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Published in: Intensive Care Medicine 4/2005

01-04-2005 | Original

Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study

Published in: Intensive Care Medicine | Issue 4/2005

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Abstract

Objective

To evaluate the implementation and process of withholding and withdrawing life-sustaining treatment in an intensive care unit.

Design and setting

Prospective observational study in the medical intensive care unit of a university hospital in Lebanon.

Patients

Forty-five consecutive adult patients admitted to the ICU for a 1-year period and for whom a decision to withholding and withdrawal of life-sustaining treatment was made.

Measurements and results

Patients were followed up until their death. Data regarding all aspects of the implementation and the process of withholding and withdrawal of life-sustaining treatment were recorded by a senior staff nurse. Withholding and withdrawing life-sustaining treatment was applied to 9.6% of all admitted patients to ICU. Therapies were withheld in 38% and were withdrawn in 7% of patients who died. Futility of care and poor quality of life were the two most important factors supporting these decisions. The nursing staff was not involved in 26% of the decisions to limit care. Families were not implicated in 21% of the cases. Decisions were not notified in the patients’ medical record in 23% of the cases. Sixty-three percent of patients did not have a sedative or an analgesic to treat discomfort during end-of-life care.

Conclusions

Life-sustaining treatment were frequently withheld or withdrawn from adult patients in the Lebanese ICU. Cultural differences and the lack of guidelines and official statements could explain the ethical limitations of the decision-making process recorded in this study.
Literature
1.
go back to reference Azoulay E, Pochard F, Garrouste-Orgeas M, Moreau D, Montesino L, Adrie C, De Lassence A, Cohen Y, Timsit JF, on the behalf of the outcomerea group (2003) Decisions to forgo life-sustaining therapy in ICU patients independently predict hospital death. Intensive Care Med 29:1895–1901CrossRefPubMed Azoulay E, Pochard F, Garrouste-Orgeas M, Moreau D, Montesino L, Adrie C, De Lassence A, Cohen Y, Timsit JF, on the behalf of the outcomerea group (2003) Decisions to forgo life-sustaining therapy in ICU patients independently predict hospital death. Intensive Care Med 29:1895–1901CrossRefPubMed
2.
go back to reference Prendergast TJ, Luce JM (1997) Increasing incidence of withholding and withdrawal of life sustaining treatment from the critically ill. Am J Respir Crit Care Med 155:15–20PubMed Prendergast TJ, Luce JM (1997) Increasing incidence of withholding and withdrawal of life sustaining treatment from the critically ill. Am J Respir Crit Care Med 155:15–20PubMed
3.
go back to reference Wood GG, Martin E (1995) Withholding and withdrawing life-sustaining therapy in a Canadian intensive care unit. Can J Anaesth 42:186–191 Wood GG, Martin E (1995) Withholding and withdrawing life-sustaining therapy in a Canadian intensive care unit. Can J Anaesth 42:186–191
4.
go back to reference Faber-Langendoen K, Bartels DM (1992) Process of forgoing life-sustaining treatment in a university hospital: an empirical study. Crit Care Med 20:570–577 Faber-Langendoen K, Bartels DM (1992) Process of forgoing life-sustaining treatment in a university hospital: an empirical study. Crit Care Med 20:570–577
5.
go back to reference Pochard F, Azoulay E, Chevret S, Lemaire F, Hubert P, Canoui P, Grassin M, Zittoun R, Le Gall JR, Dhainaut JF, Schlemmer B, for the French FAMIREA group (2001) Symptoms of anxiety and depression in family members of intensive care unit patients: ethical hypothesis regarding decision-making capacity. Crit Care Med 29:1893–1897CrossRefPubMed Pochard F, Azoulay E, Chevret S, Lemaire F, Hubert P, Canoui P, Grassin M, Zittoun R, Le Gall JR, Dhainaut JF, Schlemmer B, for the French FAMIREA group (2001) Symptoms of anxiety and depression in family members of intensive care unit patients: ethical hypothesis regarding decision-making capacity. Crit Care Med 29:1893–1897CrossRefPubMed
6.
go back to reference Vincent JL (2001) Cultural differences in end-of-life care. Crit Care Med 29 [Suppl]:N52–N55 Vincent JL (2001) Cultural differences in end-of-life care. Crit Care Med 29 [Suppl]:N52–N55
7.
go back to reference Bone RC, Rackow EC, Weg JG (1990) Ethical and moral guidelines for the initiation, continuation, and withdrawal of intensive care. Chest 97:949–957 Bone RC, Rackow EC, Weg JG (1990) Ethical and moral guidelines for the initiation, continuation, and withdrawal of intensive care. Chest 97:949–957
8.
go back to reference Levy MM (2001) Evaluating our end-of-life practice. Crit Care 5:182–183 Levy MM (2001) Evaluating our end-of-life practice. Crit Care 5:182–183
9.
go back to reference Keenan SP, Busche KD, Chen LM, McCarthy L, Inman KJ, Sibbald WJ (1997) A retrospective review of a large cohort of patients undergoing the process of withholding or withdrawal of life sustaining. Crit Care Med 25:1324–1331 Keenan SP, Busche KD, Chen LM, McCarthy L, Inman KJ, Sibbald WJ (1997) A retrospective review of a large cohort of patients undergoing the process of withholding or withdrawal of life sustaining. Crit Care Med 25:1324–1331
10.
go back to reference Prendergast TJ, Claessens MT, Luce JM (1998) A national survey of end-of-life care for critically iII patients. Am J Respir Crit Care Med 158:1163–1167PubMed Prendergast TJ, Claessens MT, Luce JM (1998) A national survey of end-of-life care for critically iII patients. Am J Respir Crit Care Med 158:1163–1167PubMed
11.
go back to reference Treece PD, Engelberg RA, Crowley L, Chan JD, Rubenfeld GD, Steinberg KP, Curtis JR (2004) Evaluation of a standardized order form for the withdrawal of life sustaining treatment in the intensive care unit. Crit Care Med 32:1141–1148 Treece PD, Engelberg RA, Crowley L, Chan JD, Rubenfeld GD, Steinberg KP, Curtis JR (2004) Evaluation of a standardized order form for the withdrawal of life sustaining treatment in the intensive care unit. Crit Care Med 32:1141–1148
12.
go back to reference McLean RF, Tarshis J, Mazer D, Szalai JP (2000) Death in two Canadian intensive care units: institutional difference and changes over time. Crit Care Med 28:100–103 McLean RF, Tarshis J, Mazer D, Szalai JP (2000) Death in two Canadian intensive care units: institutional difference and changes over time. Crit Care Med 28:100–103
13.
go back to reference Chan JD, Treece PD, Engelberg RA, Crowley L, Rubenfeld GD, Steinberg KP, Curtis JR (2004) Narcotic and benzodiazepine use after withdrawal of life sustaining. Association with time to death? Chest 126:286–293 Chan JD, Treece PD, Engelberg RA, Crowley L, Rubenfeld GD, Steinberg KP, Curtis JR (2004) Narcotic and benzodiazepine use after withdrawal of life sustaining. Association with time to death? Chest 126:286–293
14.
go back to reference Hall RI, Rocker GM, Murray D (2004) Simple changes can improve conduct of end-of-life care in the intensive care unit. Can J Anaesth 51:631–636 Hall RI, Rocker GM, Murray D (2004) Simple changes can improve conduct of end-of-life care in the intensive care unit. Can J Anaesth 51:631–636
15.
go back to reference Giannini A, Pessina A, Tacchi EM (2003) End-of-life decisions in intensive care units: attitudes of physicians in an Italian urban setting. Intensive Care Med 29:1902–1910CrossRefPubMed Giannini A, Pessina A, Tacchi EM (2003) End-of-life decisions in intensive care units: attitudes of physicians in an Italian urban setting. Intensive Care Med 29:1902–1910CrossRefPubMed
16.
go back to reference Nolin T, Andersson R (2003) Withdrawal of medical treatment in the ICU. A cohort study of 318 cases during 1994–2000. Acta Anaesthesiol Scand 47:501–507 Nolin T, Andersson R (2003) Withdrawal of medical treatment in the ICU. A cohort study of 318 cases during 1994–2000. Acta Anaesthesiol Scand 47:501–507
17.
go back to reference Ferrand E, Robert R, Ingrand P, Lemaire F, for the French LATAREA group (2001) Withholding and withdrawal of life sustaining treatment in intensive-care units in France: a prospective survey. Lancet 357:9–14CrossRefPubMed Ferrand E, Robert R, Ingrand P, Lemaire F, for the French LATAREA group (2001) Withholding and withdrawal of life sustaining treatment in intensive-care units in France: a prospective survey. Lancet 357:9–14CrossRefPubMed
18.
go back to reference Vincent JL (1999) Forgoing life sustaining treatment in western European intensive care units: the results of an ethical questionnaire. Crit Care Med 27:1626–1633CrossRefPubMed Vincent JL (1999) Forgoing life sustaining treatment in western European intensive care units: the results of an ethical questionnaire. Crit Care Med 27:1626–1633CrossRefPubMed
19.
go back to reference Esteban A, Gordo F, Solsona JF, Alia I, Caballero J, Bouza C, Alcala-Zamora J, Cook DJ, Sanchez JM, Abizanda R, Miro G, Fernandez Del Cabo MJ, De Miguel E, Santos JA, Balerdi B (2001) Withdrawing and withholding life sustaining treatment in the intensive care unit: a Spanish prospective multi-centre observational study. Intensive Care Med 27:1744–1749 Esteban A, Gordo F, Solsona JF, Alia I, Caballero J, Bouza C, Alcala-Zamora J, Cook DJ, Sanchez JM, Abizanda R, Miro G, Fernandez Del Cabo MJ, De Miguel E, Santos JA, Balerdi B (2001) Withdrawing and withholding life sustaining treatment in the intensive care unit: a Spanish prospective multi-centre observational study. Intensive Care Med 27:1744–1749
20.
go back to reference Turner JS, Michell WL, Morgan CJ, Benatar SR (1996) Limitation of life sustaining: frequency and practice in a London and a Cape Town intensive care unit. Intensive Care Med 22:1020–1025 Turner JS, Michell WL, Morgan CJ, Benatar SR (1996) Limitation of life sustaining: frequency and practice in a London and a Cape Town intensive care unit. Intensive Care Med 22:1020–1025
21.
go back to reference Adib SM, Kawas SH, Hajjar TA (2003) End-of-life issues as perceived by Lebanese judges. Developing World Bioethics 3:10–26 Adib SM, Kawas SH, Hajjar TA (2003) End-of-life issues as perceived by Lebanese judges. Developing World Bioethics 3:10–26
22.
go back to reference Chang RW, Lee B, Jacobs S, Lee B (1989) Accuracy of decisions to withdraw therapy in critically ill patients: clinical judgment versus a computer model. Crit Care Med 17:1091–1997 Chang RW, Lee B, Jacobs S, Lee B (1989) Accuracy of decisions to withdraw therapy in critically ill patients: clinical judgment versus a computer model. Crit Care Med 17:1091–1997
23.
go back to reference Costa DE, Ghazal H, Al Khusaiby S (2002) Do not resuscitate orders and ethical decisions in a neonatal intensive care unit in a Muslim community. Arch Dis Child Fetal Neonatal Ed 86:F115–F119 Costa DE, Ghazal H, Al Khusaiby S (2002) Do not resuscitate orders and ethical decisions in a neonatal intensive care unit in a Muslim community. Arch Dis Child Fetal Neonatal Ed 86:F115–F119
24.
go back to reference Eidelman LA, Jakobson DJ, Pizov R, Geber D, Leibovitz L, Sprung CL (1998) Foregoing life-sustaining treatment in an Israeli ICU. Intensive Care Med 24:162–166 Eidelman LA, Jakobson DJ, Pizov R, Geber D, Leibovitz L, Sprung CL (1998) Foregoing life-sustaining treatment in an Israeli ICU. Intensive Care Med 24:162–166
25.
go back to reference Iyilikçi L, Erbayraktar S, Gökmen N, Ellidokuz H, Kara HC, Günerli A (2004) Practices of anaesthesiologists with regard to withholding and withdrawal of life sustaining treatment from the critically ill in Turkey. Acta Anaesthesiol Scand 48:457–462 Iyilikçi L, Erbayraktar S, Gökmen N, Ellidokuz H, Kara HC, Günerli A (2004) Practices of anaesthesiologists with regard to withholding and withdrawal of life sustaining treatment from the critically ill in Turkey. Acta Anaesthesiol Scand 48:457–462
26.
go back to reference Maksoud L, Jahnigen DW, Skibinski CI (1993) Not resuscitate orders and the cost of Death. Arch Intern Med 153:1249–1253 Maksoud L, Jahnigen DW, Skibinski CI (1993) Not resuscitate orders and the cost of Death. Arch Intern Med 153:1249–1253
27.
go back to reference Lofmark R, Nilstun T (1997) Deciding not to resuscitate. Responsibilities of physicians and nurses: a proposal. Scand J Caring Sci 11:207–211 Lofmark R, Nilstun T (1997) Deciding not to resuscitate. Responsibilities of physicians and nurses: a proposal. Scand J Caring Sci 11:207–211
28.
go back to reference Support Principal Investigators (1995) A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (Support). JAMA 274:1591–1598 Support Principal Investigators (1995) A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (Support). JAMA 274:1591–1598
29.
go back to reference Sonnenblick M, Gratch L, Raveh D, Steinberg A, Yinnon AM (2003) Epidemiology of decision on life-sustaining treatment in the general internal medicine division. Harefuah 142:650–653 Sonnenblick M, Gratch L, Raveh D, Steinberg A, Yinnon AM (2003) Epidemiology of decision on life-sustaining treatment in the general internal medicine division. Harefuah 142:650–653
30.
go back to reference Way J, Back AL, Curtis JR (2002) Withdrawing life sustaining treatment and resolution of conflict with families. BMJ 325:1342–1345 Way J, Back AL, Curtis JR (2002) Withdrawing life sustaining treatment and resolution of conflict with families. BMJ 325:1342–1345
31.
go back to reference Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM, Reinhart K, Thompson BT (2004) Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med 30:770–84 Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM, Reinhart K, Thompson BT (2004) Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med 30:770–84
Metadata
Title
Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study
Publication date
01-04-2005
Published in
Intensive Care Medicine / Issue 4/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-005-2578-4

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