Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 12/2007

01-12-2007 | Brief Report

Imipramine reverses the depressive symptoms in sepsis survivor rats

Authors: Lisiane Tuon, Clarissa M. Comim, Moises M. Antunes, Larissa S. Constantino, Roberta A. Machado, Ivan Izquierdo, João Quevedo, Felipe Dal-Pizzol

Published in: Intensive Care Medicine | Issue 12/2007

Login to get access

Abstract

Objective

To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats.

Design and setting

Prospective, controlled experiment in an animal basic science laboratory.

Subjects

Male Wistar rats weighing 300–350 g.

Interventions

The rats underwent cecal ligation and perforation (CLP; sepsis group) with “basic support” (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test.

Measurements and results

The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine.

Conclusions

The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.
Literature
1.
Granja C, Dias C, Costa-Pereira A, Sarmento A (2004) Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness. Crit Care Med 8:R91–R98CrossRef
2.
Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JC, Dal-Pizzol F (2004) Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 32:342–349PubMedCrossRef
3.
Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J, Dal-Pizzol F (2005) Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit Care Med 33:221–223PubMedCrossRef
4.
Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 29:1782–1789PubMedCrossRef
5.
Barichello T, Martins MR, Reinke A, Constantino LS, Machado RA, Reus GZ, Valvassori SS, Moreira JC, Quevedo J, Dal-Pizzol F (2007) Behavioural deficits in CLP-induced sepsis survivor rats. Braz J Med Biol Res 40:831–837PubMedCrossRef
6.
Porsolt RD (1979) Animal model of depression. Biomedicine 30:139–140PubMed
7.
Viana A, Rego J-C, Poser GV, Ferraz A, Heckler AP, Costentin J, Kuze Rates SM (2005) The antidepressive-like effect of hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. Neuropharmacology 49:1042–1052PubMedCrossRef
8.
Vianna MR, Alonso M, Viola H, Quevedo J, de Paris F, Furman M, de Stein ML, Medina JH, Izquierdo I (2000) Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat. Learn Mem 7:333–340PubMedCrossRef
9.
Cryan JF, Valentino RJ, Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29:547–569PubMedCrossRef
10.
Gardier AM, Bourin M (2001) Appropriate use of ‘knockout’ mice as models of depression or models of testing the efficacy of antidepressants. Psychopharmacology (Berl) 153:393–394CrossRef
Metadata
Title
Imipramine reverses the depressive symptoms in sepsis survivor rats
Authors
Lisiane Tuon
Clarissa M. Comim
Moises M. Antunes
Larissa S. Constantino
Roberta A. Machado
Ivan Izquierdo
João Quevedo
Felipe Dal-Pizzol
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 12/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0804-y

Other articles of this Issue 12/2007

Intensive Care Medicine 12/2007 Go to the issue

Correspondence

Chest physiotherapy and outcomes in ICU

Original

Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue

Correspondence

Physiotherapy in critical care

Brief Report

Lack of agreement between thermodilution and electrical velocimetry cardiac output measurements

Correspondence

Reply to the comment by Dr. Bernstein

Original

Activated protein C improves survival in severe sepsis patients with elevated troponin