal risks, and financial considerations between these countries and regions.

Methods

Questionnaire study conducted in May–December 2012 on 847 physicians from 255 ICUs in 10 low-middle-income countries and regions according to the World Bank’s classification, and 618 physicians from 211 ICUs in six high-income countries and regions.

Results

After we accounted for personal, ICU, and hospital characteristics on multivariable analyses using generalised linear mixed models, physicians from low-middle-income countries and regions were less likely to limit cardiopulmonary resuscitation, mechanical ventilation, vasopressors and inotropes, tracheostomy and haemodialysis than those from high-income countries and regions. They were more likely to involve families in end-of-life care discussions and to perceive legal risks with limitation of life-sustaining treatments and do-not-resuscitate orders. Nonetheless, they were also more likely to accede to families’ requests to withdraw life-sustaining treatments in a patient with an otherwise reasonable chance of survival on financial grounds in a case scenario (adjusted odds ratio 5.05, 95 % confidence interval 2.69–9.51, P < 0.001).

Conclusions

Significant differences in ICU physicians’ self-reported practice of limiting life-sustaining treatments, the role of families and surrogates, perception of legal risks and financial considerations exist between low-middle-income and high-income Asian countries and regions.
Appendix
Available only for authorised users
Literature
1.
go back to reference Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD (2010) Critical care and the global burden of critical illness in adults. Lancet 376:1339–1346CrossRefPubMed Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD (2010) Critical care and the global burden of critical illness in adults. Lancet 376:1339–1346CrossRefPubMed
2.
go back to reference Yaguchi A, Truog RD, Curtis JR, Luce JM, Levy MM, Melot C, Vincent JL (2005) International differences in end-of-life attitudes in the intensive care unit: results of a survey. Arch Intern Med 165:1970–1975CrossRefPubMed Yaguchi A, Truog RD, Curtis JR, Luce JM, Levy MM, Melot C, Vincent JL (2005) International differences in end-of-life attitudes in the intensive care unit: results of a survey. Arch Intern Med 165:1970–1975CrossRefPubMed
3.
go back to reference Vincent JL (1990) European attitudes towards ethical problems in intensive care medicine: results of an ethical questionnaire. Intensive Care Med 16:256–264CrossRefPubMed Vincent JL (1990) European attitudes towards ethical problems in intensive care medicine: results of an ethical questionnaire. Intensive Care Med 16:256–264CrossRefPubMed
4.
go back to reference Vincent JL (1999) Forgoing life support in western European intensive care units: the results of an ethical questionnaire. Crit Care Med 27:1626–1633CrossRefPubMed Vincent JL (1999) Forgoing life support in western European intensive care units: the results of an ethical questionnaire. Crit Care Med 27:1626–1633CrossRefPubMed
5.
go back to reference Sprung CL, Cohen SL, Sjokvist P, Baras M, Bulow HH, Hovilehto S, Ledoux D, Lippert A, Maia P, Phelan D, Schobersberger W, Wennberg E, Woodcock T (2003) End-of-life practices in European intensive care units: the Ethicus Study. JAMA 290:790–797CrossRefPubMed Sprung CL, Cohen SL, Sjokvist P, Baras M, Bulow HH, Hovilehto S, Ledoux D, Lippert A, Maia P, Phelan D, Schobersberger W, Wennberg E, Woodcock T (2003) End-of-life practices in European intensive care units: the Ethicus Study. JAMA 290:790–797CrossRefPubMed
6.
go back to reference Azoulay E, Metnitz B, Sprung CL, Timsit JF, Lemaire F, Bauer P, Schlemmer B, Moreno R, Metnitz P (2009) End-of-life practices in 282 intensive care units: data from the SAPS 3 database. Intensive Care Med 35:623–630CrossRefPubMed Azoulay E, Metnitz B, Sprung CL, Timsit JF, Lemaire F, Bauer P, Schlemmer B, Moreno R, Metnitz P (2009) End-of-life practices in 282 intensive care units: data from the SAPS 3 database. Intensive Care Med 35:623–630CrossRefPubMed
7.
go back to reference Cook D, Rocker G, Marshall J, Sjokvist P, Dodek P, Griffith L, Freitag A, Varon J, Bradley C, Levy M, Finfer S, Hamielec C, McMullin J, Weaver B, Walter S, Guyatt G (2003) Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 349:1123–1132CrossRefPubMed Cook D, Rocker G, Marshall J, Sjokvist P, Dodek P, Griffith L, Freitag A, Varon J, Bradley C, Levy M, Finfer S, Hamielec C, McMullin J, Weaver B, Walter S, Guyatt G (2003) Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 349:1123–1132CrossRefPubMed
8.
go back to reference Mark NM, Rayner SG, Lee NJ, Curtis JR (2015) Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review. Intensive Care Med 41:1572–1585CrossRefPubMed Mark NM, Rayner SG, Lee NJ, Curtis JR (2015) Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review. Intensive Care Med 41:1572–1585CrossRefPubMed
9.
go back to reference Eyssallenne AP (2012) How far do you go? Intensive care in a resource-poor setting. N Engl J Med 367:8–9CrossRefPubMed Eyssallenne AP (2012) How far do you go? Intensive care in a resource-poor setting. N Engl J Med 367:8–9CrossRefPubMed
10.
go back to reference Dunser MW, Baelani I, Ganbold L (2006) A review and analysis of intensive care medicine in the least developed countries. Crit Care Med 34:1234–1242CrossRefPubMed Dunser MW, Baelani I, Ganbold L (2006) A review and analysis of intensive care medicine in the least developed countries. Crit Care Med 34:1234–1242CrossRefPubMed
11.
go back to reference Frost DW, Cook DJ, Heyland DK, Fowler RA (2011) Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med 39:1174–1189CrossRefPubMed Frost DW, Cook DJ, Heyland DK, Fowler RA (2011) Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med 39:1174–1189CrossRefPubMed
12.
go back to reference Wilkinson DJ, Truog RD (2013) The luck of the draw: physician-related variability in end-of-life decision-making in intensive care. Intensive Care Med 39:1128–1132CrossRefPubMed Wilkinson DJ, Truog RD (2013) The luck of the draw: physician-related variability in end-of-life decision-making in intensive care. Intensive Care Med 39:1128–1132CrossRefPubMed
13.
go back to reference Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM, Reinhart K, Thompson BT (2004) Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med 30:770–784CrossRefPubMed Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM, Reinhart K, Thompson BT (2004) Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med 30:770–784CrossRefPubMed
14.
go back to reference Pope TM, Hexum M (2012) Legal briefing: POLST: physician orders for life-sustaining treatment. J Clin Ethics 23:353–376PubMed Pope TM, Hexum M (2012) Legal briefing: POLST: physician orders for life-sustaining treatment. J Clin Ethics 23:353–376PubMed
16.
go back to reference Phua J, Joynt GM, Nishimura M, Deng Y, Myatra SN, Chan YH, Binh NG, Tan CC, Faruq MO, Arabi YM, Wahjuprajitno B, Liu SF, Hashemian SM, Kashif W, Staworn D, Palo JE, Koh Y, ACME Study Investigators and the Asian Critical Care Clinical Trials Group (2015) Withholding and withdrawal of life-sustaining treatments in intensive care units in Asia. JAMA Intern Med 175:363–371CrossRefPubMed Phua J, Joynt GM, Nishimura M, Deng Y, Myatra SN, Chan YH, Binh NG, Tan CC, Faruq MO, Arabi YM, Wahjuprajitno B, Liu SF, Hashemian SM, Kashif W, Staworn D, Palo JE, Koh Y, ACME Study Investigators and the Asian Critical Care Clinical Trials Group (2015) Withholding and withdrawal of life-sustaining treatments in intensive care units in Asia. JAMA Intern Med 175:363–371CrossRefPubMed
22.
go back to reference Cook DJ, Guyatt GH, Jaeschke R, Reeve J, Spanier A, King D, Molloy DW, Willan A, Streiner DL (1995) Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. Canadian Critical Care Trials Group. JAMA 273:703–708CrossRefPubMed Cook DJ, Guyatt GH, Jaeschke R, Reeve J, Spanier A, King D, Molloy DW, Willan A, Streiner DL (1995) Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. Canadian Critical Care Trials Group. JAMA 273:703–708CrossRefPubMed
23.
24.
go back to reference Sprung CL, Truog RD, Curtis JR, Joynt GM, Baras M, Michalsen A, Briegel J, Kesecioglu J, Efferen L, De Robertis E, Bulpa P, Metnitz P, Patil N, Hawryluck L, Manthous C, Moreno R, Leonard S, Hill NS, Wennberg E, McDermid RC, Mikstacki A, Mularski RA, Hartog CS, Avidan A (2014) Seeking worldwide professional consensus on the principles of end-of-life care for the critically ill. The Consensus for Worldwide End-of-Life Practice for Patients in Intensive Care Units (WELPICUS) study. Am J Respir Crit Care Med 190:855–866CrossRefPubMed Sprung CL, Truog RD, Curtis JR, Joynt GM, Baras M, Michalsen A, Briegel J, Kesecioglu J, Efferen L, De Robertis E, Bulpa P, Metnitz P, Patil N, Hawryluck L, Manthous C, Moreno R, Leonard S, Hill NS, Wennberg E, McDermid RC, Mikstacki A, Mularski RA, Hartog CS, Avidan A (2014) Seeking worldwide professional consensus on the principles of end-of-life care for the critically ill. The Consensus for Worldwide End-of-Life Practice for Patients in Intensive Care Units (WELPICUS) study. Am J Respir Crit Care Med 190:855–866CrossRefPubMed
25.
go back to reference Salahuddin N, Shafqat S, Mapara S, Khan S, Siddiqui S, Manasia R, Ahmad A (2008) End of life in the intensive care unit: knowledge and practice of clinicians from Karachi, Pakistan. Intern Med J 38:307–313CrossRefPubMed Salahuddin N, Shafqat S, Mapara S, Khan S, Siddiqui S, Manasia R, Ahmad A (2008) End of life in the intensive care unit: knowledge and practice of clinicians from Karachi, Pakistan. Intern Med J 38:307–313CrossRefPubMed
26.
go back to reference Mani RK, Mandal AK, Bal S, Javeri Y, Kumar R, Nama DK, Pandey P, Rawat T, Singh N, Tewari H, Uttam R (2009) End-of-life decisions in an Indian intensive care unit. Intensive Care Med 35:1713–1719CrossRefPubMed Mani RK, Mandal AK, Bal S, Javeri Y, Kumar R, Nama DK, Pandey P, Rawat T, Singh N, Tewari H, Uttam R (2009) End-of-life decisions in an Indian intensive care unit. Intensive Care Med 35:1713–1719CrossRefPubMed
27.
go back to reference Kapadia F, Singh M, Divatia J, Vaidyanathan P, Udwadia FE, Raisinghaney SJ, Limaye HS, Karnad DR (2005) Limitation and withdrawal of intensive therapy at the end of life: practices in intensive care units in Mumbai, India. Crit Care Med 33:1272–1275CrossRefPubMed Kapadia F, Singh M, Divatia J, Vaidyanathan P, Udwadia FE, Raisinghaney SJ, Limaye HS, Karnad DR (2005) Limitation and withdrawal of intensive therapy at the end of life: practices in intensive care units in Mumbai, India. Crit Care Med 33:1272–1275CrossRefPubMed
28.
go back to reference Yazigi A, Riachi M, Dabbar G (2005) Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study. Intensive Care Med 31:562–567CrossRefPubMed Yazigi A, Riachi M, Dabbar G (2005) Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study. Intensive Care Med 31:562–567CrossRefPubMed
29.
go back to reference Gawande AA (2014) Being mortal: illness, medicine and what matters in the end. Metropolitan Books, New York Gawande AA (2014) Being mortal: illness, medicine and what matters in the end. Metropolitan Books, New York
30.
go back to reference Koh M, Hwee PC (2015) End-of-life care in the intensive care unit: how Asia differs from the West. JAMA Intern Med 175:371–372CrossRefPubMed Koh M, Hwee PC (2015) End-of-life care in the intensive care unit: how Asia differs from the West. JAMA Intern Med 175:371–372CrossRefPubMed
34.
go back to reference Hillman KM, Cardona-Morrell M (2015) The ten barriers to appropriate management of patients at the end of their life. Intensive Care Med 41:1700–1702CrossRefPubMed Hillman KM, Cardona-Morrell M (2015) The ten barriers to appropriate management of patients at the end of their life. Intensive Care Med 41:1700–1702CrossRefPubMed
35.
go back to reference Cheng B, Xie G, Yao S, Wu X, Guo Q, Gu M, Fang Q, Xu Q, Wang D, Jin Y, Yuan S, Wang J, Du Z, Sun Y, Fang X (2007) Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med 35:2538–2546CrossRefPubMed Cheng B, Xie G, Yao S, Wu X, Guo Q, Gu M, Fang Q, Xu Q, Wang D, Jin Y, Yuan S, Wang J, Du Z, Sun Y, Fang X (2007) Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med 35:2538–2546CrossRefPubMed
36.
go back to reference Chan HM (2004) Sharing death and dying: advance directives, autonomy and the family. Bioethics 18:87–103CrossRefPubMed Chan HM (2004) Sharing death and dying: advance directives, autonomy and the family. Bioethics 18:87–103CrossRefPubMed
37.
go back to reference Kwak J, Haley WE (2005) Current research findings on end-of-life decision making among racially or ethnically diverse groups. Gerontologist 45:634–641CrossRefPubMed Kwak J, Haley WE (2005) Current research findings on end-of-life decision making among racially or ethnically diverse groups. Gerontologist 45:634–641CrossRefPubMed
38.
go back to reference Puntillo K, Nelson JE, Weissman D, Curtis R, Weiss S, Frontera J, Gabriel M, Hays R, Lustbader D, Mosenthal A, Mulkerin C, Ray D, Bassett R, Boss R, Brasel K, Campbell M, Advisory Board of the Improving Palliative Care in the ICUP (2014) Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU Advisory Board. Intensive Care Med 40:235–248CrossRefPubMed Puntillo K, Nelson JE, Weissman D, Curtis R, Weiss S, Frontera J, Gabriel M, Hays R, Lustbader D, Mosenthal A, Mulkerin C, Ray D, Bassett R, Boss R, Brasel K, Campbell M, Advisory Board of the Improving Palliative Care in the ICUP (2014) Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU Advisory Board. Intensive Care Med 40:235–248CrossRefPubMed
39.
go back to reference Bulow HH, Sprung CL, Baras M, Carmel S, Svantesson M, Benbenishty J, Maia PA, Beishuizen A, Cohen S, Nalos D (2012) Are religion and religiosity important to end-of-life decisions and patient autonomy in the ICU? The Ethicatt study. Intensive Care Med 38:1126–1133CrossRefPubMed Bulow HH, Sprung CL, Baras M, Carmel S, Svantesson M, Benbenishty J, Maia PA, Beishuizen A, Cohen S, Nalos D (2012) Are religion and religiosity important to end-of-life decisions and patient autonomy in the ICU? The Ethicatt study. Intensive Care Med 38:1126–1133CrossRefPubMed
Metadata
Title
Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions
Authors
Jason Phua
Gavin M. Joynt
Masaji Nishimura
Yiyun Deng
Sheila Nainan Myatra
Yiong Huak Chan
Nguyen Gia Binh
Cheng Cheng Tan
Mohammad Omar Faruq
Yaseen M. Arabi
Bambang Wahjuprajitno
Shih-Feng Liu
Seyed Mohammad Reza Hashemian
Waqar Kashif
Dusit Staworn
Jose Emmanuel Palo
Younsuck Koh
ACME Study Investigators and the Asian Critical Care Clinical Trials Group
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-016-4347-y

Other articles of this Issue 7/2016

Intensive Care Medicine 7/2016 Go to the issue

What's New in Intensive Care

Does this patient with AKI need RRT?